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1.发明公开DERIVES DE BENZO (E) (1,4) OXAZINO (3,2-G) ISOINDOLE SUBSTI TUES, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT 有权苯并（E）（1.4）恶嗪（3.2克）异吲哚衍生物，用于生产和含有这些药物组合物
公开(公告)号：EP1556387A1
公开(公告)日：2005-07-27
申请号：EP03809362.1
申请日：2003-10-17
发明人： COUDERT, Gérard , LEPIFRE, Franck , CAIGNARD, Daniel-Henri , RENARD, Pierre , HICKMAN, John , PIERRE, Alain , KRAUS-BERTHIER, Laurence
IPC分类号： C07D498/04 , A61K31/535 , C07D498/14 , C07D265/38
CPC分类号： C07D497/04 , C07D497/14
摘要： The invention concerns compounds of formula (I), wherein: W1 represents with the carbon atoms whereto it is bound, a phenyl group or a pyridinyl group; Z represents a group selected among a hydrogen atom, halogen, a linear or branched C1-C6 alkyl, aryl, linear or branched C1-C6 arylalkyl, aryloxy, linear or branched C1-C6 arylalkoxy, hydroxy, linear or branched C1-C6 alkoxy group; R1 is such as defined in the description; R2 represents a hydrogen atom or a group of formula -CH2CH2O-R8; R3, R4 represent each a hydrogen atom, a linear or branched C1-C6 alkyl, aryl, linear or branched C1-C6 aryalkyl group; n represents an integer between 1 and 6 inclusive. The invention is useful for preparing medicines.
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2.发明授权DERIVES DE 9-AMINO-PODOPHYLLOTOXINE, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT 有权DER 9-AMINO-PODOPHYLLOXOXINE，LEUR PROCEDE DE PREPARATION ET LES组合物药物组合物QUI LES CONTIENNENT
公开(公告)号：EP1664055B1
公开(公告)日：2006-12-13
申请号：EP04787274.2
申请日：2004-09-01
发明人： MONNERET, Claude , DAUZONNE, Daniel , HICKMAN, John , PIERRE, Alain , KRAUS-BERTHIER, Laurence , PFEIFFER, Bruno , RENARD, Pierre
IPC分类号： C07D493/04 , A61K31/36 , A61P35/00
CPC分类号： C07D493/04
摘要： The invention relates to compounds of formula (I), wherein R1 is a group selected from hydrogen, alkyl, aryl, aryalkil, heteroaryl, heteroarylalkyl, alkylcarbonyl, arylcarbonyl, arylalkylcarbonyl, alkoxycarbonyl, aryloxycarbonyl, arylalkoxycarbonyl, heterocycloalkoxycarbonyl, alkylsulfonyl, arylsulfonyl, arylalkylsulfonyl, phosphonic and Si(Ra)2Rb, Y is a group selected from HN-NH and N-R2, R3 is a hydrogen atom, an alkyl, cycloalkyl, aryl, arylalkyl group, R4 is hydrogen atom or an alkyl group, enantiomers, diastereoisomers and the salts thereof.
摘要翻译： 烷基，芳基，芳基烷基，杂芳基，杂芳基烷基，烷基羰基，芳基羰基，芳基烷基羰基，烷氧基羰基，芳氧基羰基，芳基烷氧基羰基，杂环烷氧基羰基，烷基磺酰基，芳基磺酰基，芳基烷基磺酰基， 膦酸和Si（Ra）2Rb，Y是选自HN-NH和NR 2的基团，R 3是氢原子，烷基，环烷基，芳基，芳基烷基，R 4是氢原子或烷基，对映异构体，非对映异构体 及其盐。
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3.发明公开NOUVEAUX DERIVES TRICYCLIQUES DE DIHYDRO-QUINOLEINES, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT 审中-公开新DIHYDROISOCHINOLINTRIZYKLISCHE衍生物，其制造方法和药物制剂
公开(公告)号：EP1389210A1
公开(公告)日：2004-02-18
申请号：EP02740805.3
申请日：2002-05-22
发明人： HUSSON, Henri-Philippe , GIORGI-RENAULT, Sylviane , DESBENE, Stéphanie , HICKMAN, John , PIERRE, Alain , KRAUS-BERTHIER, Laurence , PFEIFFER, Bruno , RENARD, Pierre
IPC分类号： C07D491/14 , C07D497/14 , C07D491/04
CPC分类号： C07D491/04 , C07D491/14 , C07D497/14
摘要： The invention concerns a compound of formula (I), wherein (a) represents a single or double bond; (b) represents a cycle selected among (i), (ii), (iii), (iv), (v), (vi) and (vii). The inventive compounds, besides their novelty, exhibit very interesting antitumour properties.
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4.发明授权DERIVES DE BENZO (E) (1,4) OXAZINO (3,2-G) ISOINDOLE SUBSTI TUES, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT 有权苯并（E）（1.4）恶嗪（3.2克）异吲哚衍生物，用于生产和含有这些药物组合物
公开(公告)号：EP1556387B1
公开(公告)日：2007-04-04
申请号：EP03809362.1
申请日：2003-10-17
发明人： COUDERT, Gérard , LEPIFRE, Franck , CAIGNARD, Daniel-Henri , RENARD, Pierre , HICKMAN, John , PIERRE, Alain , KRAUS-BERTHIER, Laurence
IPC分类号： C07D498/04 , A61K31/535 , C07D498/14 , C07D265/38
CPC分类号： C07D497/04 , C07D497/14
摘要： The invention concerns compounds of formula (I), wherein: W1 represents with the carbon atoms whereto it is bound, a phenyl group or a pyridinyl group; Z represents a group selected among a hydrogen atom, halogen, a linear or branched C1-C6 alkyl, aryl, linear or branched C1-C6 arylalkyl, aryloxy, linear or branched C1-C6 arylalkoxy, hydroxy, linear or branched C1-C6 alkoxy group; R1 is such as defined in the description; R2 represents a hydrogen atom or a group of formula -CH2CH2O-R8; R3, R4 represent each a hydrogen atom, a linear or branched C1-C6 alkyl, aryl, linear or branched C1-C6 aryalkyl group; n represents an integer between 1 and 6 inclusive. The invention is useful for preparing medicines.
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5.发明公开DERIVES TRICYCLIQUES DE DIHYDROQUINOLEINES,LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT 审中-公开三环二氢喹啉，PROCESS FOR THEIR和药物组合物含有它们的
公开(公告)号：EP1399455A2
公开(公告)日：2004-03-24
申请号：EP02735551.0
申请日：2002-05-22
发明人： HUSSON, Henri-Philippe , GIORGI-RENAULT, Sylviane , DESBENE, Stéphanie , HICKMAN, John , PIERRE, Alain , KRAUS-BERTHIER, Laurence , PFEIFFER, Bruno , RENARD, Pierre
IPC分类号： C07F9/6561 , C07D491/14 , C07D491/04
CPC分类号： C07D491/04 , C07D491/14 , C07F9/6561
摘要： The invention concerns a compound of formula (I), wherein: (a) represents a single or double bond; (b) represents a cycle selected among (i), (ii), (iii), (iv) and (v); R9a, R9b, R9c, X and Y are such as defined in the description; R1 represents a group selected among hydrogen, aryl, heteroaryl, cycloalkyl, alkyl optionally substituted, and COR11, wherein R11 is such as defined in the description; R2 to R8 represent each a group selected among hydrogen, halogen, hydroxy, polyhalogenoalkyl, nitro, alkyl optionally substituted, amino optionally substituted, alkoxy optionally substituted, -OPO(OH)2 and (II), wherein m represents an integer such that 1 ≤ m ≤ 4, or R2 with R3, or R3 with R4, or R4 with R5 together form with the carbon atoms which bear them a monocyclic or bicyclic group optionally containing 1 or 2 heteroatoms and optionally substituted; R16 represents a hydrogen atom or an alkyl group; (c) represents an aryl, heteroaryl or arylalkyl group; as well as its optical isomers, its addition salts to a pharmaceutically acceptable acid or base as well as its hydrates and solvates. The invention is useful for preparing medicines.
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6.发明授权DERIVES DE 9-AMINO-PODOPHYLLOTOXINE, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT 有权9 AMINOPODOPHYLLOTOXINDERIVATE，其制备方法和药物组合物含有这些衍生物
公开(公告)号：EP1664055B9
公开(公告)日：2007-10-10
申请号：EP04787274.2
申请日：2004-09-01
发明人： MONNERET, Claude , DAUZONNE, Daniel , HICKMAN, John , PIERRE, Alain , KRAUS-BERTHIER, Laurence , PFEIFFER, Bruno , RENARD, Pierre
IPC分类号： C07D493/04 , A61K31/36 , A61P35/00
CPC分类号： C07D493/04
摘要： The invention relates to compounds of formula (I), wherein R1 is a group selected from hydrogen, alkyl, aryl, aryalkil, heteroaryl, heteroarylalkyl, alkylcarbonyl, arylcarbonyl, arylalkylcarbonyl, alkoxycarbonyl, aryloxycarbonyl, arylalkoxycarbonyl, heterocycloalkoxycarbonyl, alkylsulfonyl, arylsulfonyl, arylalkylsulfonyl, phosphonic and Si(Ra)2Rb, Y is a group selected from HN-NH and N-R2, R3 is a hydrogen atom, an alkyl, cycloalkyl, aryl, arylalkyl group, R4 is hydrogen atom or an alkyl group, enantiomers, diastereoisomers and the salts thereof.
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7.发明公开DERIVES DE 9-AMINO-PODOPHYLLOTOXINE, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT 有权9 AMINOPODOPHYLLOTOXINDERIVATE，其制备方法和药物组合物含有这些衍生物
公开(公告)号：EP1664055A1
公开(公告)日：2006-06-07
申请号：EP04787274.2
申请日：2004-09-01
发明人： MONNERET, Claude , DAUZONNE, Daniel , HICKMAN, John , PIERRE, Alain , KRAUS-BERTHIER, Laurence , PFEIFFER, Bruno , RENARD, Pierre
IPC分类号： C07D493/04 , A61K31/36 , A61P35/00
CPC分类号： C07D493/04
摘要： The invention relates to compounds of formula (I), wherein R1 is a group selected from hydrogen, alkyl, aryl, aryalkil, heteroaryl, heteroarylalkyl, alkylcarbonyl, arylcarbonyl, arylalkylcarbonyl, alkoxycarbonyl, aryloxycarbonyl, arylalkoxycarbonyl, heterocycloalkoxycarbonyl, alkylsulfonyl, arylsulfonyl, arylalkylsulfonyl, phosphonic and Si(Ra)2Rb, Y is a group selected from HN-NH and N-R2, R3 is a hydrogen atom, an alkyl, cycloalkyl, aryl, arylalkyl group, R4 is hydrogen atom or an alkyl group, enantiomers, diastereoisomers and the salts thereof.
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