公开(公告)号：EP1250091A4

公开(公告)日：2003-05-07

申请号：EP01904882

申请日：2001-01-17

申请人： MALLINCKRODT INC

发明人： ACHILEFU SAMUEL I ,  RAJAGOPALAN RAGHAVAN ,  DORSHOW RICHARD B ,  BUGAJ JOSEPH E

IPC分类号： A61B1/00 ,  A61K49/00 ,  A61K51/00 ,  C09B23/00 ,  A61B10/00 ,  A61B8/00

CPC分类号： A61K49/0056 ,  A61K49/0032

公开(公告)号：EP1326649A4

公开(公告)日：2007-03-21

申请号：EP01981461

申请日：2001-10-05

申请人： MALLINCKRODT INC

发明人： ACHILEFU SAMUEL ,  RAJAGOPALAN RAGHAVAN ,  DORSHOW RICHARD B ,  BUGAJ JOSEPH E

IPC分类号： G01N21/64 ,  A61K49/00 ,  A61P9/00 ,  A61P13/12 ,  C07D209/08 ,  C07D209/12 ,  C07D209/60 ,  C07D405/14 ,  C07H15/26 ,  G01N21/27 ,  G01N21/35

CPC分类号： A61K49/0021 ,  A61K49/0032

公开(公告)号：EP1390080A4

公开(公告)日：2006-09-13

申请号：EP02769275

申请日：2002-04-18

申请人： MALLINCKRODT INC

发明人： RAJAGOPALAN RAGHAVAN ,  CANTRELL GARY L ,  BUGAJ JOSEPH E ,  ACHILEFU SAMUEL I ,  DORSHOW RICHARD B

IPC分类号： A61K51/00 ,  C07D491/06 ,  A61K31/5025 ,  A61K31/7042 ,  A61K31/7088 ,  A61K38/00 ,  A61K38/22 ,  A61K39/395 ,  A61K41/00 ,  A61K47/48 ,  A61K49/00 ,  A61M36/14 ,  A61N5/06 ,  A61P9/00 ,  A61P9/10 ,  A61P13/08 ,  A61P15/14 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07D471/06 ,  C07D498/06

CPC分类号： A61K49/0026 ,  A61K41/0057 ,  A61K47/64 ,  A61K49/0039 ,  A61K49/0041 ,  A61K49/0056 ,  C07D471/06

公开(公告)号：EP1326651A4

公开(公告)日：2006-01-18

申请号：EP01987741

申请日：2001-10-05

申请人： MALLINCKRODT INC

发明人： ACHILEFU SAMUEL ,  RAJAGOPALAN RAGHAVAN ,  DORSHOW RICHARD B ,  BUGAJ JOSEPH E ,  JIMENEZ HERMO N

IPC分类号： C07H15/26 ,  A61K49/00 ,  C07D209/08 ,  C07D209/12 ,  C07D209/60 ,  C07D405/14 ,  A61K51/00

CPC分类号： C07D405/14 ,  C07D209/08 ,  C07D209/12 ,  C07D209/60

公开(公告)号：EP1326647A4

公开(公告)日：2005-05-18

申请号：EP01979683

申请日：2001-10-05

申请人： MALLINCKRODT INC

发明人： ACHILEFU SAMUEL ,  RAJAGOPALAN RAGHAVAN ,  DORSHOW RICHARD B ,  BUGAJ JOSEPH E ,  JIMENEZ HERMO N

IPC分类号： A61K49/00 ,  C09B23/02

CPC分类号： A61K49/0032 ,  C09B23/02

摘要： Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible regionof light are disclosed. These compounds are useful for physiological and organ function monitoring. Particularly, the molecules of the invention are useful for optical diagnosis of renal and cardiac diseases and for estimation of blood volume in vivo.

公开(公告)号：EP1263477A4

公开(公告)日：2003-06-18

申请号：EP01918287

申请日：2001-03-01

申请人： MALLINCKRODT INC

发明人： COMBS ARTHUR H ,  DORSHOW RICHARD B ,  BUGAJ JOSEPH E ,  RAJAGOPALAN RAGHAVAN ,  ACHILEFU SAMUEL I

IPC分类号： A61B5/00 ,  A61B5/0275 ,  A61K49/00 ,  A61K51/00 ,  G01N33/00

CPC分类号： A61B5/14546 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/0275 ,  A61B5/412 ,  A61K49/0002 ,  A61K49/0017 ,  A61K49/0034 ,  A61K49/0043 ,  A61K49/0056 ,  A61K51/0474

摘要： A method of measuring physiological function of a group of body cells, includes the step of selecting a detectable agent capable of absorbing or emitting a measurable electromagnetic emission. The agent is introduced into body fluid which contacts the group of body cells. The absorbance or emission is measured, and physiological function is determined based on measurement of the absorbance or emission. Measurements may be made noninvasively or with the use of a modified pulmonary artery catheter. Multiple agents which can be distinguished from each other can be utilized simultaneously to measure physiological functions at the same time.

公开(公告)号：EP1250333A4

公开(公告)日：2003-05-28

申请号：EP01942624

申请日：2001-01-17

申请人： MALLINCKRODT INC

发明人： ACHILEFU SAMUEL I ,  RAJAGOPALAN RAGHAVAN ,  DORSHOW RICHARD B ,  BUGAJ JOSEPH E

IPC分类号： C07H15/26 ,  A61K41/00 ,  A61K49/00 ,  A61K49/04 ,  C07D209/12 ,  C07D209/60 ,  C07D405/12 ,  C07K7/06 ,  C09B23/00 ,  C09B23/01 ,  C09B23/08 ,  C07D403/08

CPC分类号： A61K49/0032 ,  A61K41/0033 ,  A61K41/0057 ,  A61K49/0056 ,  C09B23/0066 ,  C09B23/08

公开(公告)号：EP0946203A4

公开(公告)日：2000-03-29

申请号：EP97924639

申请日：1997-05-09

申请人： MALLINCKRODT INC

发明人： FUNG ELLA Y ,  RAJAGOPALAN RAGHAVAN

IPC分类号： C07D277/64 ,  A61K49/00 ,  C07D235/06 ,  C07D293/10 ,  C07D293/12 ,  C07D417/14 ,  G01N31/00 ,  G01N33/48

CPC分类号： A61K49/0021

摘要： This invention provides functional dyes of general formula (1) wherein R?1, R2, and R5¿ may be the same or different and are selected from the group consisting of hydrogen, C¿1?-C10 alkyl, C1-C10 alkoxyl, hydroxyl, C1-C10 hydroxyalkyl, C1-C10 alkoxyalkyl, C1-C10 aryl, carboxyl, C1-C10 carboxylalkyl, halogen, nitro, C1-C10 alkoxycarbonyl, mercapto, C1-C10 mercaptoalkyl, C1-C10 alkylthio, sulfonate, and -(CH2)m-N(R?6)(R7¿) wherein R?6 and R7¿ are independently hydrogen or C¿1?-C10 alkyl, C1-C10 acyl, and R?6 and R7¿ are capable of forming 5, 6, or 7 membered rings which may optionally be substituted with -O-, -NR8, or -S-; R?3 and R4¿ may be the same or different and are selected from the group consisting of C¿1?-C10 alkyl, C1-C10 hydroxyalkyl, C1-C10 alkoxyalkyl, C1-C10 aryl, C1-C10 carboxylalkyl, C1-C10 alkyl sulfonate, mercapto alkyl and -(CH2)mN(R?6)(R7); W1 and W2¿ may be the same or different and are selected from the group consisting of -S-, -O-, -Se-, -Te-, -NR8 and C(R9)(R10); and m is about 0-10; R8 is hydrogen, C¿1?-C10 alkyl, C1-C10 alkoxy, C1-C10 mercaptoalkyl, hydroxyl, C1-C10 hydroxyalkyl, C1-C10 alkoxyalkyl, C1-C10 aryl, C1-C10 carboxylalkyl, C1-C10 alkoxycarbonyl, C1-C10 alkylthio, and -(CH2)m-N(R?6)(R7); R9 and R10¿ are independently hydrogen, C¿1?-C10 alkyl, C1-C10 alkoxyl, C1-C10 hydroxyalkyl, C1-C10 alkoxyalkyl, C1-C10 carboxyalkyl, C1-C10 alkoxycarbonyl, and -(CH2)m-N(R?6)(R7¿); and A is selected from the group consisting of -(CH¿2?)m, -C(R?9)(R10¿), -(CH¿2?)m-N(R?6)(R7¿), -O-, -S-, or -NR8.