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    A process for preparing N-glycolylneuraminic acid derivatives
    21.
    发明公开
    A process for preparing N-glycolylneuraminic acid derivatives 失效
    一种制备N-羟乙酰神经氨酸衍生物的方法

    公开(公告)号：EP0219070A2

    公开(公告)日：1987-04-22

    申请号：EP86114034.1

    申请日：1986-10-10

    申请人： MECT CORPORATION

    发明人： Shibayama, Shohei ,  Yoshimura, Shoji ,  Ito, Masayoshi ,  Shitori, Yoshiyasu ,  Ogawa, Tomoya

    IPC分类号： C07H15/04 ,  C07B59/00

    CPC分类号： C07H15/04

    摘要： This invention provides a novel process for preparing a compound represented by the formula
    In accordance with this invention, the compound is prepared by reacting a compound represented by the formula
    with glycolic acid in the presence of dicyclohexylcarbodiimide. The compound (2) is a useful precursor for the preparation of N-glycolylneuraminic acid:

    摘要翻译： 本发明提供了一种制备下式所示化合物的新方法。根据本发明，所述化合物通过在二环己基碳化二亚胺存在下使由下式表示的化合物与乙醇酸反应来制备。 化合物（2）是用于制备N-羟乙酰神经氨酸的有用前体：

    Use of N-methyl-sphingosine as inhibitor of cell growth
    29.
    发明公开
    Use of N-methyl-sphingosine as inhibitor of cell growth 失效
    Verwendung von Sphingosin und N-Methyl-Sphingosin als Zell-Wachstums-Inhibitor。

    公开(公告)号：EP0381514A2

    公开(公告)日：1990-08-08

    申请号：EP90301099.9

    申请日：1990-02-02

    申请人： The Biomembrane Institute ,  CORNELL RESEARCH FOUNDATION, INC. ,  MECT CORPORATION

    发明人： Igarashi, Yasuyuki ,  Toyokuni, Tatsushi ,  Hakomori, Sen-itiroh ,  Racker, Efraim, Department of Biochemistry ,  Fujita, Shuji ,  Sugimoto, Mamoru ,  Ito, Masayoshi ,  Shitori, Yoshiyasu ,  Ogawa, Tomoya

    IPC分类号： A61K31/13

    CPC分类号： A61K31/13

    摘要： A medicament for inhibiting growth of human and animal cells comprising: (1) a cell growth inhibitory amount of a one or more growth inhibitors comprising synthetically prepared sphingosine, synthetically prepared N-methyl-sphingosine or pharmaceutically acceptable salts thereof; and (2) a pharmaceutically acceptable carrier, diluent or excipient. A method for inhibiting growth of human and animal cells in vivo comprising contacting said cells with a cell growth inhibitory amount of one or more growth inhibitors comprising synthetically prepared sphingosine, synthetically prepared N-methyl-sphingosine or pharmaceutically acceptable salts thereof. A medicament for inhibiting growth of human and animal cells comprising: (1) A cell growth inhibitory amount of one or more growth inhibitors comprising sphingosine prepared from naturally occurring sphingolipid, N-methyl-sphingosine prepared from naturally occurring sphingolipid or pharmaceutically acceptable salts thereof; and (2) a pharmaceutically acceptable carrier, diluent or excipient. A method of inhibiting growth of human and animal cells in vivo comprising contacting said cells with a cell growth inhibitory amount of one or more growth inhibitors comprising sphingosine prepared from naturally occurring sphingolipid, N-methyl-sphingosine prepared from naturally occurring sphingolipid or pharmaceutically acceptable salts thereof.

    摘要翻译： 一种用于抑制人和动物细胞生长的药物，包括：（1）细胞生长抑制量的一种或多种生长抑制剂，其包含合成制备的鞘氨醇，合成制备的N-甲基 - 鞘氨醇或其药学上可接受的盐; 和（2）药学上可接受的载体，稀释剂或赋形剂。 一种用于抑制体内人和动物细胞生长的方法，包括使所述细胞与细胞生长抑制量的一种或多种生长抑制剂接触，所述生长抑制剂包括合成制备的鞘氨醇，合成制备的N-甲基 - 鞘氨醇或其药学上可接受的盐。 一种用于抑制人和动物细胞生长的药物，包括：（1）细胞生长抑制量的一种或多种生长抑制剂，其包含由天然存在的鞘脂制备的鞘氨醇，由天然存在的鞘脂制备的N-甲基 - 鞘氨醇或其药学上可接受的盐; 和（2）药学上可接受的载体，稀释剂或赋形剂。 一种在体内抑制人和动物细胞生长的方法，其包括使所述细胞与细胞生长抑制量的一种或多种生长抑制剂接触，所述生长抑制剂包含由天然存在的鞘脂制备的鞘氨醇，由天然存在的鞘脂制备的N-甲基 - 鞘氨醇或药学上可接受的盐 它们。