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    Use of N-methyl-sphingosine as inhibitor of cell growth
    2.
    发明公开
    Use of N-methyl-sphingosine as inhibitor of cell growth 失效
    Verwendung von Sphingosin und N-Methyl-Sphingosin als Zell-Wachstums-Inhibitor。

    公开(公告)号：EP0381514A2

    公开(公告)日：1990-08-08

    申请号：EP90301099.9

    申请日：1990-02-02

    申请人： The Biomembrane Institute ,  CORNELL RESEARCH FOUNDATION, INC. ,  MECT CORPORATION

    发明人： Igarashi, Yasuyuki ,  Toyokuni, Tatsushi ,  Hakomori, Sen-itiroh ,  Racker, Efraim, Department of Biochemistry ,  Fujita, Shuji ,  Sugimoto, Mamoru ,  Ito, Masayoshi ,  Shitori, Yoshiyasu ,  Ogawa, Tomoya

    IPC分类号： A61K31/13

    CPC分类号： A61K31/13

    摘要： A medicament for inhibiting growth of human and animal cells comprising: (1) a cell growth inhibitory amount of a one or more growth inhibitors comprising synthetically prepared sphingosine, synthetically prepared N-methyl-sphingosine or pharmaceutically acceptable salts thereof; and (2) a pharmaceutically acceptable carrier, diluent or excipient. A method for inhibiting growth of human and animal cells in vivo comprising contacting said cells with a cell growth inhibitory amount of one or more growth inhibitors comprising synthetically prepared sphingosine, synthetically prepared N-methyl-sphingosine or pharmaceutically acceptable salts thereof. A medicament for inhibiting growth of human and animal cells comprising: (1) A cell growth inhibitory amount of one or more growth inhibitors comprising sphingosine prepared from naturally occurring sphingolipid, N-methyl-sphingosine prepared from naturally occurring sphingolipid or pharmaceutically acceptable salts thereof; and (2) a pharmaceutically acceptable carrier, diluent or excipient. A method of inhibiting growth of human and animal cells in vivo comprising contacting said cells with a cell growth inhibitory amount of one or more growth inhibitors comprising sphingosine prepared from naturally occurring sphingolipid, N-methyl-sphingosine prepared from naturally occurring sphingolipid or pharmaceutically acceptable salts thereof.

    摘要翻译： 一种用于抑制人和动物细胞生长的药物，包括：（1）细胞生长抑制量的一种或多种生长抑制剂，其包含合成制备的鞘氨醇，合成制备的N-甲基 - 鞘氨醇或其药学上可接受的盐; 和（2）药学上可接受的载体，稀释剂或赋形剂。 一种用于抑制体内人和动物细胞生长的方法，包括使所述细胞与细胞生长抑制量的一种或多种生长抑制剂接触，所述生长抑制剂包括合成制备的鞘氨醇，合成制备的N-甲基 - 鞘氨醇或其药学上可接受的盐。 一种用于抑制人和动物细胞生长的药物，包括：（1）细胞生长抑制量的一种或多种生长抑制剂，其包含由天然存在的鞘脂制备的鞘氨醇，由天然存在的鞘脂制备的N-甲基 - 鞘氨醇或其药学上可接受的盐; 和（2）药学上可接受的载体，稀释剂或赋形剂。 一种在体内抑制人和动物细胞生长的方法，其包括使所述细胞与细胞生长抑制量的一种或多种生长抑制剂接触，所述生长抑制剂包含由天然存在的鞘脂制备的鞘氨醇，由天然存在的鞘脂制备的N-甲基 - 鞘氨醇或药学上可接受的盐 它们。

    Use of N-methyl-sphingosine as inhibitor of cell growth
    3.
    发明公开
    Use of N-methyl-sphingosine as inhibitor of cell growth 失效
    作为细胞生长抑制剂的丝氨酸和N-甲基 - 丝胶蛋白

    公开(公告)号：EP0381514A3

    公开(公告)日：1991-07-17

    申请号：EP90301099.9

    申请日：1990-02-02

    申请人： The Biomembrane Institute ,  CORNELL RESEARCH FOUNDATION, INC. ,  MECT CORPORATION

    发明人： Igarashi, Yasuyuki ,  Toyokuni, Tatsushi ,  Hakomori, Sen-itiroh ,  Racker, Efraim, Department of Biochemistry ,  Fujita, Shuji ,  Sugimoto, Mamoru ,  Ito, Masayoshi ,  Shitori, Yoshiyasu ,  Ogawa, Tomoya

    IPC分类号： A61K31/13

    CPC分类号： A61K31/13

    摘要： A medicament for inhibiting growth of human and animal cells comprising: (1) a cell growth inhibitory amount of a one or more growth inhibitors comprising synthetically prepared sphingosine, synthetically prepared N-methyl-sphingosine or pharmaceutically acceptable salts thereof; and (2) a pharmaceutically acceptable carrier, diluent or excipient. A method for inhibiting growth of human and animal cells in vivo comprising contacting said cells with a cell growth inhibitory amount of one or more growth inhibitors comprising synthetically prepared sphingosine, synthetically prepared N-methyl-sphingosine or pharmaceutically acceptable salts thereof. A medicament for inhibiting growth of human and animal cells comprising: (1) A cell growth inhibitory amount of one or more growth inhibitors comprising sphingosine prepared from naturally occurring sphingolipid, N-methyl-sphingosine prepared from naturally occurring sphingolipid or pharmaceutically acceptable salts thereof; and (2) a pharmaceutically acceptable carrier, diluent or excipient. A method of inhibiting growth of human and animal cells in vivo comprising contacting said cells with a cell growth inhibitory amount of one or more growth inhibitors comprising sphingosine prepared from naturally occurring sphingolipid, N-methyl-sphingosine prepared from naturally occurring sphingolipid or pharmaceutically acceptable salts thereof.

    Novel sphingenine and derivatives thereof
    6.
    发明公开
    Novel sphingenine and derivatives thereof 失效
    鞘氨醇和衍生物davon。

    公开(公告)号：EP0372571A2

    公开(公告)日：1990-06-13

    申请号：EP89122689.6

    申请日：1989-12-08

    申请人： MECT CORPORATION

    发明人： Fujita, Shuji ,  Sugimoto, Mamoru ,  Ito, Masayoshi ,  Ogawa, Tomoya

    IPC分类号： C07C69/18 ,  C07C43/15 ,  C07C309/66 ,  C07C247/08 ,  C07C233/18 ,  C07C217/46 ,  C07H15/10

    CPC分类号： C07C43/178 ,  C07C69/145 ,  C07C217/46 ,  C07C233/18 ,  C07C247/08

    摘要： A sphingenine and derivatives thereof herein provided are represented by the following general formulas (I) and (II):

    in the formulas (I) and (II), R 1 represents a hydrogen atom, an acetyl group or a methanesulfonyl group; R 2 represents a hydrogen atom or an ethoxyethyl group; R 3 represents an azido group, an amino group, an alkylamido group, an arylamido group, an aralkylamido group or a tetracosanamido group; R 4 represents a hydrogen atom or an ethoxyethyl group; EE represents an ethoxy ethyl group; and n is an integer ranging from 1 to 22. These sphingenine and derivatives thereof are very useful as intermediates for synthesizing glycolipids and gangliosides which are effective as markers of tumours, in particular, in the preparation of ceramide parts of the glycolipids and gangliosides.

    摘要翻译： 本文提供的鞘氨醇及其衍生物由式（I）和（II）中的以下通式（I）和（II）表示：，式（I）和（II）中的R 1表示氢原子，乙酰基或 甲磺酰基; R 2表示氢原子或乙氧基乙基; R 3表示叠氮基，氨基，烷基酰氨基，芳基酰氨基，芳烷基酰氨基或四聚山酰胺基; R 4表示氢原子或乙氧基乙基; EE表示乙氧基乙基; n是1至22范围内的整数。这些鞘氨醇及其衍生物作为合成作为肿瘤标记有效的糖脂和神经节苷脂的中间体非常有用，特别是制备糖脂和神经节苷脂的神经酰胺部分。

    Novel sphingenine and derivatives thereof
    8.
    发明公开
    Novel sphingenine and derivatives thereof 失效
    新型配体及其衍生物

    公开(公告)号：EP0372571A3

    公开(公告)日：1991-07-03

    申请号：EP89122689.6

    申请日：1989-12-08

    申请人： MECT CORPORATION

    发明人： Fujita, Shuji ,  Sugimoto, Mamoru ,  Ito, Masayoshi ,  Ogawa, Tomoya

    IPC分类号： C07C69/18 ,  C07C43/15 ,  C07C309/66 ,  C07C247/08 ,  C07C233/18 ,  C07C217/46 ,  C07H15/10

    CPC分类号： C07C43/178 ,  C07C69/145 ,  C07C217/46 ,  C07C233/18 ,  C07C247/08

    摘要： A sphingenine and derivatives thereof herein provided are represented by the following general formulas (I) and (II):
    in the formulas (I) and (II), R 1 represents a hydrogen atom, an acetyl group or a methanesulfonyl group; R 2 represents a hydrogen atom or an ethoxyethyl group; R 3 represents an azido group, an amino group, an alkylamido group, an arylamido group, an aralkylamido group or a tetracosanamido group; R 4 represents a hydrogen atom or an ethoxyethyl group; EE represents an ethoxy ethyl group; and n is an integer ranging from 1 to 22. These sphingenine and derivatives thereof are very useful as intermediates for synthesizing glycolipids and gangliosides which are effective as markers of tumours, in particular, in the preparation of ceramide parts of the glycolipids and gangliosides.

    Un-natural ceramide related compounds and preparation thereof
    9.
    发明公开
    Un-natural ceramide related compounds and preparation thereof 失效
    非天然神经酰胺相关化合物及其制备。

    公开(公告)号：EP0293006A1

    公开(公告)日：1988-11-30

    申请号：EP88108537.7

    申请日：1988-05-27

    申请人： MECT CORPORATION

    发明人： Fujita, Shuji ,  Yoshimura, Shoji ,  Ito, Masayoshi ,  Shitori, Yoshiyasu ,  Ogawa, Tomoya

    IPC分类号： C07C233/18 ,  C07C231/00

    CPC分类号： C07C233/16

    摘要： Novel unnatural ceramide related compounds, for instance, (2S, 3S)-2-tetracosanamido-octadecane-1,3-diol are herein provided, which are useful as intermediates in preparing ceramide moieties employed in the preparation of glycolipids and gangliosides known as tumor markers or molecular markers and which are prepared by, for instance, subjecting a chiral compound represented by the following formula:
    I to deacetal treatment.

    摘要翻译： 新颖的非天然神经酰胺相关化合物，例如，（2S，3S）-2-二十四十八烷-1,3-二醇在提供，其可用作称为肿瘤在制备糖脂和神经节苷脂的制备所用的神经酰胺部分的中间体 标记或分子标记和由制备，例如，使由下式表示的手性化合物：到deacetal治疗。 升