公开(公告)号：EP0176923B1

公开(公告)日：1990-04-04

申请号：EP85112067.5

申请日：1985-09-24

申请人： MILES INC.

发明人： Wogoman, Frank W.

IPC分类号： G01N33/48 ,  G01N35/00 ,  G01N31/22 ,  B65H3/00 ,  B65H29/00

CPC分类号： G01N35/00029 ,  B65H3/0808 ,  B65H29/006 ,  B65H2301/4191 ,  G01N2035/00089 ,  G01N2035/00108

公开(公告)号：EP0339277A1

公开(公告)日：1989-11-02

申请号：EP89105512.1

申请日：1989-03-29

申请人： MILES INC.

发明人： Wogoman, Frank W.

IPC分类号： G01N33/53 ,  G01N33/543 ,  G01N21/07

CPC分类号： G01N33/54366 ,  G01N21/07 ,  G01N33/5302 ,  G01N33/5304 ,  Y10S436/807 ,  Y10T436/111666

摘要： Analytical reagent reaction vessel and method for performing sequential analytical assay procedures to determine an analyte in a liquid test sample. The reaction vessel is in the form of a closed container having a substantially horizontal axis of rotation and incorporated with one or n:ore analytical reagents for performing a desired analytical assay procedure. The reaction vessel is designed to provide free gravitational movement of a liquid test sample disposed therein. The analytical reagents are incorporated into the reaction vessel such that they are contacted with a liquid test sample in a desired order or sequence. A liquid test sample disposed in the reaction vessel is capable of being manipulated therein by rotating the reaction vessel about the horizontal axis wherein the liquid test sample is transported by gravity. Accordingly, a liquid test sample can be sequentially contacted with the analytical reagents, and one or more of a detectable response can be measured, without the need for additional external manipulative steps or complicated instruments to complete the assay. The reaction vessel is particularly useful for performing immunoturbidimetric and immunometric assays.

摘要翻译： 分析试剂反应容器和用于执行顺序分析测定程序以确定液体测试样品中的分析物的方法。 反应容器是具有基本上水平的旋转轴线的密闭容器的形式，并结合有用于进行所需分析测定程序的一种或者n分析试剂。 反应容器被设计成提供设置在其中的液体测试样品的游离重力运动。 将分析试剂并入反应容器中，使得它们以所需的顺序或顺序与液体测试样品接触。 设置在反应容器中的液体测试样品能够通过围绕水平轴线旋转反应容器而被操纵，其中液体测试样品通过重力传送。 因此，液体测试样品可以与分析试剂顺序接触，并且可以测量一个或多个可检测的响应，而不需要额外的外部操作步骤或复杂的仪器来完成测定。 反应容器特别适用于进行免疫比浊和免疫测定。

公开(公告)号：EP0215419A3

公开(公告)日：1989-04-19

申请号：EP86112429.5

申请日：1986-09-08

申请人： MILES INC.

发明人： Blatt, Joel M. ,  Heiland, Robert ,  Morris, James R. ,  Pugh, Jerry T. ,  Wogoman, Frank W.

IPC分类号： B01L3/00 ,  G01N1/00

CPC分类号： B01L3/502738 ,  B01L3/5023 ,  B01L3/502746 ,  B01L2200/0605 ,  B01L2300/0825 ,  B01L2300/0887 ,  B01L2400/0406 ,  B29C65/08 ,  B29C66/1122 ,  B29C66/3022 ,  B29C66/543 ,  B29L2031/756

摘要： A method for volume metering of a liquid sample onto a reactive surface and a flow metering capillary device for controlled fluid flow comprising two opposing surface areas spaced apart throughout a capillary zone of intended liquid transport at a distance no greater than that which will maintain a capillary flow of liquid introduced therebetween, means to permit Introduction of a test specimen between these surfaces, there being formed between said opposing surfaces an overflow channel and an overflow chamber which draws any excess liquid from the means for introducing the liquid between the surfaces.