利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

23 条记录 (耗时 0.014 秒)

    Reaction cassette for performing sequential analytical assays by noncentrifugal and noncapillary manipulations
    1.
    发明公开
    Reaction cassette for performing sequential analytical assays by noncentrifugal and noncapillary manipulations 失效
    反应盒用于使用nichtzentrifugaler和nichtkapillarer操作顺序分析测定。

    公开(公告)号：EP0407827A2

    公开(公告)日：1991-01-16

    申请号：EP90112397.6

    申请日：1990-06-29

    申请人： MILES INC.

    发明人： Messenger, Lowry J. ,  Nelson, Christine D. ,  Wogoman, Frank W. ,  Yip, Kin-Fai

    IPC分类号： B01L3/00 ,  G01N33/53

    CPC分类号： B01L3/502 ,  B01L2200/0621 ,  B01L2400/0457 ,  G01N33/54366 ,  G01N33/723 ,  G01N33/726

    摘要： Analytical reaction cassette and method for performing sequential analytical assay procedures to determine the amount of an analyte in a liquid test mixture. The reaction cassette (10) can be in the form of a substantially square container having a substantially horizontal axis of rotation and incorporated with one or more analytical reagents such that they are contacted with a liquid test mixture in a desired ordered sequence to perform a particular assay procedure. Corners (22-24) provided by the substantially square configuration of the reaction cassette disrupt the flow of liquids disposed in the reaction cassette upon contact therewith to thereby agitate and mix such liquids. A liquid disposed in the reaction cassette is capable of being manipulated and mixed therein by rotating the reaction cassette about the horizontal axis at sufficiently low velocities wherein the transport of such liquid is noncentrifugal and due substantially only to gravitational force. The reaction cassette is particularly useful for performing immunoturbidimetric assays, e.g., for the determination of glycated hemoglobin.

    摘要翻译： 分析反应盒和用于在液体测试混合物执行顺序分析测定程序，以确定一个矿井分析物的量的方法。 该反应盒可以是具有旋转的基本水平的轴线，并与一种或多种分析试剂寻求GDP是可以用在期望的有序序列的液体测试混合物以执行特定测定程序接触并入大致正方形容器的形式。 通过反应盒的大致正方形的配置提供角部破坏在反应盒时接触，从而搅拌并混合液体检查设置在它们的液体的流动。 在反应盒设置在液体能够被操纵的，并通过在足够低的速度绕水平轴的反应盒混入其中​​worin的液体输送仅到重力寻求非离心，并且由于基本上。 所述反应盒是用于执行测定免疫比浊，E. G.，糖化血红蛋白的测定是特别有用的。

    Fluid separation and processing device
    2.
    发明公开
    Fluid separation and processing device 失效
    Trennungs- und BehandlungsvorrichtungfürFlüssigkeiten。

    公开(公告)号：EP0297394A2

    公开(公告)日：1989-01-04

    申请号：EP88109832.1

    申请日：1988-06-21

    申请人： MILES INC.

    发明人： Wogoman, Frank W.

    IPC分类号： B04B5/04 ,  B04B5/02

    CPC分类号： B01L3/50273 ,  B01L2200/0621 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2400/0409 ,  B04B5/0407 ,  G01N2035/00495 ,  Y10T436/111666

    摘要： An assembly (10) for separating, metering and delivering fluids includes a central rotating member (12) rotatable about a fixed spin axis (14). A processing chamber holding member is connected to the central rotating member (12) by a centrifugally actuated frame (30). At rotational speeds below a first predetermined speed, the centrifugally actuated frame (30) is in a first position. At rotational speeds greater than the first speed, centrifugal force moves the frame (30) to a second position angularly spaced from and at greater distance from the spin axis (14) than the first position. A processing chamber (60) is mounted on the holding member (26, 28) and its orientation relative to the spin axis (14) is the same in the first and second positions. Fluid is provided in the processing chamber (60). By accelerating the processing chamber (60) to the first predetermined speed and decelerating below the first predetermined speed in a selected sequence, specific centrifugal force vectors are generated in the processing chamber (60) that move the fluid (70) and retain it in selected chambers (90, 96, 104, 120). During this sequence, the fluid (70) is metered, separated and delivered to a reduction area (138) where measuring is performed.

    摘要翻译： 用于分离，计量和输送流体的组件（10）包括可围绕固定旋转轴线（14）旋转的中心旋转构件（12）。 处理室保持构件通过离心致动框架（30）连接到中心旋转构件（12）。 在低于第一预定速度的转速下，离心致动框架（30）处于第一位置。 在大于第一速度的旋转速度下，离心力将框架（30）移动到与第一位置成角度间隔开并且与旋转轴线（14）成比较大距离的第二位置。 处理室（60）安装在保持构件（26,28）上，并且其相对于旋转轴线（14）的取向在第一和第二位置是相同的。 流体设置在处理室（60）中。 通过将处理室（60）加速到第一预定速度并以选定的顺序减速到低于第一预定速度，在处理室（60）中产生特定的离心力矢量，其移动流体（70）并将其保持在选定的 （90,96,104,120）。 在该顺序期间，流体（70）被计量，分离并输送到执行测量的还原区域（138）。

    Apparatus for moving a member along an orbital path
    3.
    发明公开
    Apparatus for moving a member along an orbital path 失效
    Vorrichtung zum Bewegen eines Teils entlang einer geschlossenen Kurve。

    公开(公告)号：EP0430305A2

    公开(公告)日：1991-06-05

    申请号：EP90123170.4

    申请日：1985-08-30

    申请人： MILES INC.

    发明人： Khoja, Mirza A. ,  Wogoman, Frank W.

    IPC分类号： G01N35/00 ,  B65G25/02

    CPC分类号： G01N35/00029 ,  B65G25/02 ,  G01N1/2813 ,  G01N21/8483 ,  G01N2035/00039 ,  G01N2035/00118 ,  Y10T436/112499 ,  Y10T436/113332

    摘要： A multiple reagent test strip-reading instrument having rails extending from a loading area to one or more reading station platforms and thence to a waste receptacle, a reciprocating blotter arm which contacts individual reagent strips sequentially placed trans­versely on the rails in the loading area, moving individual strips along the rails to an indexing strip advancing mechanism which intermittently advances the strips along the rails in spaced parallel relation, and after each advance, allows the strips to dwell for a predetermined time period; individual test strips being thereby sequentially delivered to reading position on the reading station platform where, during the dwell period, they are read by reflectance photo­metry. After reading, the strips are moved to the waste receptacle. Means is provided for insuring that each test strip is delivered to reading position in registration with the read head of the photometer, and means is also provided for pressing each test strip flat against the reading station platform. The indexing mechanism employs a strip advancing member provided with parallel rows of equally spaced upstanding pegs or fingers, there being guiding and drive means for imparting movement to said member along a vertical orbital path having a generally circular extent and also having a rectilinear extent parallel with the rails, said pegs intersecting the plane of the reagent srips on the rails when said member moves forwardly along said rectilinear extent and being withdrawn from said plane when said member moves rearwardly along said circular extent.

    摘要翻译： 一种多试剂测试条读取仪器，其具有从装载区域延伸到一个或多个阅读站平台的导轨，然后到达废物容器，一个往复式吸墨纸臂，其接触各个试剂条，其横向地放置在装载区域中的轨道上，移动 沿着轨道的单个条带到分段条带前进机构，其间隔地平行地沿着轨道推进条带，并且在每个提前之后允许条带停留预定时间段; 单独的测试条由此顺序地传送到阅读台平台上的读取位置，在停留期间，它们通过反射光度测量被读取。 阅读后，条带移动到废物容器。 提供了用于确保每个测试条被传送到与光度计的读取头对准的读取位置的装置，并且还提供用于将每个测试条平放在读取台平台上的装置。 分度机构采用设置有平行的等间隔直立的钉或手指的条带推进构件，存在引导和驱动装置，用于沿着具有大致圆形范围的垂直轨道路径向所述构件施加运动，并且还具有与 所述导轨，当所述构件沿着所述直线范围向前移动时，所述栓与所述导轨上的试剂滑块的平面相交，并且当所述构件沿着所述圆形程度向后移动时从所述平面撤回。

    Reagent test strip reading instrument
    4.
    发明公开
    Reagent test strip reading instrument 失效
    试剂试纸读数仪

    公开(公告)号：EP0428184A2

    公开(公告)日：1991-05-22

    申请号：EP90123167.0

    申请日：1985-08-30

    申请人： MILES INC.

    发明人： Khoja, Mirza A. ,  Wogoman, Frank W.

    IPC分类号： G01N35/00 ,  G01N21/86

    CPC分类号： G01N35/00029 ,  B65G25/02 ,  G01N1/2813 ,  G01N21/8483 ,  G01N2035/00039 ,  G01N2035/00118 ,  Y10T436/112499 ,  Y10T436/113332

    摘要： A multiple reagent test strip-reading instrument having rails extending from a loading area to one or more reading station platforms and thence to a waste receptacle, a reciprocating blotter arm which contacts individual reagent strips sequentially placed trans­versely on the rails in the loading area, moving individual strips along the rails to an indexing strip advancing mechanism which intermittently advances the strips along the rails in spaced parallel relation, and after each advance, allows the strips to dwell for a predetermined time period; individual test strips being thereby sequentially delivered to reading position on the reading station platform where, during the dwell period, they are read by reflectance photo­metry. After reading, the strips are moved to the waste receptacle. Means is provided for insuring that each test strip is delivered to reading position in registration with the read head of the photometer, and means is also provided for pressing each test strip flat against the reading station platform. The indexing mechanism employs a strip advancing member provided with parallel rows of equally spaced up standing pegs or fingers, there being guiding and drive means for imparting movement to said member along a vertical orbital path having a generally circular extent and also having a rectilinear extent parallel with the rails, said pegs intersecting the plane of the reagent strips on the rails when said member moves forwardly along said rectilinear extent and being withdrawn from said plane when said member moves rearwardly along said circular extent.

    摘要翻译： 一种多试剂测试条读取仪器，具有从装载区延伸到一个或多个读取站平台并由此到达废物容器的轨道，往复吸墨臂与单个试剂条接触，顺序横向放置在装载区中的轨道上， 沿着轨道的单个带到分度带推进机构，该分度带推进机构以间隔平行的关系沿着轨道间歇地推进带，并且在每次前进之后，允许带停留预定时间段; 由此将单独的测试条顺序输送到阅读台平台上的阅读位置，在阅读台平台期间，在停留期间，它们通过反射光度法读取。 读数后，条被移动到废物容器。 提供了用于确保每个测试条被传送到与光度计的读取头对齐的读取位置的装置，并且还提供了用于将每个测试条平靠在读取台平台上的装置。 分度机构采用带有平行排的等距立起钉或指状物的带材推进构件，其中具有引导和驱动装置，用于沿着具有大致圆形范围的垂直轨道路径对所述构件施加运动，并且还具有平行的直线范围 当所述构件沿着所述直线延伸部向前移动时，所述栓与试剂条平面在轨道上相交，并且当所述构件沿着所述环形延伸部向后移动时，所述栓从所述平面撤回。

    Automated handling system
    7.
    发明公开
    Automated handling system 失效
    自动搬运装置。

    公开(公告)号：EP0176923A2

    公开(公告)日：1986-04-09

    申请号：EP85112067.5

    申请日：1985-09-24

    申请人： MILES INC.

    发明人： Wogoman, Frank W.

    IPC分类号： G01N33/48 ,  G01N35/00 ,  G01N31/22 ,  B65H3/00 ,  B65H29/00

    CPC分类号： G01N35/00029 ,  B65H3/0808 ,  B65H29/006 ,  B65H2301/4191 ,  G01N2035/00089 ,  G01N2035/00108

    摘要： Apparatus and process are disclosed for removing a single flexible member from a storage spool capable of holding multiple flexible members. This storage spool.is designed to contain multiple elongated flexible members in an accurate position on the spool by means of radial channels or slots where the flexible members are held in place by interwinding material. By removing the interwinding material on a take up spool the individual flexible member can be positioned for removal from the storage spool by a pick up head or vacuum transport member. The invention has particular applicability to the handling of test devices, such as reagent strips, used in the determination of a biological constituent in a body fluid.