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21.发明授权
公开(公告)号：EP1591505B1
公开(公告)日：2007-02-28
申请号：EP05009134.7
申请日：2005-04-26
发明人： Inosaka, Keigo , Muraoka, Takateru
IPC分类号： C09J133/06 , A61L15/58
CPC分类号： A61L15/585 , C08L33/04 , C08L2205/02 , C08L2666/06 , C09J133/14 , C08L39/06 , C08L33/06
摘要： A medical non-crosslinked pressure-sensitive adhesive composition which not only has relatively high resistance to water during perspiration or the like and shows a sufficient skin adhesive force, but also can contain a large amount of a liquid plasticizer and hence have reduced skin-irritating properties. These compositions comprise an adhesive polymer A having a weight-average molecular weight of 500,000-1,000,000, an adhesive polymer B having a weight-average molecular weight of 1,000,000-1,500,000, and a liquid plasticizer, wherein the adhesive polymer A is a polymer obtained by copolymerizing one or more alkyl (meth)acrylates with N-vinyl-2-pyrrolidone and the adhesive polymer B is either a polymer obtained by the polymerization of one or more alkyl (meth)acrylates or a polymer obtained by copolymerizing one or more alkyl (meth)acrylates with one or more comonomers other than N-vinyl-2-pyrrolidone. Also provided are a medical adhesive sheet and a process for producing the medical non-crosslinked pressure-sensitive adhesive composition.
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公开(公告)号：EP0904778B1
公开(公告)日：2003-05-02
申请号：EP98116798.4
申请日：1998-09-04
CPC分类号： A61K9/7053 , A61K9/0014 , A61K9/7061 , A61K47/14 , A61K47/22
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公开(公告)号：EP2135905A3
公开(公告)日：2013-08-07
申请号：EP09162693.7
申请日：2009-06-15
IPC分类号： C09J7/02 , A61K9/70 , C08K5/09 , C09J139/06
CPC分类号： C09J139/06 , A61K9/7061 , C08K3/16 , C08K5/09 , C08L2666/02 , C09J7/38 , C09J2205/102 , C09J2433/00
摘要： The present invention provides a patch capable of suppressing adhesive residue on the skin surface upon peeling off from the skin in the presence of water due to perspiration and the like, as well as easy detachment from the skin in the presence of water due to perspiration and the like. The present invention provides a patch comprising a support and an adhesive layer provided on at least one surface of the support, wherein the adhesive layer is formed by crosslinking a blend of the following component (A) to component (D): (A) a copolymer obtained by copolymerization of a monomer containing a carboxyl group, (meth)acrylate and vinylpyrrolidone as essential components; (B) a copolymer obtained by copolymerization of a monomer having a basic group as an essential component; (C) a liquid component, and (D) an acidic compound.
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公开(公告)号：EP2364695A1
公开(公告)日：2011-09-14
申请号：EP10153194.5
申请日：2010-02-10
发明人： Hara, Takumi , Tamura, Kei , Inosaka, Keigo , Saeki, Yuji
IPC分类号： A61K9/70 , A61K31/4458
CPC分类号： A61K9/7053 , A61K31/4458
摘要： Provided is a methylphenidate patch preparation superior in the stability of a drug (methylphenidate and/or a salt thereof) in the patch preparation, skin permeability of a drug during use of the patch preparation, and methylphenidate availability. A patch preparation having a support and an adhesive layer formed on at least one surface of the support, wherein the adhesive layer contains methylphenidate and/or a salt thereof, polyisobutylene and a liquid plasticizer. The liquid plasticizer preferably has an HLB value of 1.0 - 3.3.
摘要翻译： 本发明提供了贴剂制剂中药物（哌甲酯和/或其盐）的稳定性优异的哌甲酯贴片制剂，贴剂制剂使用期间药物的皮肤透过性和哌甲酯可用性。 一种贴片制剂，其具有在所述支持体的至少一个表面上形成的载体和粘合剂层，其中所述粘合剂层含有哌甲酯和/或其盐，聚异丁烯和液体增塑剂。 液体增塑剂优选具有1.0-3.3的HLB值。
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26.发明公开
公开(公告)号：EP2110125A1
公开(公告)日：2009-10-21
申请号：EP09158023.3
申请日：2009-04-16
发明人： Tamura, Kei , Inosaka, Keigo , Saeki, Yuji
IPC分类号： A61K9/70 , A61K31/565
CPC分类号： A61K31/565 , A61K9/7053 , A61K9/7092
摘要： The present invention provides a transdermal drug administration device capable of freely controlling release of the drug. The transdermal drug administration device of the present invention contains a backing layer and a matrix layer provided on at least one surface of the backing layer, wherein the matrix layer contains a region located on a proximal side from the backing layer and a region located on a distal side from the backing layer, and the water-absorbing polymers therein have different weight concentrations, which enables high control of a drug released from the device.
摘要翻译： 本发明提供能够自由地控制药物释放的透皮给药装置。 本发明的透皮给药装置包含背衬层和设置在背衬层的至少一个表面上的基质层，其中基质层包含位于背衬层的近侧的区域和位于背衬层上的区域 并且其中的吸水性聚合物具有不同的重量浓度，这使得能够高度控制从该装置释放的药物。
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公开(公告)号：EP1970079A3
公开(公告)日：2009-06-17
申请号：EP08250660.1
申请日：2008-02-27
CPC分类号： A61L24/0015 , A61L15/58 , A61L24/04 , A61L2300/402
摘要： The present invention aims at providing an adhesive preparation wherein a drug is sufficiently dissolved in an adhesive layer and is not easily separated from the adhesive layer even during preservation of the adhesive preparation.
The present invention provides an adhesive preparation having an adhesive layer on at least one surface of a support, wherein the adhesive layer comprises a first synthetic rubber having a viscosity average molecular weight of 1,600,000 - 6,500,000, a drug, an organic liquid component and a tackifier. The present invention further provides the aforementioned adhesive preparation, wherein the organic liquid component is contained in the adhesive layer in a proportion of 20 wt% or above relative to the total weight of the adhesive layer.-
28.发明授权Percutaneous absorption-type pharmaceutical preparation using a metal chloride, preferably sodium chloride, for preventing cohesive failure 有权使用金属氯化物，优选氯化钠的经皮吸收型药物制剂，用于防止内聚破坏
公开(公告)号：EP1733719B1
公开(公告)日：2008-11-26
申请号：EP06011300.8
申请日：2006-05-31
IPC分类号： A61K9/70 , A61K31/275 , A61K47/02
CPC分类号： A61K31/275 , A61K9/7061 , A61K47/02
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29.发明公开Percutaneous absorption-type pharmaceutical preparation using a metal chloride, preferably sodium chloride, for preventing cohesive failure 有权使用金属氯化物，优选氯化钠，用于防止粘合的弱点用于经皮吸收的药物组合物
公开(公告)号：EP1733719A1
公开(公告)日：2006-12-20
申请号：EP06011300.8
申请日：2006-05-31
IPC分类号： A61K9/70 , A61K31/275 , A61K47/02
CPC分类号： A61K31/275 , A61K9/7061 , A61K47/02
摘要： A stable percutaneous absorption-type pharmaceutical preparation for percutaneous administration of drugs except for selegiline and selegiline hydrochloride, which does not suffer a decrease in the cohesive force of the adhesive layer therein even in the presence of sweat components due to perspiration during wear and which is free from cohesive failure and resultant adhesive remaining when stripped off. A percutaneous absorption-type pharmaceutical preparation which comprises: a support; and an adhesive layer containing an adhesive, a metal chloride and a percutaneously-absorptive drug except for selegiline and selegiline hydrochloride, wherein the adhesive layer is subjected to a crosslinking treatment.
摘要翻译： 对于除司来吉兰和司来吉兰盐酸盐，其不遭受在该粘合剂层的。其中，即使在汗液组分存在的凝聚力下降，由于穿戴期间汗水的药物经皮给药和稳定的经皮吸收型药物制剂的所有其 从内聚破坏和粘合剂剩余的合力自由当剥离，其包括经皮吸收型药物制剂：支撑;. 和粘合剂层含的粘合剂，金属氯化物和除了司来吉兰和司来吉兰盐酸盐的经皮吸收药物，worin粘合剂层进行交联处理。
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公开(公告)号：EP1717287A1
公开(公告)日：2006-11-02
申请号：EP06008578.4
申请日：2006-04-26
IPC分类号： C09J133/08 , C09J133/10 , C09J7/02
CPC分类号： C09J133/14 , Y10T428/2891 , Y10T428/31935
摘要： The present invention provides an adhesive capable of affording an adhesive layer showing reduced stickiness, reduced cohesive failure and the like. An adhesive containing a copolymer obtained by copolymerizing monomers containing a (meth)acrylic acid alkyl ester as a main component, and a vinyl monomer having a hydroxyl group and/or a carboxyl group and which has an average molecular radius of not less than 70 nm as measured by a multi angle laser light scattering method.
摘要翻译： 本发明提供一种能够提供粘合剂层的粘合剂，其显示出降低的粘性，减少的内聚破坏等。 含有通过使含有（甲基）丙烯酸烷基酯作为主要成分的单体和具有羟基和/或羧基的乙烯基单体共聚而得到的共聚物的粘合剂，其平均分子量不小于70nm 通过多角度激光散射法测量。
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