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    ADENOSINE COMPOUND, PHARMACEUTICALLY ACCEPTABLE SALT OR STEREOISOMERIDE THEREOF, AND USE
    21.
    发明公开
    ADENOSINE COMPOUND, PHARMACEUTICALLY ACCEPTABLE SALT OR STEREOISOMERIDE THEREOF, AND USE 审中-公开

    公开(公告)号：EP3988100A1

    公开(公告)日：2022-04-27

    申请号：EP20826924.1

    申请日：2020-06-22

    申请人： Academy Of Military Medical Sciences

    发明人： ZHONG, Wu ,  ZHANG, Min ,  ZHOU, Xinbo ,  FAN, Shiyong ,  LI, Song

    IPC分类号： A61K31/52 ,  C07H19/167 ,  A61P9/08 ,  A61P9/10 ,  A61P37/00

    摘要： The present invention relates to a compound represented by Formula I, its pharmaceutically acceptable salt, its stereoisomer, its pharmaceutically acceptable hydrate or solvate, or its pharmaceutically acceptable ester, wherein R is selected from heteroaryl, substituted heteroaryl, aryl, substituted aryl, cycloalkyl, substituted cycloalkyl, alkyl, and substituted alkyl, wherein the substituted heteroaryl, the substituted aryl, the substituted cycloalkyl and the substituted alkyl are each independently substituted with one or more hydroxyalkylene groups. The compound or its pharmaceutically acceptable salt, its stereoisomer, its pharmaceutically acceptable hydrate or solvate, its pharmaceutically acceptable ester of the present invention has agonistic activity on A 2A adenosine receptor and can improve the permeability of blood-brain barrier to promote the delivery of drug across blood-brain barrier, and can also prevent or treat a disease associated with A 2A adenosine receptor agonistic activity.