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1.发明授权
公开(公告)号：EP3153165B1
公开(公告)日：2020-05-06
申请号：EP15803906.5
申请日：2015-06-03
发明人： ZHONG, Wu , LI, Song , CAO, Shuang , CAO, Ruiyuan , XIAO, Junhai , ZHOU, Xinbo , LI, Xingzhou
IPC分类号： A61K31/395 , C07D405/14 , C07D405/00 , C07D491/18
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公开(公告)号：EP2955174B1
公开(公告)日：2019-02-27
申请号：EP13874809.0
申请日：2013-12-10
发明人： LI, Song , XIAO, Junhai , ZHAO, Mingming , ZHONG, Wu , WANG, Lili , ZHENG, Zhibing , XIE, Yunde , LI, Xingzhou , ZHAO, Guoming , ZHOU, Xinbo , WANG, Xiaokui , CHEN, Wei
IPC分类号： C07D307/33 , A61K31/635 , A61P31/04
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公开(公告)号：EP3085701B1
公开(公告)日：2019-02-20
申请号：EP14872369.5
申请日：2014-12-19
发明人： ZHONG, Wu , LI, Song , ZENG, Yanqun , XIAO, Junhai , ZHOU, Xinbo , ZHENG, Zhibing , LI, Xingzhou , WANG, Xiaokui , WANG, Lili
IPC分类号： C07D401/04 , C07D417/06 , A61K31/506 , A61K31/454 , A61P35/00 , A61P25/28 , A61P37/06 , A61P31/00
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4.发明授权DERIVATES OF SUBSTITUTED TARTARIC AICD AND USAGE FOR PREPARATING BETA SECRETASE INHIBITORS 有权取代的酒石酸衍生物的衍生物和用于制备β分泌酶抑制剂的用途
公开(公告)号：EP2116526B1
公开(公告)日：2018-04-18
申请号：EP07702276.2
申请日：2007-02-05
发明人： LI, Song , LIAO, Guochao , XIAO, Junhai , NIE, Aihua , WANG, Lili , ZHONG, Wu , ZHENG, Zhibing
IPC分类号： C07C235/12 , C07D241/04 , A61K31/16 , A61K31/4965 , A61P25/28 , A61P25/00 , A61P43/00 , C07D235/06
CPC分类号： C07C235/16 , C07C235/12 , C07C237/42 , C07C2601/14 , C07D235/06 , C07D295/185
摘要： The present invention relates to compounds represented by formula (I), or isomers, prodrugs, pharmaceutically acceptable salts, solvates or hydrates thereof: in which each substituent of formula (I) is as defined in the specification. The present invention also relates to preparation methods of compounds represented by formula (I), a pharmaceutical composition comprising compounds represented by formula (I) and usage of compounds represented by formula (I) for treating chronic neurodegenerative diseases such as Alzheimer's disease and other diseases induced by aggregation or deposition of ²-amyloid peptide.
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5.发明授权THIAZINE AMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION AND USE THEREOF 有权THAZINAMIDDERIVAT SOWIE PHARMAZEUTISCHE ZUSAMMENSETZUNG UND VERWENDUNG DAVON
公开(公告)号：EP2889293B1
公开(公告)日：2017-04-26
申请号：EP12883262.3
申请日：2012-08-24
发明人： LI, Song , XIAO, Junhai , HAN, Dan , ZHONG, Wu , WANG, Lili , ZHENG, Zhibing , XIE, Yunde , ZHOU, Xinbo , LI, Xingzhou , WANG, Xiaokui , JIANG, Dan , CHEN, Wei , LIU, Hongying
CPC分类号： C07D279/12
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6.发明公开
公开(公告)号：EP3085700A1
公开(公告)日：2016-10-26
申请号：EP14871647.5
申请日：2014-12-19
发明人： ZHONG, Wu , LI, Song , ZENG, Yanqun , XIAO, Junhai , ZHOU, Xinbo , ZHENG, Zhibing , LI, Xingzhou , WANG, Xiaokui
IPC分类号： C07D401/04 , C07D401/14 , C07D409/14 , A61K31/506 , A61P35/00 , A61P25/28 , A61P37/06 , A61P31/04
CPC分类号： C07D401/04 , A61K31/404 , A61K31/454 , A61K31/4545 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K45/06 , C07D401/14 , C07D409/14 , A61K2300/00
摘要： The present invention provides a compound of a general formula I, a stereomeride, pharmaceutically acceptable salt or a solvate thereof, a preparation method thereof, and usages in preparing medicines for preventing and/or treating diseases or symptoms caused by drug-resistant tumors or drug-resistant bacteria and in preparing medicines for preventing and/or treating diseases or symptoms related to tumors, neurodegenerative diseases, allogeneic transplantation rejection, and infection. Preferably, the diseases or symptoms related to tumors, neurodegenerative diseases, allogeneic transplantation rejection, and infection are diseases or symptoms caused by a heat shock protein 70 (Hsp70). The compound in the present invention is used for overcoming a difficult problem of drug resistance of tumors, improves the effect of tumor treatment, and provides a new medical strategy for clinical tumor treatment.
摘要翻译： 本发明提供了通式I的化合物，其立体异构体，药学上可接受的盐或溶剂合物，其制备方法以及用于制备用于预防和/或治疗由耐药肿瘤或药物引起的疾病或症状的药物的用途 和制备用于预防和/或治疗与肿瘤，神经退行性疾病，异体移植排斥和感染有关的疾病或症状的药物。 优选地，与肿瘤，神经退行性疾病，同种异体移植排斥和感染有关的疾病或症状是由热休克蛋白70（Hsp70）引起的疾病或症状。 本发明化合物用于克服肿瘤耐药性难题，提高肿瘤治疗效果，为临床肿瘤治疗提供了新的医学策略。
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7.发明公开SUSTAINED RELEASE COMPOSITION CONTAINING TETRAHYDROPYRIDO Ý4, 3-b¨INDOLE DERIVATIVE AND PREPARATION METHOD OF DERIVATIVE 有权RETARDZUSAMMENSETZUNG MIT TETRAHYDROPYRIDO [4,3-B] INDOL-DERIVAT
公开(公告)号：EP2417973A1
公开(公告)日：2012-02-15
申请号：EP10761171.7
申请日：2010-03-29
发明人： LI, Song , ZHONG, Wu , ZHENG, Zhibing , XIAO, Junhai , LI, Bing , XIE, Yunde , ZHOU, Xinbo
IPC分类号： A61K31/44 , A61K9/22 , A61K9/52 , A61P25/28 , C07D471/04
CPC分类号： A61K31/44 , A61K9/1641 , A61K9/2031 , A61K9/2077 , C07D471/04
摘要： The present invention relates to a sustained-release composition containing 2,3,4,5-tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole or a pharmaceutically acceptable salt thereof as an active ingredient, preparation thereof and the compound. The composition is suitable for oral administration by one time per day, and achieves the peak plasma concentration at 1.0 to 3 hours after oral administration. The composition is suitable for manufacturing a medicament for treatment of cognitive dysfunction syndrome, Alzheimer's disease, Parkinson's disease, Huntington's disease, or senile dementia.
摘要翻译： 本发明涉及含有2,3,4,5-四氢-2,8-二甲基-5- [2-（6-甲基-3-吡啶基）乙基] -1H-吡啶并[4,1- 3-b]吲哚或其药学上可接受的盐作为活性成分，其制备和化合物。 该组合物适合于每天一次口服给药，口服后1.0〜3小时达到峰值血药浓度。 该组合物适用于制造用于治疗认知功能障碍综合征，阿尔茨海默氏病，帕金森病，亨廷顿病或老年痴呆的药物。
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公开(公告)号：EP2005945A9
公开(公告)日：2009-07-01
申请号：EP06775361.6
申请日：2006-08-11
发明人： LI, Song , ZHONG, Wu , XIAO, Junhai , XIE, Yunde , LI, Xingzhou , CUI, Hao , ZHENG, Zhibing
CPC分类号： A61K31/215 , A61K9/0056 , A61K9/0095 , A61K9/141 , A61K9/1623 , A61K9/1635 , A61K9/1652
摘要： The present invention relates to an oseltamivir phosphate granule and preparation method thereof. The said granule comprises 1.97-19.8 wt.% oseltamivir phosphate, 75.0-97.5 wt.% diluent, 0.1-5.0 wt.% binder, optionally 1.0-5.0 wt.% edible flavouring essence, sweetener and/or edible pigment. It is prepared by using 30-55v/v% aqueous ethanol solution as moistening agent. The granules prepared by the formulation and method according to the present invention have good uniformity and stability and are water-soluble. The administration dosage of the granules can be conveniently selected based on the age and body weight of patients. The oseltamivir phosphate granule is suitable for administering to old people, children and flu gravis patients and those patients that swallow inconveniently or difficultly. The preparation of the granule is simple and low in production cost.
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9.发明公开2,4,5-TRISUBSTITUTED THIAZOLE COMPOUNDS,PREPARATION METHODS, PHARMACEUTICAL COMPOSITIONS AND MEDICAL USES THEREOF 有权2,4,5-三取代的噻唑，方法，药物组合物和医疗应用THEREOF
公开(公告)号：EP2042494A1
公开(公告)日：2009-04-01
申请号：EP06775389.7
申请日：2006-08-15
发明人： LI, Song , GUO, Changbin , JIANG, Xiancheng , XIAO, Junhai , ZHONG, Wu
IPC分类号： C07D277/46 , C07D277/44 , C07D277/40 , C07D417/04 , A61K31/426 , A61P7/00 , A61P9/00 , A61P9/10
CPC分类号： C07D277/40 , C07D277/24 , C07D277/42 , C07D277/44 , C07D277/46 , C07D277/50 , C07D277/52
摘要： The present invention relates to 2,4,5-trisubstituted thiazole compounds of formula (I) or all possible isomers, prodrugs, pharmaceutically acceptable salts, solvates or hydrates thereof for the inhibition of plasma PLTP activity and/or plasma CETP activity, wherein the substituents are as defined in the specification; a process for the preparation of the compounds of formula (I); a pharmaceutical composition comprising the compound of formula (I) and its use for the preparation of a medicament for treatment and/or prevention of diseases associated with the increased plasma PLTP activity and/or the increased plasma CETP activity in a mammal, such as atherosclerosis, cardiovascular diseases and peripheral vascular diseases, etc.
摘要翻译： 本发明涉及式（I）或所有可能的异构体，前药，药学上可接受的盐，溶剂化物或用于等离子体PLTP活性和/或血浆CETP活性的抑制它们的水合物2,4,5-三取代的噻唑化合物，该worin 取代基如说明书中所定义; 对于式（I）的化合物的制备方法; 的药物组合物，其包含式（I）的化合物和其用于治疗和/或预防与哺乳动物中的所述增加的血浆PLTP活性和/或增加的血浆CETP活性相关的疾病，：例如动脉粥样硬化的药物的制备中使用 ，心血管疾病和周边血管疾病等。
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公开(公告)号：EP2829270B1
公开(公告)日：2020-11-11
申请号：EP13764754.1
申请日：2013-03-22
发明人： LI, Song , GAO, Chunsheng , ZHONG, Wu , WANG, Yuli , YANG, Meiyan , SHAN, Li , ZHOU, Xinbo , ZHENG, Zhibing , WANG, Xiaokui
IPC分类号： A61K31/357 , A61K31/137 , A61K9/30 , A61K9/16 , A61P3/04 , A61K9/50
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