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公开(公告)号：EP2955174B1
公开(公告)日：2019-02-27
申请号：EP13874809.0
申请日：2013-12-10
发明人： LI, Song , XIAO, Junhai , ZHAO, Mingming , ZHONG, Wu , WANG, Lili , ZHENG, Zhibing , XIE, Yunde , LI, Xingzhou , ZHAO, Guoming , ZHOU, Xinbo , WANG, Xiaokui , CHEN, Wei
IPC分类号： C07D307/33 , A61K31/635 , A61P31/04
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公开(公告)号：EP2952509B1
公开(公告)日：2018-06-13
申请号：EP13874396.8
申请日：2013-12-10
发明人： LI, Song , XIAO, Junhai , ZHAO, Mingming , ZHONG, Wu , WANG, Lili , ZHENG, Zhibing , XIE, Yunde , LI, Xingzhou , ZHAO, Guoming , ZHOU, Xinbo , WANG, Xiaokui , CHEN, Wei
IPC分类号： C07D263/26 , A61K31/421 , A61P31/04
CPC分类号： C07D263/26 , A61K31/421 , A61K45/06 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478
摘要： The invention relates to a compound of formula I, and a preparation method and use thereof. The compound has a bacterial quorum-sensing regulatory effect, and can be used for prevention and/or treatment of a disease caused by a bacterial infection.
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公开(公告)号：EP2805947A1
公开(公告)日：2014-11-26
申请号：EP13738361.8
申请日：2013-01-15
申请人： Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China , Peking University
发明人： LI, Song , WANG, Ying , XIAO, Junhai , MA, Dalong , GONG, Hongwei , QI, Hui , WANG, Lili , LING, Xiaomei , ZHENG, Zhibing , ZHANG, Yang , ZHONG, Wu , LI, Meina , XIE, Yunde , XU, Enquan , LI, Xingzhou , MA, Jing , ZHAO, Guoming , ZHOU, Xinbo , WANG, Xiaokui , LIU, Hongying
IPC分类号： C07D403/14 , A61K31/506 , A61K31/519 , A61P11/06 , A61P17/00
CPC分类号： C07D471/04 , C07D239/50 , C07D401/12 , C07D403/12 , C07D403/14 , C07D417/12
摘要： Provided are piperazinyl pyrimidine derivatives of formula I having CCR 4 antagonism, and the preparation method, pharmaceutical composition and use thereof in the preparation of a medicament. The medicament is useful for the treatment and prevention of CCR 4 -related diseases.
摘要翻译： 本发明提供了具有CCR4拮抗作用的式I的哌嗪基嘧啶衍生物及其制备方法，药物组合物和其在制备药物中的用途。 该药物可用于治疗和预防CCR4相关疾病。
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4.发明公开PYRIDAZINE DERIVATIVES AND USE THEREOF AS MEDICAMENTS FOR TREATING MICRORNA VIRAL INFECTION 有权哒嗪和它们作为药物的微RNA病毒感染的治疗
公开(公告)号：EP2602252A1
公开(公告)日：2013-06-12
申请号：EP11814093.8
申请日：2011-08-02
发明人： LI, Song , WANG, Hongliang , XIAO, Junhai , ZHANG, Xian , WANG, Lili , ZHENG, Zhibing , ZHONG, Wu , XIE, Yunde , LI, Xingzhou , ZHOU, Xinbo , ZHAO, Guoming , WANG, Xiaokui
IPC分类号： C07D401/04 , A61K31/501 , A61P31/16
CPC分类号： C07D237/20
摘要： Disclosed are pyridazine derivatives represented by formula I or pharmaceutically acceptable salts or hydrates thereof, pharmaceutical compositions comprising the compounds, and the use of the compounds in preparing the medicaments for treating and/or preventing diseases or disorders associated with viral infections. The compounds represented by formula I have antiviral activity, especially anti-microRNA viral activity. Symbols in the compounds represented are described in the specification.
摘要翻译： 本发明公开了哒嗪衍生物由式I或其药学上可接受的盐或它们的水合物，药物组合物包含所述化合物，和在制备药物用于治疗和/或预防与病毒感染相关的疾病或病症中使用的化合物。 由式I化合物具有抗病毒活性，尤其是爱抗病毒微小RNA活性。 符号所表示的化合物中的描述在说明书中。
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公开(公告)号：EP2952509A1
公开(公告)日：2015-12-09
申请号：EP13874396.8
申请日：2013-12-10
发明人： LI, Song , XIAO, Junhai , ZHAO, Mingming , ZHONG, Wu , WANG, Lili , ZHENG, Zhibing , XIE, Yunde , LI, Xingzhou , ZHAO, Guoming , ZHOU, Xinbo , WANG, Xiaokui , CHEN, Wei
IPC分类号： C07D263/26 , A61K31/421 , A61P31/04
CPC分类号： C07D263/26 , A61K31/421 , A61K45/06 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478
摘要： The invention relates to a compound of formula I, and a preparation method and use thereof. The compound has a bacterial quorum-sensing regulatory effect, and can be used for prevention and/or treatment of a disease caused by a bacterial infection.
摘要翻译： 本发明涉及式I化合物及其制备方法和用途。 该化合物具有细菌感染调节作用，可用于预防和/或治疗由细菌感染引起的疾病。
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公开(公告)号：EP2573067B1
公开(公告)日：2018-10-10
申请号：EP11782849.1
申请日：2011-05-16
发明人： LI, Song , ZHONG, Wu , LIU, Ping , XIAO, Junhai , ZHENG, Zhibing , XIE, Yunde , ZHAO, Guoming , WANG, Xiaokui , WANG, Lili , LI, Xingzhou , ZHOU, Xinbo
IPC分类号： C07C215/62 , C07C217/72 , A61K31/137 , A61P31/06
CPC分类号： C07C217/72 , A61K31/137 , C07C213/00 , C07C215/62
摘要： The present invention relates to aromatic butan-2-ol compounds and preparation methods and uses thereof. Specifically, the present invention relates to the compound of Formula I, or an optical isomer, racemate, diastereomer, pharmaceutically acceptable salt or solvate thereof: wherein each of the substituents have the definitions as given in the specification. The present invention further relates to a pharmaceutical composition containing the compound, and the use of the compound in manufacture of a medicament for the treatment and/or prophylaxis of a disease or disorder caused by tubercle bacillus infection. The compound of Formula I of the present invention has advantages in treatment and/or prophylaxis of a disease or disorder caused by tubercle bacillus infection.
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公开(公告)号：EP2805947B1
公开(公告)日：2017-02-22
申请号：EP13738361.8
申请日：2013-01-15
申请人： Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China , Peking University
发明人： LI, Song , WANG, Ying , XIAO, Junhai , MA, Dalong , GONG, Hongwei , QI, Hui , WANG, Lili , LING, Xiaomei , ZHENG, Zhibing , ZHANG, Yang , ZHONG, Wu , LI, Meina , XIE, Yunde , XU, Enquan , LI, Xingzhou , MA, Jing , ZHAO, Guoming , ZHOU, Xinbo , WANG, Xiaokui , LIU, Hongying
IPC分类号： C07D403/14 , A61K31/506 , A61K31/519 , A61P11/06 , A61P17/00 , C07D403/12 , C07D239/50 , C07D417/12 , A61P29/00 , A61P37/00
CPC分类号： C07D471/04 , C07D239/50 , C07D401/12 , C07D403/12 , C07D403/14 , C07D417/12
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8.发明授权THIAZOLAMINE DERIVATIVE AND USE THEREOF AS ANTI-PICORNAVIRAL INFECTION MEDICAMENT 有权THIAZOLAMINDERIVAT及其作为药物的用途反对小核糖核酸病毒感染
公开(公告)号：EP2650292B1
公开(公告)日：2015-08-26
申请号：EP11847007.9
申请日：2011-12-06
发明人： LI, Song , WANG, Hongliang , XIAO, Junhai , ZHANG, Xian , WANG, Lili , ZHENG, Zhibing , ZHONG, Wu , XIE, Yunde , LI, Xingzhou , ZHOU, Xinbo , ZHAO, Guoming , WANG, Xiaokui
IPC分类号： C07D417/04 , A61K31/496 , A61P31/14 , A61P31/16
CPC分类号： C07D417/04 , A61K31/496 , C07D277/42 , Y02A50/465
摘要： Disclosed is as a substituted thiazolamine derivative represented by Formula I or a pharmaceutically acceptable salt thereof or a hydrate thereof (the definitions of each group in the formula are as presented in the description), and the application thereof in the prevention and/or treatment of viral diseases induced by picornavirus. Also disclosed is a pharmaceutical composition containing the compound.
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9.发明授权PYRIDAZINE DERIVATIVES AND USE THEREOF AS MEDICAMENTS FOR TREATING MICRORNA VIRAL INFECTION 有权哒嗪和它们作为药物的微RNA病毒感染的治疗
公开(公告)号：EP2602252B1
公开(公告)日：2016-05-04
申请号：EP11814093.8
申请日：2011-08-02
发明人： LI, Song , WANG, Hongliang , XIAO, Junhai , ZHANG, Xian , WANG, Lili , ZHENG, Zhibing , ZHONG, Wu , XIE, Yunde , LI, Xingzhou , ZHOU, Xinbo , ZHAO, Guoming , WANG, Xiaokui
IPC分类号： C07D401/04 , A61K31/501 , A61P31/16
CPC分类号： C07D237/20
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10.发明公开DERIVATIVE OF HOMOSERINE LACTONE, AND PREPARATION METHOD AND USE THEREOF 审中-公开DERIVAT VON HOMOSERINLACTON SOWIE HERSTELLUNGSVERFAHREN UND VERWENDUNG DAVON
公开(公告)号：EP2955174A1
公开(公告)日：2015-12-16
申请号：EP13874809.0
申请日：2013-12-10
发明人： LI, Song , XIAO, Junhai , ZHAO, Mingming , ZHONG, Wu , WANG, Lili , ZHENG, Zhibing , XIE, Yunde , LI, Xingzhou , ZHAO, Guoming , ZHOU, Xinbo , WANG, Xiaokui , CHEN, Wei
IPC分类号： C07D307/33 , A61K31/635 , A61P31/04
CPC分类号： C07D307/33 , A61K31/365 , A61K45/06 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478
摘要： Disclosed are a derivative of homoserine lactone represented by formula I, and a preparation method and use thereof. The compound has a bacterial quorum-sensing regulatory effect, and can be used for prevention and/or treatment of a disease caused by a bacterial infection.
摘要翻译： 公开了由式I表示的高丝氨酸内酯的衍生物及其制备方法和用途。 该化合物具有细菌感染调节作用，可用于预防和/或治疗由细菌感染引起的疾病。
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