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21.发明公开DISACCHARIN, DIFUMARIC ACID, DI-L-HYDROXY-2-NAPHTHOIC ACID AND MONO-BENZOIC ACID SALTS OF 4- (DIMETHYLAMIN0)BUTYL 2- (4- ( (2-AMINO-4-METHYL-6- (PENTYLAMINO) PYRIMIDIN- 5 -YL) METHYL) PHENYL)ACETATE 有权SACCHARIN-，FUMARSÄURE-，L-羟基-2-萘甲酸酯将4-（二甲基氨基）丁基-2-（4 - （（2-氨基-4-甲基-6-（戊酰氨基）吡咯烷-5-基） 甲基）苯基）ACETATS
公开(公告)号：EP2435412A1
公开(公告)日：2012-04-04
申请号：EP10721194.8
申请日：2010-05-20
IPC分类号： C07D239/49 , A61K31/505 , A61P11/00 , A61P17/00 , A61P27/14 , A61P31/00 , A61P35/00
CPC分类号： C07D239/49 , C07D275/06
摘要： The invention provides salts of 4- (dimethylamino) butyl 2- (4- ( (2-amino-4-methyl-6- (pentylamino) pyrimidin-5-yl ) methyl ) phenyl ) acetate (compound (I)), pharmaceutical compositions containing them and their use in therapy.
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22.发明公开PHARMACEUTICALLY ACCEPTABLE SALTS OF METHYL (3-{ ÝÝ3-(6- AMINO- 2-BUTOXY-8-OXO-7, 8-DIHYDRO-9H-PURIN-9-YL) PROPYL¨(3- MORPHOLIN-4-YLPROPYL) AMINO¨METHYL }PHENYL) ACETATE AND THEIR USE IN THERAPY 审中-公开药学上可接受的甲基盐（3 - {[[3-（6-氨基-2-丁氧基-8-氧代-7,8-二氢-9H-嘌呤-9-基）丙基] -3-（吗啉-4-基 - 丙基 基）氨基]甲基}苯基）乙酸甲酯及其用于治疗的目的
公开(公告)号：EP2235018A1
公开(公告)日：2010-10-06
申请号：EP08862259.2
申请日：2008-12-16
发明人： MCINALLY, Thomas , SCHULZ, Håkan
IPC分类号： C07D473/18 , A61K31/5377 , A61P11/00 , A61P11/06 , A61P17/00 , A61P31/12 , A61P31/18 , A61P35/00 , A61P37/02 , A61P37/08
CPC分类号： C07D473/18
摘要： The present invention concerns hydrochloric acid, hydrobromic acid and maleic acid salts of methyl (3-{ [ [3- (6-amino-2- butoxy-8-oxo-7, 8-dihydro-9H-purin-9-yl) propyl] (3-morpholin-4- ylpropyl) amino] methyl} phenyl) acetate, compositions comprising them and their use in therapy.
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公开(公告)号：EP2155743A1
公开(公告)日：2010-02-24
申请号：EP08737252.0
申请日：2008-05-06
发明人： BONNERT, Roger, Victor , MCINALLY, Thomas , THOM, Stephen , WADA, Hiroki AstraZeneca R&D Charnwood
IPC分类号： C07D471/04 , A61K31/437 , A61P37/02
CPC分类号： C07D471/04
摘要： The present invention provides compounds of formula (I) wherein Ra, R1, R2, R3, X1, Y1, Z1, A, n and m are as defined in the specification, and pharmaceutically acceptable salts thereof, as well as processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
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公开(公告)号：EP1939200A1
公开(公告)日：2008-07-02
申请号：EP06798242.1
申请日：2006-09-22
发明人： MILLICHIP, Ian , MCINALLY, Thomas , BONNERT, Roger
IPC分类号： C07D473/18 , A61K31/522 , A61P11/02 , A61P11/06 , A61P17/00 , A61P27/02 , A61P31/12 , A61P31/18 , A61P35/00 , A61P37/02 , A61P37/08 , A61P43/00 , C07D473/16 , C07D473/24 , C07D473/34
CPC分类号： C07D473/18
摘要： A novel adenine compound represented by the formula (1):
wherein Z represents (un)substituted alkylene, a single bond, etc.; R 1 represents an (un)substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, or heteroaryl group; R 2 represents hydrogen or (un)substituted alkyl; R 3 , R 4 and R 5 each independently represents an (un)substituted alkyl, alkenyl, alkynyl, aryl, or heteroaryl group, provided that R 3 and R 5 may be bonded to each other to form a 3- to 7-membered, saturated carbocycle or heterocycle in cooperation with the adjacent carbon atom; and X represents oxygen, sulfur, SO 2 , NR 6 (R 6 represents hydrogen or alkyl), or a single bond, or a pharmaceutically acceptable salt of the compound. The compound and salt are useful as a medicine.摘要翻译： 由式（1）表示的新型腺嘌呤化合物：其中Z代表（未）取代的亚烷基，单键等; R1代表（未）取代的烷基，烯基，炔基，环烷基，芳基或杂芳基; R2代表氢或（未）取代的烷基; R 3，R 4和R 5各自独立地表示（未）取代的烷基，烯基，炔基，芳基或杂芳基，条件是R 3和R 5可以彼此键合以形成3-至7-元饱和碳环或杂环 与相邻碳原子合作; X代表氧，硫，SO 2，NR 6（R 6代表氢或烷基）或单键，或该化合物的药学上可接受的盐。 该化合物和盐可用作药物。
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公开(公告)号：EP1928876A1
公开(公告)日：2008-06-11
申请号：EP06779380.2
申请日：2006-09-12
发明人： MCINALLY, Thomas , THOM, Stephen , WADA, Hiroki
IPC分类号： C07D473/18 , A61K31/522 , A61P31/12 , A61P35/00 , A61P37/02 , A61P37/08
CPC分类号： C07D473/18
摘要： The present invention provides compounds of formula (I) wherein n, Y, Z, R, R1, R2 and R3 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
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公开(公告)号：EP2651943A1
公开(公告)日：2013-10-23
申请号：EP11805575.5
申请日：2011-12-14
发明人： ABBOTT, Phillip , BONNERT, Roger, Victor , MCINALLY, Thomas , THOM, Stephen , WADA, Hiroki , ONUMA, Satoshi
IPC分类号： C07D473/18 , A61K31/522
CPC分类号： C07D473/18
摘要： The invention provides the compound of formula. (I) and pharmaceutically acceptable salt thereof, pharmaceutical compositions containing the compound and the use of the compound in therapy.
摘要翻译： 本发明提供式（I）化合物及其药学上可接受的盐，含有该化合物的药物组合物和该化合物在治疗中的用途。
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公开(公告)号：EP2121693B1
公开(公告)日：2012-08-08
申请号：EP07848528.1
申请日：2007-12-13
IPC分类号： C07D473/18 , A61K31/495 , A61P11/00 , A61P29/00 , A61P35/00
CPC分类号： C07D473/18
摘要： The present invention provides compounds of formula (I), wherein R1, Y1, X1, Z1, X2, Y2, A, n and R2 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
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28.发明公开PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF ASTHMA, COPD, ALLERGIC RHINITIS, ALLERGIC CONJUNCTIVITIS, ATOPIC DERMATITIS, CANCER, HEPATITIS B, HEPATITIS C, HIV, HPV, BACTERIAL INFECTIONS AND DERMATOSIS 有权嘧啶衍生物用于治疗哮喘，慢性阻塞性肺病，过敏性鼻炎，过敏性结膜炎，特应性皮炎，癌症，乙型肝炎，丙型肝炎，HIV，HPV，细菌感染和治疗皮肤病
公开(公告)号：EP2222648A1
公开(公告)日：2010-09-01
申请号：EP08851708.1
申请日：2008-11-21
IPC分类号： C07D239/48 , A61K31/505 , A61P11/00 , A61P17/00 , A61P27/14 , A61P31/00 , A61P35/00 , C07D239/49 , C07D401/10 , C07D401/12 , C07D403/10 , C07D403/12 , C07D417/10
CPC分类号： C07D239/48 , C07D239/49 , C07D401/10 , C07D401/12 , C07D403/10 , C07D403/12 , C07D417/12
摘要： The present invention provides compounds of formula (I) wherein R 1, R2, R3 and R4 are as defined in the specification, and pharmaceutically acceptable salts thereof, as well as processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
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29.发明公开9-SUBSTITUTED-8-OXO-ADENINE COMPOUNDS AS TOLL-LIKE RECEPTOR (TLR7) MODULATORS 有权9取代-8- OXOADENINVERBINDUNGEN AS Toll样受体（TLR7）调节剂
公开(公告)号：EP2139894A1
公开(公告)日：2010-01-06
申请号：EP08718791.0
申请日：2008-03-19
IPC分类号： C07D473/18 , A61K31/522 , A61P37/00
CPC分类号： C07D473/18
摘要： The present invention provides compounds of formula (I), where n, R1, R2, A, X1, Y1, Z1, X2 and Y2 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
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公开(公告)号：EP2121693A1
公开(公告)日：2009-11-25
申请号：EP07848528.1
申请日：2007-12-13
IPC分类号： C07D473/18 , A61K31/495 , A61P11/00 , A61P29/00 , A61P35/00
CPC分类号： C07D473/18
摘要： The present invention provides compounds of formula (I), wherein R1, Y1, X1, Z1, X2, Y2, A, n and R2 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
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