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公开(公告)号：EP2651937B1
公开(公告)日：2016-05-11
申请号：EP11805574.8
申请日：2011-12-14
发明人： MCINALLY, Thomas , PIMM, Austen
IPC分类号： C07D471/04 , A61K31/4188 , A61K31/4745 , A61P11/06 , A61P17/06 , A61P37/08 , A61P17/04 , A61P17/12 , A61P31/12 , A61P31/18 , A61P31/04 , A61P1/16
CPC分类号： C07D471/04
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2.发明授权PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF ASTHMA, COPD, ALLERGIC RHINITIS, ALLERGIC CONJUNCTIVITIS, ATOPIC DERMATITIS, CANCER, HEPATITIS B, HEPATITIS C, HIV, HPV, BACTERIAL INFECTIONS AND DERMATOSIS 有权嘧啶衍生物用于治疗哮喘，慢性阻塞性肺病，过敏性鼻炎，过敏性结膜炎，特应性皮炎，癌症，乙型肝炎，丙型肝炎，HIV，HPV，细菌感染和治疗皮肤病
公开(公告)号：EP2222648B1
公开(公告)日：2013-01-09
申请号：EP08851708.1
申请日：2008-11-21
IPC分类号： C07D239/48 , A61K31/505 , A61P11/00 , A61P17/00 , A61P27/14 , A61P31/00 , A61P35/00 , C07D239/49 , C07D401/10 , C07D401/12 , C07D403/10 , C07D403/12 , C07D417/10
CPC分类号： C07D239/48 , C07D239/49 , C07D401/10 , C07D401/12 , C07D403/10 , C07D403/12 , C07D417/12
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3.发明授权9-SUBSTITUTED-8-OXO-ADENINE COMPOUNDS AS TOLL-LIKE RECEPTOR (TLR7) MODULATORS 有权作为TOLL样受体（TLR7）调节剂的9-取代-8-氧杂 - 腺嘌呤化合物
公开(公告)号：EP2139894B1
公开(公告)日：2011-10-26
申请号：EP08718791.0
申请日：2008-03-19
IPC分类号： C07D473/18 , A61K31/522 , A61P37/00
CPC分类号： C07D473/18
摘要： The present invention provides compounds of formula (I), where n, R1, R2, A, X1, Y1, Z1, X2 and Y2 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译： 本发明提供了式（I）化合物，其中n，R 1，R 2，A，X 1，Y 1，Z 1，X 2和Y 2如说明书中所定义，其制备方法，含有它们的药物组合物及其在治疗中的用途 。
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4.发明公开9-SUBSTITUTED-8-OXO-ADENINE COMPOUNDS AS TOLL-LIKE RECEPTOR (TLR7 ) MODULATORS 有权作为TOLL样受体（TLR7）调节剂的9-取代-8-氧杂 - 腺嘌呤化合物
公开(公告)号：EP2132209A1
公开(公告)日：2009-12-16
申请号：EP08718797.7
申请日：2008-03-19
IPC分类号： C07D473/18 , A61K31/522 , A61P37/00
CPC分类号： C07D473/18
摘要： The present invention provides compounds of formula (I): wherein R1, Y1, X1, L and R2 are as defined in the specification, and pharmaceutically acceptable salts thereof, as well as processes for their preparation, pharmaceutical compositions containing them and their use as modulation of toll-like receptor (especially TLR7).
摘要翻译： 本发明提供了式（I）化合物：其中R 1，Y 1，X 1，L和R 2如说明书中所定义，及其药学上可接受的盐，及其制备方法，含有它们的药物组合物及其作为 调节toll样受体（特别是TLR7）。
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5.发明授权9-SUBSTITUTED-8-OXO-ADENINE COMPOUNDS AS TOLL-LIKE RECEPTOR (TLR7 ) MODULATORS 有权9取代-8- OXOADENINVERBINDUNGEN Toll样受体的调节剂（TLR7）
公开(公告)号：EP2132209B8
公开(公告)日：2014-04-16
申请号：EP08718797.7
申请日：2008-03-19
IPC分类号： C07D473/18 , A61K31/522 , A61P37/00
CPC分类号： C07D473/18
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6.发明授权9-SUBSTITUTED-8-OXO-ADENINE COMPOUNDS AS TOLL-LIKE RECEPTOR (TLR7 ) MODULATORS 有权作为TOLL样受体（TLR7）调节剂的9-取代-8-氧杂 - 腺嘌呤化合物
公开(公告)号：EP2132209B1
公开(公告)日：2014-02-12
申请号：EP08718797.7
申请日：2008-03-19
IPC分类号： C07D473/18 , A61K31/522 , A61P37/00
CPC分类号： C07D473/18
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公开(公告)号：EP2651937A1
公开(公告)日：2013-10-23
申请号：EP11805574.8
申请日：2011-12-14
发明人： MCINALLY, Thomas , PIMM, Austen
IPC分类号： C07D471/04 , A61K31/4188 , A61K31/4745 , A61P11/06 , A61P17/06 , A61P37/08 , A61P17/04 , A61P17/12 , A61P31/12 , A61P31/18 , A61P31/04 , A61P1/16
CPC分类号： C07D471/04
摘要： The invention provides the compound of formula (I) and pharmaceutically acceptable salt thereof, pharmaceutical compositions containing the compound and the use of the compound in therapy.
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8.发明公开NOVEL PYRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER AND FURTHER DISEASES 有权新的嘧啶衍生物及其用途是治疗癌症和其他疾病的治疗
公开(公告)号：EP2432768A1
公开(公告)日：2012-03-28
申请号：EP10721195.5
申请日：2010-05-20
IPC分类号： C07D239/49 , C07D401/12 , C07D403/12 , C07D413/12 , A61K31/505 , A61K31/5377 , A61P35/00
CPC分类号： C07D413/12 , C07D239/48 , C07D239/49
摘要： The invention concerns compounds of Formula (I): wherein L
1 , R
1 , R
2 , R
3 , R
4 and X are as defined in the description. The present invention also relates to processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the treatment of disease, for example cancer.-
公开(公告)号：EP1939198A1
公开(公告)日：2008-07-02
申请号：EP06798198.5
申请日：2006-09-21
发明人： HASHIMOTO, Kazuki , NAKAMURA, Tomoaki , NAKAMURA, Kei , KURIMOTO, Ayumu , ISOBE, Yoshiaki , OGITA, Haruhisa , MILLICHIP, Ian , MCINALLY, Thomas , BONNERT, Roger
IPC分类号： C07D473/18 , A61K31/522 , A61K31/5377 , A61P11/02 , A61P11/06 , A61P17/00 , A61P27/02 , A61P31/12 , A61P31/18 , A61P35/00 , A61P37/02 , A61P37/08 , A61P43/00 , C07D473/16 , C07D473/24 , C07D473/34
CPC分类号： C07D473/18
摘要： An adenine compound or its pharmaceutically acceptable salt as a medicament as shown following formula (1):
wherein R 1 is optionally substituted alkyl group, etc., X is oxygen atom, etc., A is 4 to 8 membered optionally substituted saturated or unsaturated heterocyclic group containing 1 to 2 hetero atoms selected from 1 to 3 nitrogen atoms, 0 to 1 oxygen atom and 0 to 1 sulfur atom, L 1 and L 2 are independently straight or branched chain alkylene, or a single bond, R 2 is optionally substituted alkyl group, etc.摘要翻译： 一种腺嘌呤化合物或其药学上可接受的盐，如下式（1）所示：其中R1为任选取代的烷基等，X为氧原子等，A为4至8元任选取代的饱和或不饱和杂环 含有1至2个选自1至3个氮原子，0至1个氧原子和0至1个硫原子的杂原子的基团，L 1和L 2独立地为直链或支链亚烷基或单键，R 2为任选取代的烷基， 等等
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公开(公告)号：EP2155743B1
公开(公告)日：2012-08-29
申请号：EP08737252.0
申请日：2008-05-06
IPC分类号： C07D471/04 , A61K31/437 , A61P37/02
CPC分类号： C07D471/04
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