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7 条记录 (耗时 0.013 秒)

    NOVEL ADENINE COMPOUND
    1.
    发明公开
    NOVEL ADENINE COMPOUND 审中-公开
    新的腺嘌呤化合物

    公开(公告)号：EP1939199A1

    公开(公告)日：2008-07-02

    申请号：EP06798200.9

    申请日：2006-09-21

    申请人： Dainippon Sumitomo Pharma Co., Ltd. ,  AstraZeneca AB

    发明人： HASHIMOTO, Kazuki ,  NAKAMURA, Tomoaki ,  NAKAMURA, Kei ,  TOJO, Shingo ,  KURIMOTO, Ayumu ,  ISOBE, Yoshiaki ,  WADA, Hiroki ,  BONNERT, Roger

    IPC分类号： C07D473/18 ,  A61K31/522 ,  A61P11/02 ,  A61P11/06 ,  A61P17/00 ,  A61P27/02 ,  A61P31/12 ,  A61P31/18 ,  A61P35/00 ,  A61P37/02 ,  A61P37/08 ,  A61P43/00

    CPC分类号： C07D473/18

    摘要： An adenine compound useful as a medicine represented by the following formula (1):

    [wherein R 1 is halogen atom, optionally substituted alkyl group, optionally substituted aryl group, etc.;
    X is oxygen atom, sulfur atom, a single bond, etc.;
    A 1 is optionally substituted and optionally saturated 4 to 8 membered
    heterocyclic group containing 1 to 2 hetero atoms selected from 1 to 3 nitrogen atoms, 0 to 1 oxygen atom, and 0 to 1 sulfur atom;
    A 2 is optionally substituted 6 to 10 cyclic aromatic hydrocarbon group or optionally substituted 5 to 10 membered heterocyclic aromatic group;
    L 1 and L 2 are independently, substituted straight or branched alkylene or a single bond, etc.;
    L 3 is optionally substituted straight or branched alkylene, etc.;
    R 2 is hydrogen atom, optionally substituted alkyl group.]
    or its pharmaceutically acceptable salt.

    摘要翻译： 一种腺嘌呤化合物，用作由下式（1）表示的药物：[其中R1是卤素原子，任选取代的烷基，任选取代的芳基等; X是氧原子，硫原子，单键等; A1是含有1至2个选自1至3个氮原子，0至1个氧原子和0至1个硫原子的杂原子的任选取代的和任选饱和的4至8元杂环基团; A2任选被取代的6至10个环状芳族烃基或任选取代的5至10元杂环芳基; L 1和L 2独立地为取代的直链或支链亚烷基或单键等; L3是任选取代的直链或支链亚烷基等; R2是氢原子，任选取代的烷基。]或其药学上可接受的盐。

    PYRAZINE DERIVATIVES
    7.
    发明公开
    PYRAZINE DERIVATIVES 审中-公开
    吡嗪

    公开(公告)号：EP2526097A1

    公开(公告)日：2012-11-28

    申请号：EP11701554.5

    申请日：2011-01-18

    申请人： AstraZeneca AB

    发明人： FENG, Tao ,  SANGANEE, Hitesh, Jayantilal ,  WADA, Hiroki

    IPC分类号： C07D401/12 ,  A61K31/397 ,  A61P25/00 ,  A61P3/10

    CPC分类号： C07D401/12

    摘要： The invention concerns pyrazine derivatives of the Formula (I) or pharmaceutically-acceptable salts thereof; wherein each of n, m and R has any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the treatment of bone-related disorders or conditions.