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公开(公告)号：EP0635055A1
公开(公告)日：1995-01-25
申请号：EP93907710.0
申请日：1993-04-05
发明人： POTTER, Andrew, A. , PONTAROLLO, Reno, A. , PFEIFFER, Cheryl, G. , THEISEN, Michael , HARLAND, Richard, J. , RIOUX, Clement
CPC分类号： C07K14/285 , A61K39/00 , C07K2319/40 , C07K2319/55
摘要： Novel Haemophilus somnus immunogenic proteins are disclosed. The proteins can be used in vaccine compositions for the prevention and treatment of H. somnus infections. The proteins are conveniently produced using recombinant technology.
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22.发明授权
公开(公告)号：EP1159426B1
公开(公告)日：2005-12-21
申请号：EP00908866.7
申请日：2000-03-10
IPC分类号： C12N15/31 , C07K14/285 , A61K39/102 , G01N33/68
CPC分类号： C07K14/285 , A61K39/00
摘要： Cloning and expression of genes encoding H. somnus transferring-binding proteins are described. The transferrin-binding proteins can be used in vaccine compositions for the prevention and treatment of H. somnus infections, as well as in diagnostic methods for determining the presence of H. Somnus infections.
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23.发明授权ACTINOBACILLUS PLEUROPNEUMONIAE OUTER MEMBRANE LIPOPROTEIN A AND USES THEREOF 失效胸膜肺炎放线杆菌及其使用脂蛋白外膜
公开(公告)号：EP0669984B1
公开(公告)日：2003-12-17
申请号：EP93923430.8
申请日：1993-11-03
发明人： GERLACH, Gerald F., Institut für Mikrobiologie und , WILLSON, Philip, J. , ROSSI-CAMPOS, Amalia , POTTER, Andrew, A.
IPC分类号： C12N15/31 , C07K14/285 , A61K39/102
CPC分类号： C07K14/285 , A61K39/00 , Y10S424/825 , Y10S435/851
摘要： Novel vaccines for use against Actinobacillus pleuropneumoniae are disclosed. The vaccines contain at least one Actinobacillus pleuropneumoniae outer membrane lipoprotein A, or an immunogenic fragment thereof. Also disclosed are DNA sequences encoding these proteins, vectors including these sequences and host cells transformed with these vectors. The vaccines can be used to treat or prevent porcine respiratory infections.
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公开(公告)号：EP1349570A1
公开(公告)日：2003-10-08
申请号：EP02726978.6
申请日：2002-01-03
发明人： FINLAY, Brett , POTTER, Andrew, A.
IPC分类号： A61K39/108 , C07K14/245 , C12N1/20 , A61P31/04 , A61K39/39 , C07K1/02 , C07K1/34
CPC分类号： A61K39/0258 , A61K2039/55566 , C07K14/245 , Y02A50/474
摘要： Compositions and methods for stimulating an immune response against a secreted enterohemorragic Escherichia coli (EHEC) antigen are disclosed. The compositions comprise EHEC cell culture supernatants.
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25.发明公开IMMUNIZATION OF DAIRY CATTLE WITH CHIMERIC GAPC PROTEIN AGAINST i STREPTOCOCCUS /i INFECTION 有权从链球菌嵌合GAPC蛋白及其免疫和诊断中使用
公开(公告)号：EP1294771A2
公开(公告)日：2003-03-26
申请号：EP01944803.4
申请日：2001-06-11
IPC分类号： C07K19/00 , C12N15/62 , C12N15/70 , C12N1/21 , A61K39/09 , C07K16/12 , G01N33/569 , A61P31/04 , A61K31/7088 , G01N33/68
CPC分类号： G01N33/56944 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/53 , C07K14/315 , C07K2319/00 , G01N2469/20
摘要： The recombinant production of Gap4, a chimeric GapC plasmin binding protein comprising the entire amino acid sequence of the Streptococcus dysgalactiae GapC protein in addition to unique amino acid sequences from the Streptococcus parauberis and Streptococcus agalactiae GapC proteins, is described. Also described is the use of Gap4 chimeric GapC protein in vaccine compositions to prevent or treat streptococcal infections in general and mastitis in particular.
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公开(公告)号：EP0948528A2
公开(公告)日：1999-10-13
申请号：EP97913041.0
申请日：1997-11-14
CPC分类号： C07K14/315 , A61K39/00
摘要： The bovine lactoferrin (bLF) binding protein of Streptococcus uberis (S. uberis) is described, as well as the gene encoding the bLF (1bp). LF-binding proteins can be used in vaccine compositions for the prevention and treatment of S. uberis infections, particularly mastitis, as well as in diagnostic methods for determining the presence of S. uberis infections. Also disclosed is a regulatory region adjacent to 1bp, termed mga.
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公开(公告)号：EP0920510A1
公开(公告)日：1999-06-09
申请号：EP97935395.0
申请日：1997-08-08
IPC分类号： C12N15 , A61K39 , A61K47 , A61P15 , A61P35 , C07K5 , C07K7 , C07K14 , C07K16 , C07K19 , C12N1 , C12P21 , C12R1
CPC分类号： A61K39/0006 , A61K39/00 , A61K47/62 , A61K47/646 , A61K47/6829 , A61K47/6833 , A61K2039/6037 , C07K5/1008 , C07K5/1019 , C07K5/1021 , C07K5/1024 , C07K7/23 , C07K14/005 , C07K14/285 , C07K14/655 , C07K16/26 , C07K2319/00 , C12N2720/12322
摘要： New immunological carrier systems, DNA encoding the same, and the use of these systems, are disclosed. The carrier systems include chimeric proteins which include a leukotoxin polypeptide fused to one or more selected GnRH multimers which comprise at least one repeating GnRH decapeptide sequence, or at least one repeating unit of a sequence corresponding to at least one epitope of a selected GnRH molecule. Under the invention, the selected GnRH sequences may all be the same, or may correspond to different derivatives, analogues, variants or epitopes of GnRH so long as the GnRH sequences are capable of eliciting an immune response. The leukotoxin functions to increase the immunogenicity of the GnRH multimers fused thereto.
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28.发明公开
公开(公告)号：EP0669984A1
公开(公告)日：1995-09-06
申请号：EP93923430.0
申请日：1993-11-03
发明人： GERLACH, Gerald F., Institut für Mikrobiologie und , WILLSON, Philip, J. , ROSSI-CAMPOS, Amalia , POTTER, Andrew, A.
CPC分类号： C07K14/285 , A61K39/00 , Y10S424/825 , Y10S435/851
摘要： Novel vaccines for use against Actinobacillus pleuropneumoniae are disclosed. The vaccines contain at least one Actinobacillus pleuropneumoniae outer membrane lipoprotein A, or an immunogenic fragment thereof. Also disclosed are DNA sequences encoding these proteins, vectors including these sequences and host cells transformed with these vectors. The vaccines can be used to treat or prevent porcine respiratory infections.
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