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公开(公告)号：EP4225762A1
公开(公告)日：2023-08-16
申请号：EP21801754.9
申请日：2021-10-06
发明人： MCCARTNEY, Jason , ABELA, Alexander Russell , ABRAHAM, Sunny , ANDERSON, Corey Don , ARUMUGAM, Vijayalaksmi , CHAU, Jaclyn , CLEMENS, Jeremy , CLEVELAND, Thomas , DWIGHT, Timothy A. , FRIEMAN, Bryan A. , GROOTENHUIS, Peter , HADIDA RUAH, Sara Sabina , ISHIHARA, Yoshihiro , KRENITSKY, Paul , MILLER, Mark Thomas , PIERRE, Fabrice , SILINA, Alina , ZHOU, Jinglan
IPC分类号： C07D515/04 , A61P43/00 , A61K31/519
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公开(公告)号：EP4225748A1
公开(公告)日：2023-08-16
申请号：EP21806071.3
申请日：2021-10-06
发明人： MCCARTNEY, Jason , ABRAHAM, Sunny , ANDERSON, Corey Don , ARUMUGAM, Vijayalaksmi , CHAU, Jaclyn , CLEVELAND, Thomas , DWIGHT, Timothy A. , FRIEMAN, Bryan A. , GROOTENHUIS, Peter , HADIDA RUAH, Sara Sabina , ISHIHARA, Yoshihiro , MILLER, Mark Thomas , SILINA, Alina , ZHOU, Jinglan
IPC分类号： C07D401/14 , C07D239/69 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/04 , C07D471/04 , C07D491/107 , A61P43/00 , A61K31/506
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公开(公告)号：EP4225447A1
公开(公告)日：2023-08-16
申请号：EP21805707.3
申请日：2021-10-06
发明人： MCCARTNEY, Jason , ABELA, Alexander Russell , ABRAHAM, Sunny , ANDERSON, Corey Don , ARUMUGAM, Vijayalaksmi , CHAU, Jaclyn , CLEMENS, Jeremy , CLEVELAND, Thomas , COON, Timothy Richard , DINH, Andrew , DWIGHT, Timothy A. , FANNING, Lev Tyler Dewey , FRIEMAN, Bryan A. , GROOTENHUIS, Peter , HADIDA RUAH, Sara Sabina , ISHIHARA, Yoshihiro , KRENITSKY, Paul , MILLER, Mark Thomas , PIERRE, Fabrice , SILINA, Alina , TRAN, Joe A. , VALDEZ, Lino , ZHOU, Jinglan
IPC分类号： A61P43/00 , C07D515/04 , A61K31/519
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公开(公告)号：EP3203840B1
公开(公告)日：2020-08-05
申请号：EP15849396.5
申请日：2015-10-06
发明人： MILLER, Mark Thomas , ANDERSON, Corey , ARUMUGAM, Vijayalaksmi , BEAR, Brian Richard , BINCH, Hayley Marie , CLEMENS, Jeremy J. , CLEVELAND, Thomas , CONROY, Erica , COON, Timothy Richard , FRIEMAN, Bryan A. , GROOTENHUIS, Peter Diederik Jan , GROSS, Raymond Stanley , HADIDA-RUAH, Sara Sabina , KHATUYA, Haripada , JOSHI, Pramod Virupax , KRENITSKY, Paul John , LIN, Chun-Chieh , MARELIUS, Gulin Erdogan , MELILLO, Vito , MCCARTNEY, Jason , NICHOLLS, Georgia McGaughey , PIERRE, Fabrice Jean Denis , SILINA, Alina , TERMIN, Andreas P. , UY, Johnny , ZHOU, Jinglan
IPC分类号： A01N41/06 , A61K31/18 , C07D403/12 , C07D413/14 , C07D213/73 , C07D231/20 , C07D401/04 , C07D235/24 , C07D403/10 , C07D239/34 , C07D407/12 , C07D209/18 , C07D209/49 , C07D213/64
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公开(公告)号：EP2560650A1
公开(公告)日：2013-02-27
申请号：EP11718597.5
申请日：2011-04-22
发明人： VAN GOOR, Fredrick, F. , ALARGOVA, Rossitza, Gueorguieva , ALCACIO, Tim, Edward , AREKAR, Sneha, G. , BINCH, Hayley, Marie , BOTFIELD, Martyn, Curtis , FANNING, Lev, Tyler Dewey , GROOTENHUIS, Peter, Diederik Jan , HURLEY, Dennis, James , JOHNSTON, Steven, C. , KADIYALA, Irina, Nikolaevna , KAUSHIK, Ritu, Rohit , KESHAVARZ-SHOKRI, Ali , KRAWIEC, Mariusz , LEE, Elaine, Chungmin , LUISI, Brian , MEDEK, Ales , MUDUNURI, Praveen , NUMA, Mehdi , SHETH, Urvi Jagdishbhai , SILINA, Alina , SULLIVAN, Mark Jeffrey , VERWIJS, Marinus Jacobus , YANG, Xiaoqing , YOUNG, Christopher Ryan , ZAMAN, Noreen Tasneem , ZHANG, Beili , ZHANG, Yuegang , ZLOKARNIK, Gregor
IPC分类号： A61K31/4704 , A61K31/404 , A61K31/443
CPC分类号： A61K31/4709 , A61K31/404 , A61K31/443 , A61K31/4433 , A61K31/47 , A61K31/4704 , G01N33/6872 , G01N2333/4703 , A61K2300/00
摘要： The present invention relates to pharmaceutical compositions comprising a compound of Formulas I and II, optionally in combination with a Compound of Formula III and/or a Compound of Formula IV. The invention also relates to solid forms and to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis.
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公开(公告)号：EP2349263A2
公开(公告)日：2011-08-03
申请号：EP09822784.6
申请日：2009-10-23
发明人： BINCH, Hayley , FANNING, Lev, T., D. , HURLEY, Dennis , SHETH, Urvi , SILINA, Alina , YANG, Xiaoqing , BOTFIELD, Martyn , GROOTENHUIS, Peter, D.J. , VAN GOOR, Fredrick , NUMA, Mehdi, Michel Djamel
IPC分类号： A61K31/439 , C07D453/04 , C12Q1/02
CPC分类号： A61K31/4709 , A61K45/06 , C07D215/56 , C07D221/22 , C07D451/02 , C07D471/06 , C07D471/08 , C07D487/04 , C07D487/08 , C07F7/1856 , G01N33/5041 , G01N33/6872 , G01N2800/382
摘要： The present invention relates to modulators of cystic fibrosis transmembrane conductance regulator ("CFTR"), compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using modulators of CFTR. (l); or pharmaceutically acceptable salts thereof, wherein: ring A is selected from:
摘要翻译： 本发明涉及囊性纤维化跨膜传导调节剂（“CFTR”）的调节剂，其组合物及其方法。 本发明还涉及使用CFTR调节剂治疗疾病的方法。 （升）; 或其药学上可接受的盐，其中：环A选自：
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公开(公告)号：EP1817032A2
公开(公告)日：2007-08-15
申请号：EP05852296.2
申请日：2005-11-29
发明人： HURLEY, Dennis, J. , BERGERON, Daniele, M. , DRUTU, Ioana , GARCIA-GUZMAN BLANCO, Miguel , MAKINGS, Lewis, R. , NAKATANI, Akiko , RAFFAI, Gabriel , SILINA, Alina
IPC分类号： A61K31/4439 , A61K31/454 , A61P25/18
CPC分类号： C07D211/10 , A61K31/4439 , C07D211/18 , C07D211/32 , C07D211/34 , C07D211/38 , C07D211/42 , C07D211/52 , C07D211/64 , C07D401/04 , C07D401/06 , C07D401/10 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/10 , C07D417/10 , C07D417/12 , C07D451/02 , C07D493/08
摘要： The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
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公开(公告)号：EP1781288A2
公开(公告)日：2007-05-09
申请号：EP05792897.0
申请日：2005-08-19
发明人： MAKINGS, Lewis, R. , GARCIA-GUZMAN BLANCO, Miguel , HURLEY, Dennis, J. , DRUTU, Ioana , RAFFAI, Gabriel , BERGERON, Daniele, M. , NAKATANI, Akiko , TERMIN, Andreas, P. , SILINA, Alina
IPC分类号： A61K31/435 , A61K31/438 , A61P43/00 , A61P25/00 , C07D471/00
CPC分类号： C07D401/06 , A61K31/435 , A61K31/438 , A61K31/4747 , A61K31/55 , C07D221/20 , C07D223/32 , C07D405/04 , C07D405/06 , C07D405/12 , C07D451/02 , C07D451/04 , C07D471/10 , C07D491/10
摘要： The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
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