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    OPTICALLY ACTIVE FORM OF MEPENZOLATE, AND AMELIORATING AGENT FOR CHRONIC OBSTRUCTIVE PULMONARY DISEASE WHICH CONTAINS SAME AS ACTIVE INGREDIENT
    4.
    发明公开
    OPTICALLY ACTIVE FORM OF MEPENZOLATE, AND AMELIORATING AGENT FOR CHRONIC OBSTRUCTIVE PULMONARY DISEASE WHICH CONTAINS SAME AS ACTIVE INGREDIENT 审中-公开
    OPTISCH AKTIVE FORM VON MEPENZOLAT UND LINDERUNGSMITTELFÜRCHRONISCH-OBSTRUKTIVE LUNGENERKRANKUNG DAMIT ALS WIRKSTOFF

    公开(公告)号：EP3109232A4

    公开(公告)日：2017-06-28

    申请号：EP14882606

    申请日：2014-06-16

    申请人： LTT BIO-PHARMA CO LTD

    发明人： MIZUSHIMA TORU

    IPC分类号： C07D211/42 ,  A61K31/452 ,  A61P11/00 ,  A61P11/08 ,  A61P29/00

    CPC分类号： C07D211/42 ,  A61K31/452

    摘要： An optically active form of mepenzolate bromide is provided. An agent for ameliorating chronic obstructive pulmonary disease that contains the optically active form as an active ingredient and is based on a bronchodilator effect and an anti-inflammatory effect is also provided. (3R)- or (3S)-3-[(hydroxy)(diphenyl)acetoxy]-1,1-dimethylpiperidinium bromide (hereinafter referred to as "(R)- or (S)-mepenzolate bromide") is provided. An agent for ameliorating chronic obstructive pulmonary disease that contains the (R)- or (S)-mepenzolate bromide as an active ingredient is provided. Furthermore, an agent for ameliorating chronic obstructive pulmonary disease whose mode of administration is airway administration or inhalation administration is provided.

    摘要翻译： 提供了一种光学活性形式的甲苯溴化物。 还提供了一种用于改善慢性阻塞性肺病的药剂，其含有光学活性形式作为活性成分并基于支气管扩张作用和抗炎作用。 （3R） - 或（3S）-3 - [（羟基）（二苯基）乙酰氧基] -1,1-二甲基哌啶鎓溴化物（以下称为“（R） - 或（S） 本发明提供了含有（R） - 或（S） - 溴苯佐辛溴化物作为活性成分的缓解慢性阻塞性肺病的药剂。 此外，提供了一种改善慢性阻塞性肺病的药物，其给药方式为气道给药或吸入给药。

    CYCLIC AMINE COMPOUND
    10.
    发明授权
    CYCLIC AMINE COMPOUND 有权
    环胺类化合物

    公开(公告)号：EP1911743B1

    公开(公告)日：2012-04-04

    申请号：EP06782403.7

    申请日：2006-08-01

    申请人： Takeda Pharmaceutical Company Limited

    发明人： YAMAMOTO, Satoshi TAKEDA PHARMACEUTICAL CO., LTD. ,  HASUOKA, Atsushi TAKEDA PHARMACEUTICAL CO., LTD.

    IPC分类号： C07D207/08 ,  A61K31/402 ,  A61K31/451 ,  A61K31/47 ,  A61P5/26 ,  A61P7/00 ,  A61P7/06 ,  A61P9/10 ,  A61P15/10 ,  A61P15/12 ,  A61P19/10 ,  A61P25/24 ,  A61P25/28 ,  A61P35/00 ,  C07D207/12 ,  C07D211/42 ,  C07D215/06

    CPC分类号： C07D207/08 ,  C07D207/12 ,  C07D211/42 ,  C07D215/06

    摘要： A compound represented by the formula (I) or a salt thereof: (I) wherein the ring A represents a 5- to 8-membered ring which may have additional substituent besides R6, R7 and R8; R1 represents an electron-attracting group; R2, R3, R4 and R5 independently represent a hydrogen atom, a halogen atom, a group attached through a carbon atom, a group attached through a nitrogen atom, a group attached through an oxygen group, or a group attached through a sulfur atom; R6 represents a halogen atom, a group attached through a carbon atom, a group attached through a nitrogen atom, a group attached through an oxygen group, or a group attached through a sulfur atom, and R7 represents a cyano group, a nitro group, an acyl group which may have a substituent, a carboxyl group which may be esterified or amidated, or a hydrocarbon group which may have a substituent, or R6 and R7 together with a carbon atom to which they are attached may form a ring which may have a substituent; and R8 represents a hydrogen atom, a halogen atom, a group attached through a carbon atom, a group attached through an oxygen atom, or a group attached through a sulfur atom. The compound or salt has an excellent androgen receptor modulating effect, and is useful for the prevention/treatment of hypogonadism, partial androgen deficiency in aging male, decline in physical strength, cachexia, osteoporosis and the like.

    摘要翻译： 由式（I）表示的化合物或其盐：（I）其中环A表示除R6，R7和R8以外可以具有另外的取代基的5至8元环; R1表示吸电子基团; R 2，R 3，R 4和R 5独立地表示氢原子，卤原子，通过碳原子连接的基团，通过氮原子连接的基团，通过氧基连接的基团或通过硫原子连接的基团; R6表示卤原子，通过碳原子连接的基团，通过氮原子连接的基团，通过氧基连接的基团或通过硫原子连接的基团，并且R7表示氰基，硝基， 可以具有取代基的酰基，可以被酯化或酰胺化的羧基或可以具有取代基的烃基，或者R6和R7与它们所连接的碳原子一起可以形成可以具有取代基的环 取代基; 并且R 8表示氢原子，卤素原子，通过碳原子连接的基团，通过氧原子连接的基团或通过硫原子连接的基团。 该化合物或盐具有优异的雄激素受体调节作用，可用于预防/治疗性腺机能减退症，老化雄性部分雄激素缺乏症，体力下降，恶病质，骨质疏松症等。