公开(公告)号：EP3619320B1

公开(公告)日：2024-09-11

申请号：EP18719616.7

申请日：2018-05-02

IPC分类号： C12Q1/6883

CPC分类号： C12Q1/6883 ,  C12Q2600/17820130101

公开(公告)号：EP4421189A1

公开(公告)日：2024-08-28

申请号：EP23382178.4

申请日：2023-02-27

申请人： Universitat de Barcelona ,  Consorcio Centro de Investigación Biomédica en Red ,  Fundació Institut de recerca de l'Hospital de la Santa Creu i Sant Pau

发明人： MARTI PUIG, Eulalia ,  GÁMEZ VALERO, Ana ,  HERRERO LORENZO, Marina ,  ESCARAMIS BABIANO, Georgia ,  KULISEVSKY BOJARSKI, Jaime ,  PÉREZ PÉREZ, Jesús ,  MARTÍNEZ HORTA, Saül, Indra

IPC分类号： C12Q1/6883

CPC分类号： C12Q1/6883 ,  C12Q2600/17820130101

摘要： The present invention refers to an in vitro method for the diagnosis or prognosis of Huntington's disease, preferably for the early diagnosis or prognosis of Huntington's disease. Said method involves assessing the level of expression of a tRNA fragment that comprises the 5'end of tRNAGlu/CTC (tRF-5Glu/CTC ) or 5'end of tRNAGly/GCC (tRF-5Gly/GCC ) in a biological sample obtained from the subject, wherein the identification of a deviation in the expression level with respect to a pre-established threshold value determined in healthy subjects is an indication that the subject may be suffering from Huntington's disease or has a poor prognosis.

公开(公告)号：EP4372102A3

公开(公告)日：2024-08-14

申请号：EP24154866.8

申请日：2017-06-06

申请人： RedVault Biosciences, LP

发明人： METZKER, Michael, L. ,  WEIER, Christopher August

IPC分类号： C12Q1/68 ,  C12Q1/70 ,  C12Q1/6876 ,  C12Q1/6844

CPC分类号： C12Q1/6844 ,  C12Q1/703 ,  C12Q2600/17820130101 ,  C12Q1/6876

摘要： Provided herein are methods and compositions for the detection of target nucleic acids using target reporter constructs (TRCs) which comprise target sequences complementary to the target nucleic acid. Further provided are methods of replicating the TRCs using rolling circle replication and/or rolling circle amplification to produce replicated TRCs which can be detected using probe sequences within the replicated TRCs.

公开(公告)号：EP4328587A3

公开(公告)日：2024-06-05

申请号：EP23216032.5

申请日：2019-02-12

申请人： Toray Industries, Inc. ,  National Center for Geriatrics and Gerontology

发明人： SUZUKI, Kana ,  YOSHIMOTO, Makiko ,  KAWAUCHI, Junpei ,  SUDO, Hiroko ,  KIDA, Yuho ,  KOZONO, Satoko ,  KONDOU, Satoshi ,  NIIDA, Shumpei ,  ASANOMI, Yuya ,  SHIGEMIZU, Daichi ,  SAKURAI, Takashi

IPC分类号： C12Q1/6883 ,  C12N15/09 ,  C12M1/34 ,  G01N33/53

CPC分类号： C12Q1/6883 ,  C12Q2600/15820130101 ,  C12Q2600/17820130101

摘要： An embodiment according to the present invention provides a kit or device for detection of dementia, and a method for detecting dementia. An embodiment according to the present invention relates to: a kit or device for detection of dementia, including a nucleic acid(s) capable of specifically binding to an miRNA(s) or a complementary strand(s) thereof in a sample from a subject; and a method for detecting dementia, including measuring the miRNA(s) in vitro.

公开(公告)号：EP4367257A2

公开(公告)日：2024-05-15

申请号：EP22838508.4

申请日：2022-07-09

申请人： Dana-Farber Cancer Institute, Inc. ,  Medical University of Lodz

发明人： CHOWDHURY, Dipanjan ,  FENDLER, Wojciech ,  STAWISKI, Konrad

IPC分类号： C12Q1/68 ,  C12Q1/6886 ,  G16B40/00

CPC分类号： C12Q1/6886 ,  C12Q2600/17820130101 ,  C12Q2600/15820130101

公开(公告)号：EP4365304A1

公开(公告)日：2024-05-08

申请号：EP22383065.4

申请日：2022-11-07

申请人： Universidad Autónoma de Madrid

发明人： Sánchez Pacheco, Aurora ,  López López, Ana ,  Camblor Murube, Marina

IPC分类号： C12Q1/6853 ,  C12Q1/6876

CPC分类号： C12Q1/6853 ,  C12Q1/6876 ,  C12Q2600/17820130101

摘要： The invention relates to a novel stem-loop primer comprising the nucleotide sequence SEQ ID NO: 1 which presents a short length RNA target-specific region and the composition or the kit comprising the stem-loop. Further, the invention also relates to a method for short length RNA detection, particularly miRNA detection, based on the combination of the novel stem-loop and a miRNA-specific forward primer with a universal reverse primer and universal probe in a reverse-transcription quantitative PCR (RT-qPCR).

公开(公告)号：EP3600472B1

公开(公告)日：2024-04-17

申请号：EP18771563.6

申请日：2018-03-23

IPC分类号： C12Q1/6883

CPC分类号： A61B10/0051 ,  A61B5/4064 ,  C12Q1/6883 ,  C12Q2600/17820130101

公开(公告)号：EP4431619A3

公开(公告)日：2024-10-02

申请号：EP23213429.6

申请日：2023-11-30

申请人： Kabushiki Kaisha Toshiba

发明人： ANDO, Tomomi ,  ISHIHARA, Mitsuko ,  SANO, Yoshitake

IPC分类号： C12Q1/6886

CPC分类号： C12Q1/6886 ,  C12Q2600/17820130101 ,  C12Q2600/15620130101

摘要： According to one arrangement, method of identifying feature of test body is provided. The method includes, measuring a mutation-specific concentration of at least one miRNA contained in the test body, correcting a value of the mutation-specific concentration, and determining whether the test body is a cancer or a non-cancer one using an increase or decrease in the corrected mutation-specific concentration as index.

公开(公告)号：EP4431619A2

公开(公告)日：2024-09-18

申请号：EP23213429.6

申请日：2023-11-30

申请人： Kabushiki Kaisha Toshiba

发明人： ANDO, Tomomi ,  ISHIHARA, Mitsuko ,  SANO, Yoshitake

IPC分类号： C12Q1/6886

CPC分类号： C12Q1/6886 ,  C12Q2600/17820130101 ,  C12Q2600/15620130101

摘要： According to one arrangement, method of identifying feature of test body is provided. The method includes, measuring a mutation-specific concentration of at least one miRNA contained in the test body, correcting a value of the mutation-specific concentration, and determining whether the test body is a cancer or a non-cancer one using an increase or decrease in the corrected mutation-specific concentration as index.

公开(公告)号：EP4114977B1

公开(公告)日：2024-09-11

申请号：EP21723451.7

申请日：2021-03-01

IPC分类号： C12Q1/6883

CPC分类号： C12Q1/6883 ,  C12Q2600/15820130101 ,  C12Q2600/17820130101