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21.发明公开COMPOSITIONS, METHODS, AND DEVICES FOR DIALYSIS 审中-公开DIALYSEZUSAMMENSETZUNGEN，-VERFAHREN UND -VORRICHTUNGEN
公开(公告)号：EP3003358A4
公开(公告)日：2017-03-22
申请号：EP14807765
申请日：2014-06-06
CPC分类号： A61M1/287 , A01K67/00 , A01K2207/20 , A01K2227/108 , A01K2267/03 , A61K38/43 , A61K38/44 , A61K38/45 , A61K38/50 , A61K38/51 , C12Y101/00 , C12Y103/03005 , C12Y114/16001 , C12Y305/01005 , C12Y401/01002 , C12Y403/01024
摘要： Compositions of peritoneal dialysis solutions and metabolizing enzymes, and their uses to treat disorders associated with elevated levels of metabolites are disclosed. Animal models of hyperoxalemia are also disclosed.
摘要翻译： 公开了腹膜透析溶液和代谢酶的组合物及其用于治疗与代谢物水平升高相关的疾病的用途。 还公开了高氧血症的动物模型。
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公开(公告)号：EP2281079B1
公开(公告)日：2015-04-01
申请号：EP09713280.7
申请日：2009-02-12
CPC分类号： C12N11/04 , A61K9/0092 , A61K38/44 , B82Y30/00 , C02F3/102 , C02F3/34 , C02F3/342 , C02F2101/18 , C02F2101/20 , C02F2101/306 , C02F2101/36 , C02F2305/08 , C09D167/04 , C09D171/02 , C12M21/18 , C12M23/06 , C12M23/16 , C12Q1/66 , C12Y113/12007 , C12Y114/16001 , D01D5/003 , D01D5/247 , D01F1/10 , D01F8/14 , G01N33/54393 , G01N2333/90241 , Y02W10/15 , Y10T428/1393
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公开(公告)号：EP2170314B1
公开(公告)日：2013-10-02
申请号：EP08754714.7
申请日：2008-05-23
发明人： MATALON, Reuben
IPC分类号： A61K31/195 , C12N9/00
CPC分类号： C12N9/0071 , A61K38/00 , A61K38/48 , C12N9/88 , C12Y114/16001 , C12Y403/01024 , A61K2300/00
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24.发明公开
公开(公告)号：EP2281079A2
公开(公告)日：2011-02-09
申请号：EP09713280.7
申请日：2009-02-12
CPC分类号： C12N11/04 , A61K9/0092 , A61K38/44 , B82Y30/00 , C02F3/102 , C02F3/34 , C02F3/342 , C02F2101/18 , C02F2101/20 , C02F2101/306 , C02F2101/36 , C02F2305/08 , C09D167/04 , C09D171/02 , C12M21/18 , C12M23/06 , C12M23/16 , C12Q1/66 , C12Y113/12007 , C12Y114/16001 , D01D5/003 , D01D5/247 , D01F1/10 , D01F8/14 , G01N33/54393 , G01N2333/90241 , Y02W10/15 , Y10T428/1393
摘要： A method of attaching a cell or a membrane-coated particle-of-interest to a microtube is provided. The method comprising: co-electrospinning two polymeric solutions through co-axial capillaries, wherein a first polymeric solution of the two polymeric solutions is for forming a shell of the microtube and a second polymeric solution of the two polymeric solutions is for forming a coat over an internal surface of the shell, the first polymeric solution is selected solidifying faster than the second polymeric solution and a solvent of the second polymeric solution is selected incapable of dissolving the first polymeric solution and wherein the second polymeric solution comprises the cell or the membrane-coated particle-of-interest, thereby attaching the cell or the membrane-coated particle-of-interest to the microtube. Also provided are microtubes with attached, entrapped or encapsulated cells or membrane-coated particles and methods of using same.
摘要翻译： 提供将细胞或膜包被的感兴趣颗粒附着到微管的方法。 该方法包括：通过同轴毛细管共同静电纺两种聚合物溶液，其中两种聚合物溶液的第一聚合溶液用于形成微管的壳，并且两种聚合物溶液的第二聚合溶液用于形成涂层 所述壳的内表面选择所述第一聚合物溶液比所述第二聚合物溶液凝固更快，并且所述第二聚合物溶液的溶剂被选择为不能溶解所述第一聚合物溶液，并且其中所述第二聚合物溶液包含所述电池或所述膜 - 涂覆感兴趣的颗粒，从而将感兴趣的细胞或膜包被的穗结合在微管上。 还提供了具有附着，包埋或包封的细胞或膜包衣颗粒的微管及其使用方法。
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公开(公告)号：EP2265751A2
公开(公告)日：2010-12-29
申请号：EP09713264.1
申请日：2009-02-12
IPC分类号： D01D5/24 , D01F8/14 , D01F1/10 , A61M1/34 , B01J19/00 , B01L3/00 , C02F1/58 , G01N33/53 , C02F3/00 , A61K9/00 , B01D69/08
CPC分类号： C12N11/04 , A61K9/0092 , A61K38/44 , B82Y30/00 , C02F3/102 , C02F3/34 , C02F3/342 , C02F2101/18 , C02F2101/20 , C02F2101/306 , C02F2101/36 , C02F2305/08 , C09D167/04 , C09D171/02 , C12M21/18 , C12M23/06 , C12M23/16 , C12Q1/66 , C12Y113/12007 , C12Y114/16001 , D01D5/003 , D01D5/247 , D01F1/10 , D01F8/14 , G01N33/54393 , G01N2333/90241 , Y02W10/15 , Y10T428/1393
摘要： Provided is a method of attaching a molecule-of-interest to a microtube, by co-electrospinning two polymeric solutions through co-axial capillaries, wherein a first polymeric solution of the two polymeric solutions is for forming a shell of the microtube and a second polymeric solution of the two polymeric solutions is for forming a coat over an internal surface of the shell, the first polymeric solution is selected solidifying faster than the second polymeric solution and a solvent of the second polymeric solution is selected incapable of dissolving the first polymeric solution and wherein the second polymeric solution comprises the molecule-of-interest, thereby attaching the molecule-of-interest to the microtube. Also provided is an electrospun microtube comprising an electrospun shell, an electrospun coat over an internal surface of the shell and a molecule-of-interest attached to the microtube.
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26.发明公开COMPOSITIONS FOR DELIVERING ENZYMES INVOLVED IN AMINO ACID METABOLISM USING RECOMBINANT ADENO-ASSOCIATED VIRUS VIRONS (RAAV VIRONS), AND METHOD AND USE FOR TREATING AMINO ACID METABOLIC DISORDERS USING SUCH RAAV VIRONS 有权组成行政参与氨基酸代谢酶使用重组病毒腺相关病毒（rAAV病毒），和方法以及用于治疗氨基酸代谢紊乱使用这样的腺相关病毒的病毒粒子
公开(公告)号：EP1497436A1
公开(公告)日：2005-01-19
申请号：EP03717600.5
申请日：2003-04-16
申请人： Ozawa, Keiya , Mizukami, Hiroaki , Kume, Akihiro
发明人： Ozawa, Keiya , Mizukami, Hiroaki , Kume, Akihiro
CPC分类号： C12N15/86 , A61K38/44 , A61K47/6901 , A61K48/0075 , C12N2750/14143 , C12Y114/16001
摘要： Methods for delivering a heterologous gene to a mammalian subject using recombinant adeno-associated virus (rAAV) virions are described. Recombinant AAV virions containing a heterologous gene encoding a metabolic protein are delivered to a mammalian subject having a metabolic disorder. The rAAV virion-delivered heterologous gene is expressed at a therapeutic level thereby ameliorating a sign or symptom of the metabolic disease. Exemplary examples of metabolic diseases are those caused by defects in aromatic amino acid metabolism. Exemplary examples of heterologous genes include those encoding an aromatic amino acid hydroxylase, aromatic amino acid decarboxylase, and enzymes involved in tetrahydrobiopterin synthesis. Methods for treating phenylketonuria are also described.
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27.发明公开Phenylalanine hydroxylase cDNA clones, their methods of production and use in diagnosing classical phenylketonuria 失效苯丙氨酸羟脯氨酸CDNA克隆，其生产方法和用于诊断经典苯丙酸的方法
公开(公告)号：EP0126544A3
公开(公告)日：1986-12-03
申请号：EP84302559
申请日：1984-04-13
发明人： Woo, Savio L.C. , Thirumalachary, T. Chandra c/o T. Venkata Varadan , Lidsky, Alan S. , Robson, Kathryn J.H. Nuffield Department of
CPC分类号： C12N9/0071 , C12Q1/683 , C12Q1/6883 , C12Q2600/156 , C12Q2600/172 , C12Y114/16001
摘要： Described are phenylalanine hydroxylase cDNA clones, methods of their production, and the use of these clones in the diagnosis of the human genetic disorder, classical phenylketonuria (PKU), a hereditary disorder in phenylalanine metabolism that causes permanent mental retardation in humans, and the identification of heterozygous trait carriers.
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