公开(公告)号：EP2302074B1

公开(公告)日：2013-11-27

申请号：EP10175659.1

申请日：2003-12-05

申请人： Ibis Biosciences, Inc.

发明人： Ecker, David J. ,  Crooke, Stanley T. ,  Blyn, Lawrence B. ,  Hall, Thomas A. ,  Jiang, Yun ,  Griffey, Richard H. ,  Sampath, Rangarajan ,  Hofstadler, Steven A. ,  McNeil, John ,  Hannis, James C. ,  White, Neill ,  Samant, Vivek ,  Eshoo, Mark W. ,  Drader, Jared J.

IPC分类号： C12Q1/68 ,  C12P19/34 ,  C07H21/04

CPC分类号： C12Q1/686 ,  C12Q1/6806 ,  C12Q1/6844 ,  C12Q1/6858 ,  C12Q1/6872 ,  C12Q1/6888 ,  C12Q1/689 ,  C12Q2600/156 ,  G01N2333/28 ,  G01N2333/32 ,  G01N2333/35 ,  G01N2333/36 ,  C12Q2563/167 ,  C12Q2545/101 ,  C12Q2531/113 ,  C12Q2565/627 ,  C12Q2545/113

摘要： The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.

摘要翻译： 本发明提供一种用于线粒体DNA和用于表征线粒体DNA，其可用于评估线粒体疾病的进展的方法异质快速法医分析方法。

公开(公告)号：EP2657704A1

公开(公告)日：2013-10-30

申请号：EP13003285.7

申请日：2010-01-05

申请人： Otsuka Pharmaceutical Co., Ltd.

发明人： Masuda, Hisayo ,  Ishikawa, Yuichi ,  Sato, Ayumi ,  Tanaka, Hideaki

IPC分类号： G01N33/569 ,  C07K16/10

CPC分类号： G01N33/56983 ,  C07K16/1018 ,  G01N33/56911 ,  G01N2333/28 ,  G01N2333/285

摘要： An immunological assay method for detection of all Haemophilus influenzae strains in respiratory tract infection, otitis media or sepsis in infants or children, said method comprising measuring the amount of the P6 antigen contained in a test sample from a patient and employing a polyclonal antibody which recognizes the P6 antigen of Haemophilus influenzae, wherein said method employs an ELISA system or an immunochromatography assay system.

摘要翻译： 一种用于检测呼吸道感染，中耳炎或婴儿或儿童败血症的所有流感嗜血杆菌菌株的免疫测定方法，所述方法包括测量来自患者的测试样品中含有的P6抗原的量，并使用识别的多克隆抗体 流感嗜血杆菌的P6抗原，其中所述方法采用ELISA系统或免疫色谱测定系统。

公开(公告)号：EP2375253A1

公开(公告)日：2011-10-12

申请号：EP10729159.3

申请日：2010-01-05

申请人： Otsuka Pharmaceutical Co., Ltd.

发明人： MASUDA, Hisayo ,  ISHIKAWA, Yuichi ,  SATO, Ayumi ,  TANAKA, Hideaki

IPC分类号： G01N33/569 ,  G01N33/543

CPC分类号： G01N33/56983 ,  C07K16/1018 ,  G01N33/56911 ,  G01N2333/28 ,  G01N2333/285

摘要： Provided is an immunoassay method whereby all Haemophilus influenzae strains can be simultaneously detected at a high sensitivity. Specifically provided is a method for immunoassaying all Haemophilus influenzae strains characterized in that an antibody that recognizes P4 antigen or P6 antigen of influenza viruses is used.

摘要翻译： 提供了一种免疫测定方法，其中可以以高灵敏度同时检测所有流感嗜血杆菌菌株。 具体提供的是用于免疫测定所有流感嗜血杆菌菌株的方法，其特征在于使用识别流感病毒的P4抗原或P6抗原的抗体。

公开(公告)号：EP2302074A1

公开(公告)日：2011-03-30

申请号：EP10175659.1

申请日：2003-12-05

申请人： Ibis Biosciences, Inc.

发明人： Ecker, David J. ,  Crooke, Stanley T. ,  Blyn, Lawrence B. ,  Hall, Thomas A. ,  Jiang, Yun ,  Griffey, Richard H. ,  Sampath, Rangarajan ,  Hofstadler, Steven A. ,  McNeil, John ,  Hannis, James C. ,  White, Neill ,  Samant, Vivek ,  Eshoo, Mark W. ,  Drader, Jared, J.

IPC分类号： C12Q1/68 ,  C12P19/34 ,  C07H21/04

CPC分类号： C12Q1/686 ,  C12Q1/6806 ,  C12Q1/6844 ,  C12Q1/6858 ,  C12Q1/6872 ,  C12Q1/6888 ,  C12Q1/689 ,  C12Q2600/156 ,  G01N2333/28 ,  G01N2333/32 ,  G01N2333/35 ,  G01N2333/36 ,  C12Q2563/167 ,  C12Q2545/101 ,  C12Q2531/113 ,  C12Q2565/627 ,  C12Q2545/113

摘要： The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.

公开(公告)号：EP1573065A2

公开(公告)日：2005-09-14

申请号：EP03810055.8

申请日：2003-12-05

申请人： ISIS PHARMACEUTICALS, INC.

发明人： ECKER, David, J. ,  CROOKE, Stanley, T. ,  BLYN, Lawrence, B. ,  HALL, Thomas, A. ,  JIANG, Yun ,  GRIFFEY, Richard, H. ,  SAMPATH, Rangarajan ,  HOFSTADLER, Steven, A. ,  MCNEIL, John ,  HANNIS, James, C. ,  WHITE, Neil ,  SAMANT, Vivek ,  ESHOO, Mark, W. ,  DRADER, Jared, J.

IPC分类号： C12Q1/68 ,  C12P19/34 ,  C07H21/04

CPC分类号： C12Q1/686 ,  C12Q1/6806 ,  C12Q1/6844 ,  C12Q1/6858 ,  C12Q1/6872 ,  C12Q1/6888 ,  C12Q1/689 ,  C12Q2600/156 ,  G01N2333/28 ,  G01N2333/32 ,  G01N2333/35 ,  G01N2333/36 ,  C12Q2563/167 ,  C12Q2545/101 ,  C12Q2531/113 ,  C12Q2565/627 ,  C12Q2545/113

摘要： The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.

公开(公告)号：EP1358479A2

公开(公告)日：2003-11-05

申请号：EP01975178.3

申请日：2001-09-25

申请人： Acuabiotec LLC

发明人： VILLAMAR, Daniel, F.AcuaBiotec LLCEcuador Office ,  MORIARTY, David, J., W.

IPC分类号： G01N33/48

CPC分类号： H04L29/06027 ,  A01K29/00 ,  C12Q1/10 ,  G01N2333/28 ,  G06F19/00 ,  G16H50/80 ,  H04L65/80 ,  H04L67/12 ,  Y02A90/24 ,  Y02A90/26

摘要： A system, method and computer program product for controlling disease at an end user location, including (a) testing a range of candidates including at least one of: (i) Bacillus species, (i) Bacillus strains, (iii) species of beneficial bacteria (iv) strains of beneficial bacteria and (v) strains of beneficial bacterial viruses, against samples including at least one of pathogenic Vibrio, Gram negative pathogenic bacteria and Gram positive pathogenic bacteria taken from an end user location; (b) performing at least one of the following steps: (i) selecting one or more of the candidates that one of inhibit and attack at least one of the samples by direct inhibition of at least one of in situ antibiotic production, competitive exclusion, production of enzymes that degrade quorum sensing molecules, and (ii) testing a range of quorum sensing inhibitor compounds against the samples; and (c) performing the steps (a) and (b) for the end user location, including one of a country, major region and individual end user location, to target microbial technology to use in bio-control of disease specific to the end user location.