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公开(公告)号：EP2311992B1
公开(公告)日：2013-02-13
申请号：EP10179791.8
申请日：2002-03-04
发明人： Ecker, David J. , Griffey, Richard H. , Sampath, Rangarajan , Hofstadler, Steven , McNeil, John
CPC分类号： C12Q1/689 , C12Q1/686 , C12Q2600/156 , C12Q2565/627
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公开(公告)号：EP2333118B1
公开(公告)日：2013-12-18
申请号：EP10179789.2
申请日：2002-03-04
发明人： Ecker, David J. , Griffey, Richard H. , Sampath, Rangarajan , Hofstadler, Steven , McNeil, John
CPC分类号： C12Q1/689 , C12Q1/686 , C12Q2600/156 , C12Q2565/627
摘要： Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of nucleic acids derived from a bioagent and which bracket variable sequence regions that uniquely identify the bioagent. The result is a "base" composition signature" (BCS) which is then matched against a database of base composition signatures, by which the bioagent is identified.
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公开(公告)号：EP2333118A1
公开(公告)日：2011-06-15
申请号：EP10179789.2
申请日：2002-03-04
发明人： Ecker, David J. , Griffey, Richard H. , Sampath, Rangarajan , Hofstadler, Steven , McNeil, John
CPC分类号： C12Q1/689 , C12Q1/686 , C12Q2600/156 , C12Q2565/627
摘要： Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of nucleic acids derived from a bioagent and which bracket variable sequence regions that uniquely identify the bioagent. The result is a "base" composition signature" (BCS) which is then matched against a database of base composition signatures, by which the bioagent is identified.
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4.发明授权Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy 有权一种用于线粒体DNA的快速法医分析和表征的线粒体DNA的异质性过程
公开(公告)号：EP2302074B1
公开(公告)日：2013-11-27
申请号：EP10175659.1
申请日：2003-12-05
发明人： Ecker, David J. , Crooke, Stanley T. , Blyn, Lawrence B. , Hall, Thomas A. , Jiang, Yun , Griffey, Richard H. , Sampath, Rangarajan , Hofstadler, Steven A. , McNeil, John , Hannis, James C. , White, Neill , Samant, Vivek , Eshoo, Mark W. , Drader, Jared J.
CPC分类号： C12Q1/686 , C12Q1/6806 , C12Q1/6844 , C12Q1/6858 , C12Q1/6872 , C12Q1/6888 , C12Q1/689 , C12Q2600/156 , G01N2333/28 , G01N2333/32 , G01N2333/35 , G01N2333/36 , C12Q2563/167 , C12Q2545/101 , C12Q2531/113 , C12Q2565/627 , C12Q2545/113
摘要： The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.
摘要翻译： 本发明提供一种用于线粒体DNA和用于表征线粒体DNA，其可用于评估线粒体疾病的进展的方法异质快速法医分析方法。
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公开(公告)号：EP2311992A1
公开(公告)日：2011-04-20
申请号：EP10179791.8
申请日：2002-03-04
发明人： Ecker, David J. , Griffey, Richard H. , Sampath, Rangarajan , Hofstadler, Steven , McNeil, John
CPC分类号： C12Q1/689 , C12Q1/686 , C12Q2600/156 , C12Q2565/627
摘要： Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of nucleic acids derived from a bioagent and which bracket variable sequence regions that uniquely identify the bioagent. The result is a "base" composition signature" (BCS) which is then matched against a database of base composition signatures, by which the bioagent is identified.
摘要翻译： 检测和鉴定未知生物试剂（包括细菌，病毒等）的方法，通过核酸扩增和分子量测定的组合使用引物，所述引物与衍生自生物试剂的核酸的保守序列区杂交，并且独特地包围可变序列区 确定生物制剂。 结果是“基本”组成签名“（BCS），然后将其与基本组成签名的数据库进行匹配，通过该数据库识别生物因子。
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6.发明公开Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy 有权一种用于线粒体DNA的快速法医分析和表征的线粒体DNA的异质性过程
公开(公告)号：EP2302074A1
公开(公告)日：2011-03-30
申请号：EP10175659.1
申请日：2003-12-05
发明人： Ecker, David J. , Crooke, Stanley T. , Blyn, Lawrence B. , Hall, Thomas A. , Jiang, Yun , Griffey, Richard H. , Sampath, Rangarajan , Hofstadler, Steven A. , McNeil, John , Hannis, James C. , White, Neill , Samant, Vivek , Eshoo, Mark W. , Drader, Jared, J.
CPC分类号： C12Q1/686 , C12Q1/6806 , C12Q1/6844 , C12Q1/6858 , C12Q1/6872 , C12Q1/6888 , C12Q1/689 , C12Q2600/156 , G01N2333/28 , G01N2333/32 , G01N2333/35 , G01N2333/36 , C12Q2563/167 , C12Q2545/101 , C12Q2531/113 , C12Q2565/627 , C12Q2545/113
摘要： The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.
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公开(公告)号：EP2322649B1
公开(公告)日：2013-12-18
申请号：EP10179795.9
申请日：2002-03-04
发明人： Ecker, David J. , Griffey, Richard H. , Sampath, Rangarajan , Hofstadler, Steven , McNeil, John
CPC分类号： C12Q1/689 , C12Q1/686 , C12Q2600/156 , C12Q2565/627
摘要： Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of nucleic acids derived from a bioagent and which bracket variable sequence regions that uniquely identify the bioagent. The result is a "base" composition signature" (BCS) which is then matched against a database of base composition signatures, by which the bioagent is identified.
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8.发明公开Method for rapid detection and identification of bioagents 有权Schnellverfahren zum Nachweis und zur Identifizierung von Bioagentien
公开(公告)号：EP2322649A1
公开(公告)日：2011-05-18
申请号：EP10179795.9
申请日：2002-03-04
发明人： Ecker, David J. , Griffey, Richard H. , Sampath, Rangarajan , Hofstadler, Steven , McNeil, John
CPC分类号： C12Q1/689 , C12Q1/686 , C12Q2600/156 , C12Q2565/627
摘要： Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of nucleic acids derived from a bioagent and which bracket variable sequence regions that uniquely identify the bioagent. The result is a "base" composition signature" (BCS) which is then matched against a database of base composition signatures, by which the bioagent is identified.
摘要翻译： 用于通过核酸扩增和分子量测定的组合来检测和识别未知生物标签的方法，所述引物与衍生自生物制剂的核酸的保守序列区域杂交的引物以及唯一地包含可变序列区域的引物 识别生物制剂。 结果是“基础”组合签名“（BCS），然后将其与基础组合签名的数据库进行匹配，通过该数据库识别生物标签。
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