公开(公告)号：EP1721161A2

公开(公告)日：2006-11-15

申请号：EP05722762.1

申请日：2005-02-09

申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY

发明人： HATTON, T., Alan ,  WANG, Daniel, I., C. ,  LAIBINIS, Paul ,  DITSCH, Andre

IPC分类号： G01N33/543 ,  G01N33/53 ,  G01N33/553 ,  G01N33/567 ,  G01N33/534

CPC分类号： C07K1/30 ,  B03C1/01 ,  C08K9/08 ,  C08K2201/014

摘要： The present invention relates to multi-polymer-coated magnetic nanoclusters, aqueous magnetic fluids comprising same, and methods of their use in separation procedures. The multi-polymer-coated magnetic nanoclusters comprise a super paramagnetic core, with a first polymer attached Thereto, which does not render the first polymer-super paramagnetic particle complex colloidally stake, and a second polymer attached thereto, which stabilizes the complex of minti-polymer-coated B0gnetïA nanoparticles. Methods of use comprise methods of separation, including separation of expressed protein from cells and viruses expressing the same.

公开(公告)号：EP1513866A4

公开(公告)日：2006-07-12

申请号：EP03760393

申请日：2003-06-17

申请人： ABBOTT LAB

发明人： SHAH DINESH O ,  CHANG CHI-DEU ,  BATAC-HERMAN IRENA H

IPC分类号： G01N33/543 ,  G01N33/531 ,  G01N33/547 ,  C07K1/04 ,  C07K1/13 ,  C07K17/06 ,  C07K17/10 ,  G01N33/533 ,  G01N33/534 ,  G01N33/546 ,  G01N33/548

CPC分类号： G01N33/531

摘要： The subject invention relates to a conjugate which may be used for the detection of an analyte in a test sample. In particular, the conjugate comprises a heterophilic carrier, at least 10 label groups, an analyte-specific binding pair member (e.g., an antibody or antigen with complexes with the antigen or antibody of interest, respectively) as well as a heterophilic linker which indirectly attaches the acridinium-containing compounds to the analyte-specific binding pair member.

公开(公告)号：EP0790062B1

公开(公告)日：2006-05-10

申请号：EP96928704.4

申请日：1996-08-30

申请人： TORAY INDUSTRIES, INC.

发明人： MATSUMORI, Akira

IPC分类号： A61K45/00 ,  A61K38/21 ,  G01N33/534

CPC分类号： G01N33/534 ,  A61K38/21 ,  A61K38/215 ,  A61K45/00 ,  G01N33/5767 ,  G01N2333/18 ,  G01N2469/20

摘要： A remedy for heart diseases wherein the cardiac muscular tissue is infected with human hepatitis C virus which comprises as the active ingredient an antiviral agent. The remedy is useful in treating viral myocarditis and heart diseases in association therewith.

公开(公告)号：EP0939817B1

公开(公告)日：2005-11-23

申请号：EP97933333.3

申请日：1997-07-09

申请人： BAYER CORPORATION

发明人： GREVE, Jeffrey ,  SHANAFELT, Armen, B. ,  ROCZNIAK, Steven

IPC分类号： C12N15/24 ,  C07K14/54 ,  C07K14/715 ,  A61K38/20 ,  G01N33/534

CPC分类号： G01N33/6869 ,  A61K38/00 ,  C07K14/5406 ,  C07K14/7155 ,  G01N33/54306

摘要： A recombinant human IL-4 mutein numbered in accordance with wild-type IL-4 wherein the mutein comprises at least one amino acid substitution in the binding surface of either the A- or C-alpha helices of the wild-type IL-4 whereby the mutein binds to the IL-4R alpha receptor with at least greater affinity than native IL-4. The substitution is more preferably selected from the group of positions consisting of, in the A-helix, positions 13 and 16, and in the C-helix, positions 81 and 89. A most preferred embodiment is the recombinant human IL-4 mutein wherein the substitution at position 13 is Thr to Asp. Pharmaceutical compositions, amino acid and polynucleotide sequences encoding the muteins, transformed host cells, antibodies to the muteins, and methods of treatment are also described.

公开(公告)号：EP1532174A4

公开(公告)日：2005-08-10

申请号：EP03731327

申请日：2003-06-12

申请人： IMMUNOGEN INC

发明人： SINGH RAJEEVA ,  TAVARES DANIEL J ,  DAGDIGIAN NANCY E

IPC分类号： G01N33/534 ,  A61K39/395 ,  A61P35/00 ,  A61P43/00 ,  C07K16/18 ,  C07K16/28 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/06 ,  C12N5/10 ,  C12N5/16 ,  C12N15/09 ,  C12N15/13 ,  C12N15/62 ,  C12P21/02 ,  C12P21/08 ,  G01N33/53 ,  C07K16/00 ,  C07H21/04 ,  C12N15/00

CPC分类号： A61K39/39558 ,  A61K31/337 ,  A61K31/4745 ,  A61K39/39541 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/2863 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  A61K2300/00

公开(公告)号：EP0912741B1

公开(公告)日：2004-07-28

申请号：EP97927864.5

申请日：1997-05-30

申请人： Bayer Corporation

发明人： SHANAFELT, Armen, B. ,  GREVE, Jeffrey ,  GUNDEL, Robert

IPC分类号： C12N15/24 ,  C07K14/54 ,  A61K38/20 ,  C12N1/21 ,  G01N33/534

CPC分类号： C07K14/5406 ,  A61K38/00 ,  Y02A50/401

摘要： The invention is directed to human IL-4 muteins numbered in accordance with wild-type IL-4 having T-cell activating activity, but having reduced endothelial cell activating activity. In particular, the invention is related to human IL-4 muteins wherein the surface-exposed residues of the D helix of the wild-type IL-4 are mutated whereby the resulting mutein causes T-cell proliferation, and causes reduced IL-6 secretion from HUVECs, relative to wild-type IL-4. This invention realizes a less toxic IL-4 mutant that allows greater therapeutic use of this interleukin. Further, the invention is directed to IL-4 muteins having single, double and triple mutations represented by the designators R121A, R121D, R121E, R121F, R121H, R121I, R121K, R121N, R121P, R121T, R121W; Y124A, Y124Q, Y124R, Y124S, Y124T; Y124A/S125A, T13D/R121E; and R121T/E122F/Y124Q, when numbered in accordance with wild-type IL-4 (His=1). The invention also includes polynucleotides coding for the muteins of the invention, vectors containing the polynucleotides, transformed host cells, pharmaceutical compositions comprising the muteins, and therapeutic methods of treatment.

公开(公告)号：EP0734264B1

公开(公告)日：2004-02-18

申请号：EP95900421.9

申请日：1994-10-26

申请人： THOMAS JEFFERSON UNIVERSITY

发明人： WALDMAN, Scott A.

IPC分类号： A61K38/10 ,  G01N33/534 ,  G01N33/532 ,  G01N33/566 ,  A61K47/48 ,  A61K51/08 ,  A61P35/04

CPC分类号： C07K7/08 ,  A61K38/00 ,  A61K47/6425 ,  A61K51/08 ,  A61K51/088 ,  A61K2121/00 ,  C07K14/24 ,  G01N33/57446 ,  G01N2333/245

摘要： Conjugated compounds which comprise an ST receptor binding moiety and a radiostable active moiety are disclosed. Pharmaceutical compositions comprising conjugated compound which comprises an ST receptor binding moiety and a radiostable active moiety or an ST receptor binding moiety and a radioactive active moiety are disclosed. Methods of treating an individual suspected of suffering from metastasized colorectal cancer are disclosed. Methods of radioimaging metastasized colorectal cancer cells are disclosed. In vitro methods, kits and reagents are disclosed for determining whether or not an individual has metastasized colorectal cancer cells, for determining whether tumor cells are colorectal in origin and for analyzing tissue samples from the colon tissue to evaluate the extent of metastasis of colorectal tumor cells.

公开(公告)号：EP1268524A2

公开(公告)日：2003-01-02

申请号：EP01923058.0

申请日：2001-04-03

申请人： Dyax Corp.

发明人： RONDON, Isaac, Jesus ,  LADNER, Robert, Charles

IPC分类号： C07K7/06 ,  C07K7/08 ,  G01N33/534 ,  G01N33/574 ,  A61K38/08 ,  A61K38/10 ,  C12N15/63 ,  A61P35/00

CPC分类号： C07K7/06 ,  C07K7/08 ,  C07K14/705

摘要： The present invention provides binding moieties for CEA, which have a variety of uses wherever detecting, isolating or localizing CEA, and particularly CEA as opposed to cross-reactive antigens such as NCA, is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding CEA, which is overexpressed in adenocarcinomas of endodermally derived digestive system epithelia and fetal colon. Such polypeptides and disclosed derivatives are useful, e.g., as imaging agents for CEA-expressing tumors.

公开(公告)号：EP1218414A2

公开(公告)日：2002-07-03

申请号：EP00979484.3

申请日：2000-10-05

申请人： Abken, Hinrich

发明人： Abken, Hinrich

IPC分类号： C07K16/00 ,  C07K16/46 ,  A61K51/10 ,  G01N33/534 ,  C12N15/13 ,  C12N15/63 ,  C12N5/10

CPC分类号： C07K16/303 ,  A61K2039/505 ,  C07K16/3046 ,  C07K2317/622 ,  C07K2319/00

摘要： The invention relates to polypeptides which display binding specificity for the CA19-9 antigen, production of said polypeptides and their use for detection and elimination of CA19-9 antigen positive cells, i.e. for tumour diagnosis and therapy. The invention furthermore relates to radio-labelled derivatives of said polypeptides, production of said radio-labelled derivatives and their use in radioimmunoassays, radioscintigraphy and radioimmunotherapy; also coupling products of said polypeptides with indicator substances or pharmacologically effective substances.

公开(公告)号：EP0864088A4

公开(公告)日：2002-04-10

申请号：EP96941943

申请日：1996-10-21

申请人： UNIV NEW YORK STATE RES FOUND

发明人： GONG JOSEPH K ,  GLOMSKI CHESTER A

IPC分类号： C12N15/09 ,  C07K14/705 ,  C07K16/28 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/53 ,  G01N33/569 ,  G01N33/577 ,  G01N33/80 ,  G01N33/84 ,  G01N33/533 ,  G01N33/534 ,  G01N33/566

CPC分类号： G01N33/80 ,  C07K14/70582 ,  C07K16/2881 ,  C12Q1/6876 ,  G01N33/5014 ,  G01N33/56966 ,  G01N33/84 ,  G01N2333/79 ,  Y10S436/805 ,  Y10S436/811 ,  Y10T436/13