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21.发明公开SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE AND/OR OTHER FOLATE METABOLIZING ENZYMES INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME 审中-公开PROTON耦合式选择性FOLATTRANSPORTER和叶酸受体抑制剂的化合物GARFTASE和/或其他FOLATMETABOLISIERUNGSENZYMEN及其使用方法
公开(公告)号：EP2627332A4
公开(公告)日：2014-08-20
申请号：EP11833198
申请日：2011-10-10
发明人： GANGJEE ALEEM , MATHERLY LARRY H
IPC分类号： A61K31/519 , A61P35/00 , A61P37/06 , C07D487/04 , C07D491/048 , C12N5/09 , C12N9/99
CPC分类号： C07D487/04 , A61K31/519 , C07D491/048 , C12N9/99
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22.发明公开METALLODRUGS HAVING IMPROVED PHARMACOLOGICAL PROPERTIES, AND METHODS OF MANUFACTURE AND USE THEREOF 审中-公开随着对生产和使用改进的药理特性和方法METALLODRUGS
公开(公告)号：EP2707394A2
公开(公告)日：2014-03-19
申请号：EP12782334.2
申请日：2012-05-12
申请人： Metallopharm LLC
IPC分类号： C07K19/00 , C07K5/068 , C07K7/08 , C07K14/46 , C07H23/00 , C07K2/00 , C07K1/113 , C12N9/99 , A61K38/05 , A61K38/10 , A61K38/17 , A61K38/08
CPC分类号： C07K14/825 , A61K31/424 , A61K38/00 , A61K38/10 , A61K38/16 , A61K47/547 , C07F17/02 , C07H21/00 , C07H23/00 , C07K5/022 , C07K7/06 , C07K2319/20 , C07K2319/70
摘要： It is an object of the present invention to provide improved pharmacological properties to molecules which bind to a target with low affinity (hereinafter referred to as a "ligand moiety") through linkage of such molecules to a metal binding moiety, thereby generating a combination molecule commonly referred to as a "metallodrug" or "metallotherapeutic." The metal binding domain of metallodrugs typically catalyzes oxido- reductase chemistry or acts as a Lewis-Acid catalyst, resulting in modification of proteins and nucleic acids that are in close proximity due to binding of the ligand moiety to its target.
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23.发明公开PANCREATIC ISLET SEPARATION METHOD, AND PROTECTIVE SOLUTION FOR PROTECTING PANCREATIC ISLET TISSUE 有权胰腺岛间距和保护解决方案来保护岛上的胰腺组织
公开(公告)号：EP2594634A4
公开(公告)日：2014-01-01
申请号：EP11806826
申请日：2011-07-13
申请人： OTSUKA PHARMA CO LTD
发明人： TANEMURA MASAHIRO , SAWA YOSHIKI , MYOUI AKIRA , ITO TOSHINORI , MORI MASAKI , DOKI YUICHIRO
CPC分类号： C12N5/0676 , C12N2501/734
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24.发明公开METHODS FOR THE REGULATION OF THE PROSTAGLANDIN F SYNTHASE (PGFS) ACTIVITY OF AKR1B1 AND USES THEREOF 审中-公开方法调节前列腺素合成酶（PGFS-）AKR1B1的活度及其用途
公开(公告)号：EP2220216A4
公开(公告)日：2013-03-20
申请号：EP08850869
申请日：2008-11-14
申请人： UNIV LAVAL
发明人： FORTIER MICHEL , CHAPDELAINE PIERRE , BRESSON EVA , MADORE ERIC
IPC分类号： C12N5/10 , A61K31/713 , A61K39/395 , A61K48/00 , C12N5/071 , C12N5/077 , C12N9/02 , C12N9/99 , C12N15/113 , C12Q1/02 , C12Q1/32 , G01N33/573 , C12N5/08
CPC分类号： A61K31/517 , A61K31/197 , A61K31/4188 , A61K31/426 , A61K31/501 , A61K31/713 , C12N15/1137 , C12N2310/14 , C12N2503/02 , C12Q1/26 , C12Y101/01188 , G01N33/88 , G01N2333/902 , G01N2500/10 , G01N2800/52
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公开(公告)号：EP2427446A4
公开(公告)日：2012-10-31
申请号：EP10771936
申请日：2010-05-04
IPC分类号： C07D309/30 , A61K31/351 , A61P31/00 , C07H19/10 , C12N9/24 , C12N9/99
CPC分类号： C07D309/30
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26.发明公开MODULATION OF PHOSPHOLIPASE D FOR THE TREATMENT OF THE ACUTE AND CHRONIC EFFECTS OF ETHANOL 审中-公开控制调节磷脂酶D治疗急性和乙醇的慢性影响
公开(公告)号：EP2483405A1
公开(公告)日：2012-08-08
申请号：EP10805031.1
申请日：2010-07-29
IPC分类号： C12N9/99
CPC分类号： C12N9/16 , A61K31/05 , A61K31/381 , A61K31/4184 , C12N9/20
摘要： The present invention relates to methods of decreasing the negative effects of alcohol on behavior as well as inhibiting the toxic effects of alcohol, comprising administering, to a subject, an effective amount of an inhibitor of phospholipase D.
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公开(公告)号：EP2251024A4
公开(公告)日：2011-12-28
申请号：EP09703148
申请日：2009-01-21
申请人： KANEKA CORP
CPC分类号： A61K36/00 , A23L33/105
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28.发明公开BRIDGED SECONDARY AMINES AND USE THEREOF AS IAP BIR DOMAIN BINDING COMPOUNDS 审中-公开BRIDGED仲胺和它们的用途至于IAP BIR结构域结合的化合物
公开(公告)号：EP2310402A1
公开(公告)日：2011-04-20
申请号：EP09768679.4
申请日：2009-06-26
IPC分类号： C07K5/062 , A61K38/04 , A61P35/00 , C07K5/00 , C07K5/06 , C12Q1/00 , G01N33/53 , C07K14/81 , C12N9/64 , C12N9/99
CPC分类号： G01N33/6872 , A61K38/00 , C07K5/06026 , G01N2333/4704 , G01N2500/00
摘要： A compound of Formula 1.1A: 1.1A or salt thereof, as well as methods of making compounds of Formula 1.1A, methods of using compounds of Formula 1.1A to treat proliferative disorders such as cancer, and related compounds, composition, and methods.
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公开(公告)号：EP2177529A4
公开(公告)日：2011-04-20
申请号：EP08790127
申请日：2008-07-01
申请人： YAKULT HONSHA KK
发明人： ABE ATSUHIRO , SHIMIZU HIDEAKI , SAWADA SEIGO , KODAIRA HIROSHI
IPC分类号： C07K5/062 , A61K38/00 , A61K38/55 , A61P1/18 , A61P3/10 , A61P21/02 , A61P25/00 , A61P25/08 , A61P25/28 , A61P43/00 , C07C323/59 , C07K5/065 , C07K5/08 , C12N9/99
CPC分类号： C07K5/0207 , A61K38/00
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公开(公告)号：EP2265275A2
公开(公告)日：2010-12-29
申请号：EP09716971.8
申请日：2009-03-05
IPC分类号： A61K31/7052 , C07H7/00 , C12N9/99 , A61P35/00 , A61P31/12
CPC分类号： C12N9/99 , C07D487/06 , C07D491/06 , C07D498/06 , C12N9/1241
摘要： The invention provides compounds of Formula I: [Formula I] as described herein, as well as pharmaceutical compositions comprising the compounds, and synthetic methods and intermediates that are useful for preparing the compounds. The compounds of Formula (I) are useful as anti-viral agents and/or as anti-cancer agents.
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