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公开(公告)号：EP2337797A2
公开(公告)日：2011-06-29
申请号：EP09789183.2
申请日：2009-08-21
申请人： Fibrogen, Inc.
摘要： The present invention relates to double-crosslinked collagen materials, methods for preparing double- crosslinked collagen materials, and methods of using double-crosslinked collagen materials
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32.发明公开PYRROLO [ 1, 2 -B] PYRIDAZINE DERIVATIVES AND THEIR USE AS HIF MODULATORS 有权PYRROLO [1，2 -B] PYRIDAZINDERIVATE UND IHRE VERWENDUNG ALS HIF-MODULATOREN
公开(公告)号：EP2334682A1
公开(公告)日：2011-06-22
申请号：EP09791730.6
申请日：2009-08-20
申请人： Fibrogen, Inc.
发明人： DENG, Shaojiang , HO, Wen-Bin , FLIPPIN, Lee A.
IPC分类号： C07D487/04 , A61K31/519 , A61P9/00
CPC分类号： C07D487/04
摘要： The present invention relates to novel compounds capable of modulating the stability and/or activity of hypoxia inducible factor (HIF) by inhibiting the activity of at least one HIF hydroxylase enzyme.
摘要翻译： 本发明涉及能够通过抑制至少一种HIF羟化酶的活性来调节缺氧诱导因子（HIF）的稳定性和/或活性的新型化合物。
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公开(公告)号：EP1942985B1
公开(公告)日：2011-04-27
申请号：EP06759197.4
申请日：2006-05-05
申请人： FIBROGEN, INC.
IPC分类号： C07K16/22 , A61K39/395 , A61P9/12 , C12N15/113 , A61K31/713 , A61K31/7088
CPC分类号： C07K16/22 , A61K2039/505
摘要： The present invention relates to methods and agents for reducing blood pressure. Methods and agents for reducing diastolic blood pressure, for reducing systolic blood pressure, and for reducing mean arterial pressure are also provided.
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公开(公告)号：EP2298301A2
公开(公告)日：2011-03-23
申请号：EP10181796.3
申请日：2002-12-06
申请人： Fibrogen, Inc.
发明人： KLAUS, Stephen J. , LIN, Al Y. , NEFF, Thomas B. , WANG, Qingjian , GUENZLER-PUKALL, Volkmar , AREND, Michael P. , FLIPPIN, Lee A.
IPC分类号： A61K31/47 , A61K31/4738 , A61K31/63 , A61K38/17 , A61K31/00 , C07K14/47 , C07K14/505 , A61P7/06
CPC分类号： A61K31/4745 , A61K31/00 , A61K31/17 , A61K31/4375 , A61K31/44 , A61K31/4418 , A61K31/47 , A61K31/472 , A61K31/4738 , A61K31/496 , A61K31/63 , A61K38/1709 , C07K14/4702 , C07K14/505 , G01N33/746
摘要： The present invention relates to compounds for use in methods for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo . Compounds for use in methods for treating, pretreating or preconditioning, or preventing erythropoietin-associated conditions are also included.
摘要翻译： 本发明涉及用于通过在体外和体内增加内源促红细胞生成素来治疗促红细胞生成素相关病症的方法中使用的化合物。 还包括用于治疗，预处理或预处理或预防促红细胞生成素相关病症的方法的化合物。
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公开(公告)号：EP1654282B1
公开(公告)日：2010-12-01
申请号：EP04779661.0
申请日：2004-07-30
申请人： FIBROGEN, INC.
CPC分类号： A61K9/2077 , A61K9/4825 , C07K14/78
摘要： The invention relates to recombinant gelatins, and to recombinant gelatins useful in gelatin capsule manufacture, and to compositions, gelatin capsules, and gelatin films comprising these, as well as methods of production.
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36.发明授权Method for detecting connective tissue growth factor for diagnosing a renal disorder 有权一种用于检测结缔组织生长因子肾疾病的诊断方法
公开(公告)号：EP1112088B1
公开(公告)日：2010-10-27
申请号：EP99948154.2
申请日：1999-09-08
IPC分类号： A61K39/395 , A61K38/28 , G01N33/68
CPC分类号： C07K16/22 , A61K38/00 , A61K39/395 , C07K2317/73 , A61K2300/00
摘要： The present invention relates to methods for detecting, preventing, and treating the progression of pathologies characterized by an accumulation of the extracellular matrix components by providing an agent to regulate, inhibit, or modulate the activity of Connective Tissue Growth Factor (CTGF). The method of the present invention is directed to treating kidney fibrosis and associated renal disorders, in particular, complications associated with diabetes and hypertension.
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公开(公告)号：EP1919463B1
公开(公告)日：2010-06-09
申请号：EP06784964.6
申请日：2006-06-15
申请人： FIBROGEN, INC.
IPC分类号： A61K31/00 , A61K31/4745 , A61K31/63 , A61P35/00
CPC分类号： A61K31/4745 , A61K31/00 , A61K31/19 , A61K31/195 , A61K31/63 , A61K38/16
摘要： The invention relates to methods and compounds for treating or preventing cancer. Methods for treating or preventing cancer, for inhibiting tumor growth, reducing tumor volume, inhibiting tumor progression, inhibiting metastasis, and improving survival are provided herein.
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38.发明授权Substituierte Isochinolin-3-Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel 有权取代的异喹啉-3-甲酰胺，其制备方法及其作为药物的用途
公开(公告)号：EP1538160B1
公开(公告)日：2009-06-03
申请号：EP05004047.6
申请日：1998-10-16
申请人： FIBROGEN, INC.
IPC分类号： C07K5/078 , C07D217/26 , A61K38/05 , A61K31/47
CPC分类号： C07K5/06139 , A61K38/00 , C07D217/26
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39.发明公开CYANOISOQUINOLINE COMPOUNDS THAT STABILIZE HYPOXIA INDUCIBLE FACTOR (HIF) 有权缺氧诱导因子稳定化CYANOISOCHINOLINE（HIF）
公开(公告)号：EP2044028A2
公开(公告)日：2009-04-08
申请号：EP07717454.8
申请日：2007-01-26
申请人： FIBROGEN, INC.
发明人： AREND, Michael, P. , FLIPPIN, Lee, A. , WU, Min , TURTLE, Eric, D. , HO, Wen-bin , DENG, Shaojiang
IPC分类号： C07D217/26 , C07D405/12 , C07D413/12 , C07D417/12 , A61K31/472 , A61K31/4725 , A61P7/06
CPC分类号： C07D217/26 , A61K31/435 , A61K31/44 , A61K31/47 , A61K31/472 , A61K45/06 , C07D405/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to cyanoisoquinoline compounds suitable for use in treating hypoxia inducible factor-mediated and/or erythropoietin-associated conditions. The cyanoisoquinoline compounds of the invention have the following structure: Formula (I).
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公开(公告)号：EP1605862A4
公开(公告)日：2008-09-03
申请号：EP04715728
申请日：2004-02-27
申请人： FIBROGEN INC
发明人： HILLAS PATRICK J , POLAREK JAMES W , YANG CHUNLIN
IPC分类号： A61L27/24 , A61F2/00 , A61K20060101 , A61K38/39 , A61L31/04
CPC分类号： A61L31/044 , A61K9/70 , A61L15/325 , A61L24/102 , A61L26/0033 , A61L27/24
摘要： The invention relates to biomaterials and, in particular, biomaterials containing collagen.
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