公开(公告)号：EP2956086B1

公开(公告)日：2018-11-28

申请号：EP14751102.6

申请日：2014-02-11

申请人： Case Western Reserve University

发明人： AKKUS, Ozan ,  KISHORE, Vipuil ,  YOUNESI, Mousa ,  ISLAM, Anowarul

IPC分类号： A61F2/02 ,  A61L15/32 ,  A61L27/24 ,  C07K14/78 ,  C08J9/28 ,  D01D5/00 ,  D01F4/00

CPC分类号： C25D1/18 ,  A61L26/0033 ,  A61L27/24 ,  A61L27/26 ,  B05D1/18 ,  C07K14/78 ,  D01D5/0076 ,  D01F4/00

摘要： Electrochemically aligned and compacted molecules, nanoparticles and microparticles with ampholytic nature, such as collagen, elastin, keratin and charged nanoparticle materials, methods of making and using the materials and associated production-related devices. In one embodiment, a device for producing continuous electrochemically aligned strands, threads or fibers is disclosed. In a further embodiment, fabrication of compositionally and geometrically complex anatomical forms by 3D-electrochemical compaction of biomolecules is disclosed. In yet another embodiment, methods for fabricating patterned lattice structures, in particular having controlled pore size and morphology, and the lattice structures themselves are also disclosed.

公开(公告)号：EP2442833B1

公开(公告)日：2018-10-17

申请号：EP10789079.0

申请日：2010-06-15

申请人： TheraDep Technologies, Inc.

发明人： O'KEEFFE, Joe ,  DOBBYN, Peter ,  O'DONOGHUE, John ,  O'NEILL, Liam

IPC分类号： A61L26/00 ,  A61L2/14 ,  A61B18/04 ,  A61L2/00 ,  B05D1/00 ,  H05H1/24 ,  H05H1/42 ,  H05H1/48

CPC分类号： A61L26/0057 ,  A61B18/042 ,  A61L2/0011 ,  A61L2/14 ,  A61L26/0019 ,  A61L26/0023 ,  A61L26/0033 ,  A61L26/0042 ,  A61L26/0066 ,  A61L26/009 ,  A61L2300/254 ,  A61L2300/258 ,  A61L2300/404 ,  A61L2300/412 ,  A61L2300/606 ,  A61L2300/64 ,  B05D1/62 ,  H05H1/2406 ,  H05H1/42 ,  H05H1/48 ,  H05H2001/483 ,  H05H2240/20 ,  H05H2245/122 ,  C08L67/04 ,  C08L5/08 ,  C08L5/04 ,  C08L1/00

摘要： A plasma coating device for treating a wound comprises a plasma chamber having: one or more electrodes, a gas supply inlet, a plasma outlet exposed to ambient pressure, and an ignition system operatively connected to the electrodes for providing a non-thermal equilibrium plasma within the plasma chamber. An aerosol delivery system is operable to introduce a bioresorbable material as an aerosol into the plasma, to produce a coating on the wound surface.

公开(公告)号：EP3373989A1

公开(公告)日：2018-09-19

申请号：EP16795312.4

申请日：2016-11-11

申请人： Biovotec AS

发明人： KENNY, Enda ,  SCHMIDT, Ralf ,  SUSO, Henri-Pierre ,  BARHAM, Paul

IPC分类号： A61L26/00

CPC分类号： A61F13/00012 ,  A61K9/0014 ,  A61K31/717 ,  A61L26/0023 ,  A61L26/0028 ,  A61L26/0033 ,  A61L26/0038 ,  A61L26/0057

摘要： The invention provides a dry biocompatible film comprising at least one film forming material and particulate egg shell membrane (ESM), wherein said particulate ESM is distributed substantially uniformly in and/or on the film and wherein said film, or portion thereof, disintegrates upon contact with a wound or an exudate thereof. The invention further provides methods for preparing the films of the invention and the uses thereof in methods to promote the healing of wounds.

公开(公告)号：EP3206670A4

公开(公告)日：2018-06-20

申请号：EP15851107

申请日：2015-10-14

申请人： LYNCH SAMUEL ,  WISNER LYNCH LESLIE

发明人： LYNCH SAMUEL ,  WISNER-LYNCH LESLIE

IPC分类号： A61K9/00 ,  A61K9/70 ,  A61K38/18 ,  A61K47/34 ,  A61K47/42 ,  A61L26/00 ,  A61P17/02

CPC分类号： A61L26/0066 ,  A61K9/0014 ,  A61K9/0024 ,  A61K9/7007 ,  A61K38/1858 ,  A61K47/34 ,  A61K47/42 ,  A61L26/0023 ,  A61L26/0033 ,  A61L26/0052 ,  A61L26/0085 ,  A61L26/0095 ,  A61L2300/414 ,  A61P17/02 ,  Y02A50/473

摘要： Novel compositions for treating wounds and promoting the healing thereof are described, including composition containing novel combinations of a carrier and recombinant platelet derived growth factor having fewer isoforms and enhanced biostability. Methods of treating wounds with novel therapeutic composition using dosing procedures leading to effective results with a minimal number of treatment applications are also described.

公开(公告)号：EP3256176A1

公开(公告)日：2017-12-20

申请号：EP16711018.8

申请日：2016-02-11

申请人： MiMedx Group, Inc.

发明人： KOOB, Thomas J. ,  MASSEE, Michelle

IPC分类号： A61L26/00

CPC分类号： A61L27/3604 ,  A61K9/14 ,  A61K9/7007 ,  A61K35/50 ,  A61K38/39 ,  A61L26/0033 ,  A61L26/0057 ,  A61L26/0061 ,  A61L26/0095 ,  A61L27/24 ,  A61L27/54 ,  A61L2430/10 ,  A61L2430/34

摘要： Described herein are compositions of collagen and micronized placental tissue components, methods for producing the same and methods for using the same for wound healing, repairing damaged tendons, cosmetic applications and covering biocompatible materials and/or devices.

公开(公告)号：EP3206670A1

公开(公告)日：2017-08-23

申请号：EP15851107.1

申请日：2015-10-14

申请人： Lynch, Samuel ,  Wisner-Lynch, Leslie

发明人： Lynch, Samuel ,  Wisner-Lynch, Leslie

IPC分类号： A61K9/14 ,  A61K38/18

CPC分类号： A61L26/0066 ,  A61K9/0014 ,  A61K9/0024 ,  A61K9/7007 ,  A61K38/1858 ,  A61K47/34 ,  A61K47/42 ,  A61L26/0023 ,  A61L26/0033 ,  A61L26/0052 ,  A61L26/0085 ,  A61L26/0095 ,  A61L2300/414 ,  A61P17/02 ,  Y02A50/473

摘要： Novel compositions for treating wounds and promoting the healing thereof are described, including composition containing novel combinations of a carrier and recombinant platelet derived growth factor having fewer isoforms and enhanced biostability. Methods of treating wounds with novel therapeutic composition using dosing procedures leading to effective results with a minimal number of treatment applications are also described.

摘要翻译： 描述了用于治疗伤口并促进其愈合的新型组合物，包括含有载体和重组血小板衍生生长因子的新组合的组合物，所述组合物具有更少的同种型和增强的生物稳定性。 还描述了使用给药程序治疗具有新治疗组合物的伤口的方法，导致有效结果和最少数量的治疗应用。

公开(公告)号：EP2976095A1

公开(公告)日：2016-01-27

申请号：EP14720324.4

申请日：2014-03-12

申请人： KCI Licensing, Inc.

发明人： LEUNG, Braden, King-Fung ,  WHELOVE, Ona ,  EDLUND, Chester, R. ,  HARPER, John, R.

IPC分类号： A61K38/01 ,  A61K38/39 ,  A61K45/00 ,  A61K31/14 ,  A61K31/19 ,  A61K31/198 ,  A61K31/353 ,  A61K33/30 ,  A61K33/34 ,  A61K33/38 ,  A61L26/00 ,  A61P17/02

CPC分类号： A61K38/39 ,  A61F13/00063 ,  A61F13/00068 ,  A61K9/0014 ,  A61K31/085 ,  A61K31/14 ,  A61K31/155 ,  A61K31/201 ,  A61K31/7036 ,  A61K31/785 ,  A61K33/00 ,  A61K33/04 ,  A61K33/30 ,  A61K33/34 ,  A61K33/38 ,  A61K35/76 ,  A61K36/232 ,  A61K36/54 ,  A61K36/61 ,  A61K36/886 ,  A61K38/014 ,  A61K38/40 ,  A61K45/06 ,  A61L15/325 ,  A61L15/425 ,  A61L15/46 ,  A61L26/0033 ,  A61L26/0066 ,  A61M1/0088 ,  A61M5/142 ,  A61K2300/00 ,  A61K36/14

摘要： Provided herein are biologically active solution compositions comprising one or more sacrificial proteolytic enzyme substrates, one or more preservatives, and one or more antimicrobial agents and methods of using the solution compositions to treat tissue sites, in particular chronic wounds. The compositions may be used in conjunction with negative pressure wound therapy to treat tissue sites.

摘要翻译： 本文提供了包含一种或多种牺牲蛋白水解酶底物，一种或多种防腐剂和一种或多种抗微生物剂的生物活性溶液组合物和使用该溶液组合物来治疗组织部位，特别是慢性伤口的方法。 组合物可以与负压伤口治疗联合使用以治疗组织部位。

公开(公告)号：EP2391394B1

公开(公告)日：2014-12-17

申请号：EP10700886.4

申请日：2010-01-08

申请人： MBP Medical Biomaterial Products GmbH

发明人： Barker, Stephen George Edward ,  Behjati, Barat

IPC分类号： A61L15/32 ,  A61L15/44 ,  A61L26/00

CPC分类号： A61L15/32 ,  A61L15/44 ,  A61L26/0033 ,  A61L26/0066 ,  A61L26/0071 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/414 ,  A61L2300/442

公开(公告)号：EP1404388B1

公开(公告)日：2013-10-23

申请号：EP02749693.4

申请日：2002-06-28

申请人： Cook Biotech, Inc.

发明人： PATEL, Umesh, H. ,  HILES, Michael, C. ,  HODDE, Jason, P.

IPC分类号： A61L27/24 ,  A61L26/00 ,  A61F2/02 ,  C07K14/78 ,  C12N5/00

CPC分类号： A61L27/3633 ,  A61L26/0033 ,  A61L26/0057 ,  A61L27/24 ,  A61L27/3604

公开(公告)号：EP2305320A3

公开(公告)日：2011-04-13

申请号：EP10011673.0

申请日：2004-06-19

申请人： Kensey Nash BVF Technology, LLC

发明人： Ringeisen, Timothy ,  Wattengel, William Christian

IPC分类号： A61L26/00 ,  A61L27/24 ,  A61L27/52 ,  C08L89/06 ,  C08H1/06 ,  A61L27/46

CPC分类号： A61L27/16 ,  A61B17/68 ,  A61B17/70 ,  A61B17/7062 ,  A61B17/72 ,  A61B2017/00526 ,  A61F2/0059 ,  A61F2/24 ,  A61F2/28 ,  A61F2/30756 ,  A61F2/3094 ,  A61F2/4241 ,  A61F2/44 ,  A61F2/4465 ,  A61F2002/30062 ,  A61F2002/4475 ,  A61F2002/4495 ,  A61F2210/0004 ,  A61F2310/00365 ,  A61L26/0033 ,  A61L26/008 ,  A61L27/12 ,  A61L27/18 ,  A61L27/20 ,  A61L27/225 ,  A61L27/227 ,  A61L27/24 ,  A61L27/26 ,  A61L27/3616 ,  A61L27/3804 ,  A61L27/3834 ,  A61L27/46 ,  A61L27/48 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L2300/112 ,  C08H1/06 ,  C08K3/013 ,  C08L5/04 ,  C08L5/08 ,  C08L67/04 ,  C08L89/06 ,  C08L2205/16

摘要： A process to create a malleable, biocompatible polymer material for the repair or replacement of tissue, comprising the steps of providing a vessel containing a slurry, said slurry comprising a plurality of polymer fibers and at least one suspension fluid, wherein the polymer fibers are substantially evenly dispersed and randomly oriented throughout the volume of the suspension fluid; applying a gyroscopic force to said vessel containing said slurry, in such a way that said gyroscopic force serves to cause said polymer fibers to migrate through the suspension fluid and amass, thereby forming a polymer material, with said polymer material comprising polymer fibers of sufficient length and sufficiently interlaced and interlocked to retard dissociation of said polymer fibers upon contact with a fluid, thereby forming a malleable, polymer material having a consistency like putty at least when hydrated; removing said polymer material from said vessel for implantation in said interlaced and interlocked form.

摘要翻译： 制备用于修复或更换组织的可延展的生物相容性聚合物材料的方法，包括以下步骤：提供含有浆料的容器，所述浆料包含多个聚合物纤维和至少一种悬浮液，其中聚合物纤维基本上 均匀分散并随机取向悬浮液体积; 将所述陀螺力施加到所述含有所述浆料的容器中，使得所述陀螺力用于使所述聚合物纤维迁移通过悬浮液并聚集，由此形成聚合物材料，所述聚合物材料包含足够长度的聚合物纤维 并且充分地交织和互锁以阻止所述聚合物纤维在与流体接触时的解离，由此形成至少在水合时具有如油灰的稠度的可延展的聚合物材料; 从所述容器中除去所述聚合物材料，以便以所述交织和互锁形式植入。