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1.发明公开
公开(公告)号：EP3710014A1
公开(公告)日：2020-09-23
申请号：EP18812529.8
申请日：2018-11-14
发明人： CHEN, Jieli , CHOPP, Michael
IPC分类号： A61K31/7088 , A61P9/00
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公开(公告)号：EP3401393B1
公开(公告)日：2020-02-19
申请号：EP18180526.8
申请日：2013-02-21
发明人： BRODIE, Chaya
IPC分类号： C12N5/079 , A61P25/00 , A61P25/16 , C12N15/113
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公开(公告)号：EP3515531A1
公开(公告)日：2019-07-31
申请号：EP17851750.4
申请日：2017-09-19
发明人： FRINAK, Stanley , ZASUWA, Gerard , YEE, Jerry , BESARAB, Anatole
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公开(公告)号：EP3423070A1
公开(公告)日：2019-01-09
申请号：EP17760888.2
申请日：2017-03-03
发明人： ZHANG, Zheng Gang , XIONG, Ye , CHOPP, Michael
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公开(公告)号：EP3401393A1
公开(公告)日：2018-11-14
申请号：EP18180526.8
申请日：2013-02-21
发明人： BRODIE, Chaya
IPC分类号： C12N5/079 , A61P25/00 , A61P25/16 , C12N15/113
CPC分类号： A61K35/30 , A61K35/28 , A61K35/50 , A61K35/51 , C12N5/0622 , C12N15/113 , C12N2310/141 , C12N2320/11 , C12N2330/10 , C12N2501/01 , C12N2501/11 , C12N2501/115 , C12N2501/135 , C12N2501/195 , C12N2501/41 , C12N2501/65 , C12N2502/13 , C12N2502/1305 , C12N2502/1311 , C12N2502/1317 , C12N2502/1323 , C12N2502/1329 , C12N2502/1335 , C12N2502/1341 , C12N2502/1347 , C12N2502/1352 , C12N2502/1358 , C12N2502/1364 , C12N2502/137 , C12N2502/1376 , C12N2502/1382 , C12N2502/1388 , C12N2502/1394 , C12N2506/025 , C12N2506/1353 , C12N2506/1369 , C12N2506/1384 , C12N2506/1392 , C12N2510/00 , C12Q1/6876 , C12Q2600/178
摘要： A method of generating astrocytes is disclosed, the method comprising up-regulating miR-101 and down-regulating miR-138 using an agent which hybridizes to the miRNA in mesenchymal stem cells (MSCs). Isolated cell populations and uses thereof are also disclosed.
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6.发明授权METHODS, SYSTEMS, AND COMPOSITIONS FOR CELL-DERIVED/VESICLE-BASED MICRORNA DELIVERY 有权细胞来源/基于微生物的微生物递送的方法，系统和组合物
公开(公告)号：EP2791336B1
公开(公告)日：2017-11-29
申请号：EP12809048.7
申请日：2012-12-13
IPC分类号： C12N15/113 , A61K31/713 , A61K35/28 , A61K9/127
CPC分类号： A61K35/28 , A61K9/127 , C12N15/111 , C12N15/113 , C12N2310/141 , C12N2320/32 , C12N2330/50
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7.发明授权THYMOSIN BETA4 FOR USE IN TREATING A NEURAL INJURY 有权THYMOSINE BETA4在DER VERWENDUNG ZUR BEHANDLUNG VON NEURONALE VERLETZUNG
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8.发明授权SYSTEM AND METHOD FOR DELIVERY OF REGIONAL CITRATE ANTICOAGULATION TO EXTRACORPOREAL BLOOD CIRCUITS 有权向体外血液循环递送区域性柠檬酸抗凝的系统和方法
公开(公告)号：EP2178596B1
公开(公告)日：2016-10-19
申请号：EP08789092.7
申请日：2008-08-08
发明人： SZAMOSFALVI, Balazs , FRINAK, Stanley , YEE, Jerry
CPC分类号： A61M1/3672 , A61M1/3406 , A61M1/3413 , A61M1/3434 , A61M1/3437 , A61M1/3441 , A61M1/3455 , A61M1/3458 , A61M1/3609 , A61M1/3653 , A61M1/3656 , A61M1/3658 , A61M1/3675 , A61M2202/0486 , A61M2205/3306
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公开(公告)号：EP3057646A1
公开(公告)日：2016-08-24
申请号：EP14854262.4
申请日：2014-10-13
申请人： The United States Of America,As Represented By The Secretary, Department Of Health And Human Services , Henry Ford Health System
CPC分类号： A61M29/00 , A61B17/00234 , A61B17/3478 , A61B2017/00247 , A61B2017/00336 , A61M25/0662
摘要： Technology disclosed herein provides a reduced transition between the edge of a rigid vascular dilator and the distal edge of the accompanying introducer sheath. Disclosed dilators can be segmented into two or more primarily longitudinally extending parts, can have rigid circumferential or semi-circumferential leading shoulders to minimize the transition between the dilator and the sheath edge, and can contain internal recesses to allow sequential retraction of segments once the introducer sheath is delivered to a target chamber. With this technology, vascular introducer sheaths can be introduced percutaneously into a broad range of diseased target vessels and chambers with reduced damage to the wall of the vessel or chamber, and with reduced damage to the distal end of the introducer sheath.
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10.发明公开DEVICE AND METHOD FOR DETECTING IRREGULAR PLACEMENT OF AN EXTRACORPOREAL VASCULAR ACCESS NEEDLE 审中-公开设备和检测方法的血管通路针张福亭不规则的定位
公开(公告)号：EP2941282A1
公开(公告)日：2015-11-11
申请号：EP14735332.0
申请日：2014-01-06
发明人： FRINAK, Stanley , ZASUWA, Gerard , YEE, Jerry , BESARAB, Anatole , KENNEDY, John B. , CURRY, Douglas S. , HIRSCHMAN, Helen Kimball
CPC分类号： A61M1/3403 , A61B5/02152 , A61B5/6866 , A61B5/7282 , A61M1/1601 , A61M1/3656 , A61M2205/3331 , A61M2205/3344 , A61M2205/52 , A61M2230/207
摘要： A device and method for determining intravascular pressure and irregular needle placement in a hemodialysis procedure include analyzing means for automatically deriving venous access pressure (VAP) at a location of venous needle insertion into the patient and determining a ratio of VAP to mean arterial pressure, where the analyzing means determines multiple VAP values over multiple time periods and determines multiple ratios, one for each VAP value. Detecting means compare each ratio to a predetermined standard ratio derived from a moving average of prior VAP ratios, where the detecting means detects irregular needle placement when elevation of the ratio above the standard ratio is indicated.
摘要翻译： 一种用于在血液透析过程中确定的采矿血管内压和不规则针放置设备和方法包括：分析装置，用于在静脉针头插入患者和确定性采矿VAP的比率的位置自动地导出静脉通路压力（VAP）对平均动脉压，其中 分析装置在多个时间段和时间确定的地雷多个比率，一个用于每个VAP值bestimmt多个VAP值。 检测装置比较每个比由现有VAP比率的移动平均值，其中当标准比率以上的比率的标高表示的检测装置检测不规则针放置衍生预定标准比率。
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