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公开(公告)号：EP1487472A2
公开(公告)日：2004-12-22
申请号：EP02797195.1
申请日：2002-12-06
申请人： FIBROGEN, INC.
发明人： GUENZLER-PUKALL, Volkmar , NEFF, Thomas, B. , WANG, Qingjian , AREND, Michael P. , FLIPPIN, Lee, A.
CPC分类号： A61K31/4745 , A61K31/00 , A61K31/17 , A61K31/4375 , A61K31/44 , A61K31/4418 , A61K31/47 , A61K31/472 , A61K31/4738 , A61K31/496 , A61K31/63 , A61K38/1709 , C07K14/4702 , C07K14/505 , G01N33/746
摘要： The present invention relates to methods of stabilizing the alpha subunit of hypoxia inducible factor (HIF). The invention further relates to methods of preventing, pretreating, or treating conditions associated with HIF, including ischemic and hypoxic conditions. Compounds for use in these methods are also provided.
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公开(公告)号：EP2298301A2
公开(公告)日：2011-03-23
申请号：EP10181796.3
申请日：2002-12-06
申请人： Fibrogen, Inc.
发明人： KLAUS, Stephen J. , LIN, Al Y. , NEFF, Thomas B. , WANG, Qingjian , GUENZLER-PUKALL, Volkmar , AREND, Michael P. , FLIPPIN, Lee A.
IPC分类号： A61K31/47 , A61K31/4738 , A61K31/63 , A61K38/17 , A61K31/00 , C07K14/47 , C07K14/505 , A61P7/06
CPC分类号： A61K31/4745 , A61K31/00 , A61K31/17 , A61K31/4375 , A61K31/44 , A61K31/4418 , A61K31/47 , A61K31/472 , A61K31/4738 , A61K31/496 , A61K31/63 , A61K38/1709 , C07K14/4702 , C07K14/505 , G01N33/746
摘要： The present invention relates to compounds for use in methods for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo . Compounds for use in methods for treating, pretreating or preconditioning, or preventing erythropoietin-associated conditions are also included.
摘要翻译： 本发明涉及用于通过在体外和体内增加内源促红细胞生成素来治疗促红细胞生成素相关病症的方法中使用的化合物。 还包括用于治疗，预处理或预处理或预防促红细胞生成素相关病症的方法的化合物。
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公开(公告)号：EP3520784A1
公开(公告)日：2019-08-07
申请号：EP19172616.5
申请日：2002-12-06
申请人： Fibrogen, Inc.
发明人： KLAUS, Stephen J. , LIN, Al Y. , NEFF, Thomas B. , WANG, Qingjian , GUENZLER-PUKALL, Volkmar , AREND, Michael P. , FLIPPIN, Lee A.
IPC分类号： A61K31/17 , A61K31/4375 , A61K31/44 , A61K31/4418 , A61K31/47 , A61K31/472 , A61K31/4738 , A61K31/4745 , A61K31/496 , A61K31/63 , C07K14/505 , A61K31/00 , C07K14/47 , G01N33/74 , A61K38/17
摘要： The present invention relates to methods for treating anemia by increasing endogenous erythropoietin via inhibition of HIF prolyl hydroxylase enzyme activity.
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公开(公告)号：EP1463823B1
公开(公告)日：2013-03-06
申请号：EP02805548.1
申请日：2002-12-06
申请人： Fibrogen, Inc.
发明人： KLAUS, Stephen, J. , LIN, Al, Y. , NEFF, Thomas, B. , WANG, Qingjian , GUENZLER-PUKALL, Volkmar , AREND, Michael, P. , FLIPPIN, Lee, A.
IPC分类号： A61K31/00 , A61K31/17 , C07K14/47 , C07K14/505 , A61K31/47 , A61K31/4738 , A61K31/63 , G01N33/74 , A61K38/17 , C12N15/09 , C12Q1/34 , C12Q1/56 , A61P7/06
CPC分类号： A61K31/4745 , A61K31/00 , A61K31/17 , A61K31/4375 , A61K31/44 , A61K31/4418 , A61K31/47 , A61K31/472 , A61K31/4738 , A61K31/496 , A61K31/63 , A61K38/1709 , C07K14/4702 , C07K14/505 , G01N33/746
摘要： The present invention relates to methods of stabilizing the alpha subunit of hypoxia inducible factor (HIF). The invention further relates to methods of preventing, pretreating, or treating conditions associated with HIF, including ischemic and hypoxic conditions. Compounds for use in these methods are also provided.
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公开(公告)号：EP2222305A1
公开(公告)日：2010-09-01
申请号：EP08845895.5
申请日：2008-11-03
申请人： Fibrogen, Inc.
IPC分类号： A61K31/472 , A61K31/437
CPC分类号： C07D471/04 , A61K31/437 , A61K31/472 , C07D217/26
摘要： The present invention provides methods and medicaments for reducing blood pressure. Methods and medicaments for treating or preventing hypertension are also provided.
摘要翻译： 本发明提供降低血压的方法和药物。 还提供了治疗或预防高血压的方法和药物。
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公开(公告)号：EP1487472B1
公开(公告)日：2019-06-26
申请号：EP02797195.1
申请日：2002-12-06
申请人： Fibrogen, Inc.
发明人： GUENZLER-PUKALL, Volkmar , NEFF, Thomas, B. , WANG, Qingjian , AREND, Michael P. , FLIPPIN, Lee, A.
IPC分类号： A61K31/44 , A61K31/4418 , A61K31/472 , A61K31/47 , A61K31/4738 , A61K31/496 , A61K31/4375 , A61K31/17 , C12N15/09 , C12Q1/56 , C12Q1/34 , A61K38/17 , A61K31/63 , A61K31/4745 , C07K14/505 , C07K14/47 , A61K38/00 , A61P9/10 , A61P1/16 , A61P11/00
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7.发明公开NITROGEN-CONTAINING HETEROARYL COMPOUNDS AND THEIR USE IN INCREASING ENDOGENEOUS ERYTHROPOIETIN 有权维他命DENEN VERWENDUNGEN ZUR ERHOEHUNG DES GEHALTES VON ENDOGENEM ERYTHROPOIETIN的STICKSTOFFHALTIGE HETEROARYHOLDBINDUNGEN
公开(公告)号：EP1644336A1
公开(公告)日：2006-04-12
申请号：EP04754384.8
申请日：2004-06-04
申请人： FIBROGEN, INC.
发明人： AREND, Michael, P. , FLIPPIN, Lee, A. , GUENZLER-PUKALL, Volkmar , HO, Wen-Bin , TURTLE, Eric, D. , DU, Xiaohui
IPC分类号： C07D217/00 , A61K31/47
CPC分类号： A61K31/472 , A61K31/4725 , A61K31/473 , A61K38/1816 , C07D217/24 , C07D217/26 , C07D221/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/12 , A61K2300/00
摘要： The present invention relates to compounds suitable for use in mediating hypoxia inducible factor and for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo.
摘要翻译： 本发明涉及适用于介导缺氧诱导因子并通过在体外和体内增加内源促红细胞生成素来治疗促红细胞生成素相关病症的化合物I。
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公开(公告)号：EP1633333A1
公开(公告)日：2006-03-15
申请号：EP04754383.0
申请日：2004-06-04
申请人： FIBROGEN, INC.
发明人： KLAUS, Stephen, J. , MOLINEAUX, Christopher, J. , NEFF, Thomas, B. , GUENZLER-PUKALL, Volkmar , LANSETMO PAROBOK, Ingrid , SEELEY, Todd, W. , STEPHENSON, Robert, C.
IPC分类号： A61K31/00 , A61K31/395 , A61K31/165 , A61P7/06
CPC分类号： C07D217/24 , A61K31/00 , A61K31/165 , A61K31/17 , A61K31/395 , A61K31/472 , C07C275/40
摘要： The present invention relates to methods and compounds for regulating or enhancing erthropoiesis and iron metabolism, and for treating or preventing iron deficiency and anemia of chronic disease.
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公开(公告)号：EP1578430A2
公开(公告)日：2005-09-28
申请号：EP03796687.6
申请日：2003-12-05
申请人： FIBROGEN, INC.
IPC分类号： A61K31/70
CPC分类号： A61K38/1709 , A61K31/00 , A61K31/437 , A61K31/44 , A61K31/4425 , A61K31/47 , A61K31/472 , A61K31/4745 , A61K31/502
摘要： The present invention relates to methods and compounds for regulating glucose metabolism, achieving glucose homeostasis, and decreasing blood glucose levels. Methods and compounds for treating or preventing diabetes, hyperglycemia, and disorders and conditions associated with altered or impaired glucose metabolism are also provided.
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公开(公告)号：EP1463823A2
公开(公告)日：2004-10-06
申请号：EP02805548.1
申请日：2002-12-06
申请人： FibroGen, Inc.
发明人： KLAUS, Stephen, J. , LIN, Al, Y. , NEFF, Thomas, B. , WANG, Qingjian , GUENZLER-PUKALL, Volkmar , AREND, Michael, P. , FLIPPIN, Lee, A.
CPC分类号： A61K31/4745 , A61K31/00 , A61K31/17 , A61K31/4375 , A61K31/44 , A61K31/4418 , A61K31/47 , A61K31/472 , A61K31/4738 , A61K31/496 , A61K31/63 , A61K38/1709 , C07K14/4702 , C07K14/505 , G01N33/746
摘要： The present invention relates to methods of stabilizing the alpha subunit of hypoxia inducible factor (HIF). The invention further relates to methods of preventing, pretreating, or treating conditions associated with HIF, including ischemic and hypoxic conditions. Compounds for use in these methods are also provided.
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