公开(公告)号：EP2326327A2

公开(公告)日：2011-06-01

申请号：EP09814892.7

申请日：2009-09-17

申请人： SRI International

发明人： JONG, Ling ,  JIANG, Faming ,  LI, Gaoquan ,  MORTELMANS, Kristien

IPC分类号： A61K31/407 ,  A61P31/04 ,  A61K31/404

CPC分类号： A61K31/407 ,  A61K31/445 ,  A61K31/497 ,  A61K31/535 ,  A61K31/551 ,  C07D487/04 ,  Y02A50/475 ,  Y02A50/481

摘要： Compounds useful as antibacterial agents are provided. The compounds are analogs of indole-3-carbinol and have a backbone selected from dihydroindolo[2,3-b]carbazole, 2,2′-diindolylmethane, 2′,3-diindolylmethane, and 3,3′-diindolylmethane. The compounds are useful therapeutic and prophylactic treatment of bacterial infections in mammals. Methods of synthesis of the compounds are provided, as are pharmaceutical compositions containing the compounds.

公开(公告)号：EP2264801A3

公开(公告)日：2011-05-04

申请号：EP10009300.4

申请日：2000-07-20

申请人： SRI International

发明人： Pelrine, Ronald ,  Kornbluh, Roy ,  Pei, Qibing ,  Oh, Seajin ,  Joseph, Jose

IPC分类号： H01L41/09 ,  H01L41/047 ,  H01L41/193 ,  H01L41/26 ,  H01L41/113 ,  F04B35/00 ,  F04B35/04 ,  F04B43/04

CPC分类号： H01L41/0536 ,  F02G2243/52 ,  F04B35/00 ,  F04B35/045 ,  F04B43/043 ,  F05C2225/08 ,  H01L41/094 ,  H01L41/0973 ,  H01L41/0986 ,  H01L41/193 ,  H01L41/45 ,  H02N2/023 ,  H04R19/02 ,  H04R23/00

摘要： Electroactive polymers that are pre-strained to improve conversion from electrical to mechanical energy are disclosed. When a voltage is applied to electrodes contacting a pre-strained polymer, the polymer deflects. This deflection may be used to do mechanical work. The pre-strain improves the mechanical response of an electroactive polymer. Furthermore, actuators including an electroactive polymer and mechanical coupling to convert deflection of the polymer into mechanical work are disclosed. Compliant electrodes that conform to the shape of a polymer are also disclosed. Methods for fabricating electromechanical devices including one or more electroactive polymers are provided.

公开(公告)号：EP2305694A2

公开(公告)日：2011-04-06

申请号：EP10177213.5

申请日：1998-12-23

申请人： SRI International

发明人： The designation of the inventor has not yet been filed

IPC分类号： C07J41/00 ,  A61K31/57 ,  C07J43/00 ,  A61K31/56 ,  A61K31/575 ,  A61K31/58 ,  A61P5/32

CPC分类号： C07J41/00 ,  A61K9/02 ,  C07J41/0072 ,  C07J41/0077 ,  C07J43/003

摘要： Novel and anti-estrogenic compounds are provided which are useful to treat a variety of disorders, particularly estrogen-dependant disorders. Preferred compounds have 1,3,5-estratiene nucleus, and are substituted at the C-17 or C-11 position with a molecular moiety which renders the compounds effective to competitively block the binding of estrogen to its receptor. Particularly preferred compounds are 17-desoxy-1,3,5-estratienes. Therapeutic methods and pharmaceutical compositions are provided as well.

摘要翻译： 提供了新颖和抗雌激素化合物，其可用于治疗多种疾病，特别是雌激素依赖性疾病。 优选的化合物具有1,3,5-雌酮核，并且在C-17或C-11位置被分子部分取代，这使得化合物有效地竞争性阻断雌激素与其受体的结合。 特别优选的化合物是17-脱氧-1,3,5-雌酮。 也提供治疗方法和药物组合物。

公开(公告)号：EP2286729A2

公开(公告)日：2011-02-23

申请号：EP10191613.8

申请日：1996-06-05

申请人： SRI International

发明人： Jensen, Joel F. ,  Hill, John W.

IPC分类号： A61B17/00 ,  A61B19/00

CPC分类号： A61B17/29 ,  A61B34/30 ,  A61B34/35 ,  A61B34/70 ,  A61B34/71 ,  A61B34/76 ,  A61B2017/00367 ,  A61B2017/00464 ,  A61B2017/00477 ,  A61B2017/2902 ,  A61B2017/292 ,  A61B2034/305 ,  A61B2090/506 ,  B25J9/1065 ,  B25J15/04 ,  B25J18/04

摘要： The invention is directed to manipulator assembly (2) for holding and manipulating a surgical instrument (14) in a telerobotic system. The manipulator assembly includes an instrument holder removably coupled to a drive assembly so that the holder can be sterilized. The assembly further includes a force sensing element (52) mounted distal to the holder and the drive assembly for detecting forces exerted on the surgical instrument and providing feedback to the surgeon. The invention is also directed to a system and method for releasably holding a surgical instrument (14). The system includes an instrument support for automatically locking mounting pins on the instrument within locking slots on the instrument holder to releasably couple the instrument to the holder. With a twist-lock motion, the surgeon can rapidly engage and disengage various instruments from the holder during a surgical procedure, such as open surgery, laparoscopy or thoracoscopy.

摘要翻译： 本发明涉及用于在远程操作系统中保持和操纵外科器械（14）的操纵器组件（2）。 操纵器组件包括可移除地联接到驱动组件的仪器保持器，使得保持器可以被消毒。 组件还包括安装在保持器的远侧的力感测元件（52）和用于检测施加在外科器械上的力并向外科医生提供反馈的驱动组件。 本发明还涉及一种用于可释放地保持外科器械（14）的系统和方法。 该系统包括一个仪器支架，用于将仪器上的安装销自动锁定在仪器架上的锁定槽内，以将仪器可释放地连接到支架上。 通过扭锁运动，外科医生可以在手术过程（例如开放手术，腹腔镜检查或胸腔镜检查）中快速地将各种器械从保持器接合和脱离。

公开(公告)号：EP2271260A2

公开(公告)日：2011-01-12

申请号：EP09739999.2

申请日：2009-05-02

申请人： SRI International

发明人： VESTEL, Michael, J. ,  NASHOLD, Karen, M. ,  STETTER, Joseph, R. ,  WALTER, Diane, P. ,  FARIS, Gregory, W. ,  HOLLAND, Christopher ,  SCHMIDT, Roger

IPC分类号： A61B5/145 ,  A61B5/1455 ,  A61B5/1477 ,  G05F1/00

CPC分类号： A61B5/1459 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/6833 ,  A61B5/6849 ,  A61B2562/028

摘要： Optical microneedles are adapted for near-infrared or mid-infrared in vivo spectroscopic sensing; and provide a MEMS-based spectrometer for continuous lactate and glucose monitoring by means of a near-infrared or mid-infrared optical microneedle array in a transdermal patch.

公开(公告)号：EP1221180B1

公开(公告)日：2010-09-08

申请号：EP00959149.6

申请日：2000-07-20

申请人： SRI International

发明人： PELRINE, Ronald, E. ,  KORNBLUH, Roy, D. ,  PEI, Qibing ,  OH, Seajin ,  JOSEPH, Jose, P.

IPC分类号： H01L41/09 ,  H01L41/26

CPC分类号： H01L41/0536 ,  F02G2243/52 ,  F04B35/00 ,  F04B35/045 ,  F04B43/043 ,  F05C2225/08 ,  H01L41/094 ,  H01L41/0973 ,  H01L41/0986 ,  H01L41/193 ,  H01L41/45 ,  H02N2/023 ,  H04R19/02 ,  H04R23/00

摘要： The present invention relates to electroactive polymers (152) that are pre-strained to improve conversion from electrical to mechanical energy. When a voltage is applied to electrodes (156) contacting a pre-strained polymer (152), the polymer (152) deflects. This deflection may be used to do mechanical work. The pre-strain improves the mechanical response of an electroactive polymer (152). The present invention also relates to actuators including an electroactive polymer and mechanical coupling to convert deflection of the polymer into mechanical work. The present invention further relates to compliant electrodes that conform to the shape of a polymer. The present invention provides methods for fabrication electromechanical devices including one or more electroactive polymers.

公开(公告)号：EP2212954A1

公开(公告)日：2010-08-04

申请号：EP08836558.0

申请日：2008-10-03

申请人： SRI International

发明人： CARDENAS-VALENCIA, Andres, M. ,  ADORNATO, Lori ,  SHORT, Robert, T. ,  LANGEBRAKE, Larry, C. ,  CROUCH-BAKER, Steven

IPC分类号： H01M6/32 ,  H01M16/00

CPC分类号： H01M6/34 ,  H01M6/24 ,  H01M6/32 ,  H01M16/003

摘要： In one embodiment, the present invention relates generally to a method and system for providing a flow through battery cell and uses thereof. In one embodiment, the flow through battery cell includes an inlet for receiving a flow of water, a solid oxidizer coupled to said inlet for reacting with said flow of water to generate a catholyte, wherein the solid oxidizer comprises at least one of: an organic halamine, a succinimide or a hypochlorite salt, a galvanic module coupled to the solid oxidizer for receiving the catholyte and generating one or more effluents and an outlet for releasing the one or more effluents.

公开(公告)号：EP1481467B1

公开(公告)日：2010-06-09

申请号：EP03719361.2

申请日：2003-03-05

申请人： SRI International

发明人： HEIM, Jonathon, R. ,  PELRINE, Ronald, E. ,  KORNBLUH, Roy, David ,  ECKERLE, Joseph S. ,  ROSENTHAL, Marcus ,  HEYDT, Richard, P.

IPC分类号： H02N1/00 ,  H01L41/09 ,  H01L41/16 ,  F04B35/00 ,  F04B43/04

CPC分类号： F04B35/00 ,  A61M5/142 ,  A61M5/14276 ,  F01L1/46 ,  F01L7/02 ,  F01L9/04 ,  F01L2101/00 ,  F04B43/043 ,  F15D1/025 ,  F15D1/065

公开(公告)号：EP2179460A1

公开(公告)日：2010-04-28

申请号：EP08795577.9

申请日：2008-08-25

申请人： SRI International

发明人： SHI, Yijian

IPC分类号： H01L51/52 ,  H01L51/54

CPC分类号： H01L51/0094 ,  H01L51/0077 ,  H01L51/102 ,  H01L51/5092 ,  H01L51/5221

摘要： The disclosure provides methods, materials, and devices suitable for use in electroluminescent devices. In one embodiment, for example, there is provided a layered cathode comprising a metal substrate and an intermediate organic or organometallic layer having an electron accepting group. The intermediate layer provides an interface with an overlaying electroluminescent layer. The disclosure finds utility, for example, in the field of microelectronic devices.

公开(公告)号：EP2135561A3

公开(公告)日：2010-02-17

申请号：EP09172375.9

申请日：1996-06-05

申请人： SRI International

发明人： Jensen, Joel F. ,  Hill, John W.

IPC分类号： A61B17/00 ,  A61B19/00

CPC分类号： A61B17/29 ,  A61B34/30 ,  A61B34/35 ,  A61B34/70 ,  A61B34/71 ,  A61B34/76 ,  A61B2017/00367 ,  A61B2017/00464 ,  A61B2017/00477 ,  A61B2017/2902 ,  A61B2017/292 ,  A61B2034/305 ,  A61B2090/506 ,  B25J9/1065 ,  B25J15/04 ,  B25J18/04

摘要： A surgical system and surgical instruments for a telerobitic system are disclosed. In one embodiment, the surgical instrument has an elongate shaft having a proximal portion, a distal portion, an inner lumen, and at least one axially extending slot. An end effector is disposed adjacent the distal portion of the elongate shaft and an actuator assembly, comprising a linkage, is disposed within the inner lumen. A movable actuator pin extends laterally from the linkage and through the axially extending slot to releasably couple the actuator assembly to a driver of a robotic surgical instrument holder. The system disclosed may enable the rapid engagement and disengagement of surgical instruments from an instrument holder during surgical procedures.