利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

282 条记录 (耗时 0.027 秒)

    Pharmaceutical compositions containing ascomycin derivatives
    32.
    发明公开
    Pharmaceutical compositions containing ascomycin derivatives 失效
    Arzneizusammensetzungen enthaltend Ascomycinderivate

    公开(公告)号：EP1273289A1

    公开(公告)日：2003-01-08

    申请号：EP02022257.6

    申请日：1997-01-20

    申请人： Novartis AG ,  Novartis Erfindungen Verwaltungsgesellschaft M.B.H.

    发明人： Tiemessen, Harry

    IPC分类号： A61K9/107 ,  A61K47/10 ,  A61K47/12 ,  A61K47/24 ,  A61K47/00 ,  A61K31/435

    CPC分类号： A61K47/12 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/1075 ,  A61K31/435 ,  A61K31/4353 ,  A61K31/436 ,  A61K47/10 ,  A61K47/24

    摘要： A process for preparing an emulsion composition comprising an ascomycin or a derivative thereof as active agent, which process comprises the step of admixing to a placebo fat emulsion a concentrate comprising

    a) the active agent,
    b) a stabiliser selected from a phospholipid, a glycolipid, a sphingolipid, a diacylphosphatidyl glycerol, an egg-phosphatidylglycerol, a soy-phosphatidylglycerol, or a salt thereof; or a saturated, mono- or di-unsaturated (C 12-24 ) fatty acid, or a salt thereof, and
    c) an organic solvent,
       wherein the weight ratio of acitve agent to stabiliser is between 400:1 and 0.5:1.
    The invention also provides ready-to-use emulsions, e.g. for intravenous administration, prepared using the above process.

    摘要翻译： 一种制备包含雷帕霉素或其衍生物作为活性剂的乳剂组合物的方法，该方法包括将包含a）活性剂的浓缩物与b的稳定剂混合，所述浓缩物包含：磷脂，糖脂， 鞘脂，二酰基磷脂酰甘油，卵磷脂酰甘油，大豆磷脂酰甘油或其盐; 或饱和的单或二不饱和（C12-24）脂肪酸或其盐，和c）有机溶剂，其中助剂与稳定剂的重量比为400:1至0.5:1。 本发明还提供即用​​型乳剂，例如， 用于静脉内给药，使用上述方法制备。

    8-QUINOLINXANTHINE AND 8-ISOQUINOLINXANTHINE DERIVATIVES AS PDE 5 INHIBITORS
    33.
    发明公开
    8-QUINOLINXANTHINE AND 8-ISOQUINOLINXANTHINE DERIVATIVES AS PDE 5 INHIBITORS 有权
    8-CHINOLINXANTHIN和8-异辛酰吗啉衍生物ALS PDE 5抑制剂

    公开(公告)号：EP1268480A1

    公开(公告)日：2003-01-02

    申请号：EP01940294.0

    申请日：2001-04-05

    申请人： Novartis AG ,  Novartis-Erfindungen Verwaltungsgesellschaft m.b.H.

    发明人： BHALAY, Gurdip ,  COLLINGWOOD, Stephen Paul ,  FAIRHURST, Robin Alec ,  GOMEZ, Sylvie, Felicite ,  NAEF, Reto ,  SANDHAM, David, Andrew

    IPC分类号： C07D473/06 ,  C07D239/54 ,  A61K31/52 ,  A61P15/00

    CPC分类号： C07D239/545 ,  C07D473/06

    摘要： A compound of formula (I) in free or salt form, where R1 is hydrogen or alkyl optionally substituted by hydroxy, alkoxy, or alkylthio, R2 is hydrogen, alkyl, hydroxyalkyl, alkylcarbonyloxyalkyl, alkoxyalkyl, alkylthioalkyl, alkenyl, cycloalkylalkyl, heterocyclylalkyl, aralkyl in which the aryl ring thereof is optionally fused to a 5-membered heterocyclic group or is optionally substituted by one or more substituents selected from alkoxy, amino, alkylamino, dialkylamino, acylamino, halogen, hydroxy, aminosulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl, alkylsulfonylamino or dialkylaminosulfonylamino, R3 is hydrogen or alkyl optionally substituted by hydroxy, alkoxy, or alkylthio, R4 is hydrogen or alkyl, R5 is a quinolinyl, isoquinolinyl or oxodihydroisoquinolinyl group optionally fused to a 5-membered heterocyclic group and optionally substituted by one or more substituents selected from halogen, cyano, hydroxy, alkyl, hydroxyalkyl, alkoxyalkyl, alkylthioalkyl, alkoxy, alkylthio, alkenyl, alkoxycarbonyl, alkynyl, carboxyl, acyl, a group of formula -N(R6)R7, aryl optionally substituted by one or more substituents selected from halogen or alkoxy, or heteroaryl having 5 or 6 ring atoms attached through a ring carbon atom to the indicated carbon atom, and R?6 and R7¿ are each independently hydrogen or alkyl optionally substituted by hydroxy or alkoxy or one of R?6 and R7¿ is hydrogen and the other is acyl, or R?6 and R7¿ together with the nitrogen atom to which they are attached denote a 5- or 6- membered heterocyclyl group.

    System and method for treating articles like ophthalmic lenses, contact lenses or medical devices with fluids
    34.
    发明公开
    System and method for treating articles like ophthalmic lenses, contact lenses or medical devices with fluids 有权
    装置和方法用于治疗例如眼科镜片，隐形眼镜，或与液体的医疗设备的文章

    公开(公告)号：EP1262306A1

    公开(公告)日：2002-12-04

    申请号：EP02011294.2

    申请日：2002-05-22

    申请人： Novartis AG ,  Novartis-Erfindungen Verwaltungsgesellschaft m.b.H.

    发明人： Gilliard, Allen ,  Janssen, Robert Allen

    IPC分类号： B29D11/00 ,  G02B1/10 ,  B08B3/04

    CPC分类号： G02B1/10 ,  A61L2/18 ,  A61L2/26 ,  A61L12/08 ,  A61L12/086 ,  A61L2202/24 ,  B08B3/102 ,  B08B3/108 ,  B08B11/02 ,  B29D11/00067

    摘要： The present invention provides a method for efficiently and uniformly treating articles with two or more fluids without transferring the articles from one container to another container. The method comprises: providing the fluids, one at a time, to treat the articles (10) in a treatment system, wherein the treatment system comprises one or more trays (20) each of which has one or more baskets, each basket capable of holding one article (10), and wherein said trays (20) are stacked to form a vessel or are stacked and placed within a preformed vessel (140), said vessel or preformed vessel comprising a first entrance/exit (45,145) and a second entrance/exit (55,155)for the fluids; and each time one of the fluids is provided to treat the articles, (a) flushing continuously the articles with the fluid in a first flow direction from the first entrance/exit to the second entrance/exit, (b) reversing the flow direction of the fluid, (c) flushing continuously the articles with the fluid in a second direction from the second entrance/exit to the first entrance/exit for a second period of time, and (d) if necessary, repeating steps (a) to (c) for a desired number of times.

    摘要翻译： 本发明提供用于与两种或多种流体有效且均匀地处理制品，而不传递环的物品从一个容器到另一个容器的方法。 该方法包括：提供所述流体，一次一个，以治疗在治疗系统中的物品（10），worin该处理系统包括一个或多个托盘（20）的每一个具有一个或多个笼中，每个笼能够 保持一个物品（10），和worin所述托盘（20）被堆叠以形成容器或堆叠并预成型的容器（140），所述容器内放置或预先形成的容器，其包括第一入口/出口（45.145）和第二 用于流体的入口/出口（55.155）; 每一次流体中的一种，提供了治疗的文章中，（a）从第一入口/出口冲洗持续地与流体的物品在第一流动方向上与第二入口/出口，（b）中翻转的流动方向 流体，（c）从第二入口/出口连续冲洗用流体制品的第二方向至所述第一入口/出口对的第二时间段，以及（d）如果需要，重复步骤（a）至（ C）为期望的次数。

    BORONIC COMPOUND COMPLEXING REAGENTS AND HIGHLY STABLE COMPLEXES
    38.
    发明授权
    BORONIC COMPOUND COMPLEXING REAGENTS AND HIGHLY STABLE COMPLEXES 失效
    复合状况FOR硼化合物和高稳定的复合物

    公开(公告)号：EP0915832B1

    公开(公告)日：2002-10-02

    申请号：EP97935178.0

    申请日：1997-07-24

    申请人： PROLINX, INC.

    发明人： STOLOWITZ, Mark, L. ,  KAISER, Robert, J. ,  LUND, Kevin, P.

    IPC分类号： C07C233/49 ,  G01N33/53 ,  C07C259/10 ,  C07F5/02

    CPC分类号： C07C237/22 ,  C07C229/38 ,  C07C233/49 ,  C07C255/13 ,  C07C259/10 ,  C07C271/22 ,  C07C281/02 ,  G01N33/54353

    摘要： Boron compound complexing reagents, intermediate reagents of those reagents and methods of synthesizing these reagents are disclosed. These reagents, including those shown as General Formula (I) and General Formula (II) may be used, after further reactions described herein, to complex with boronic compounds, such as phenylboronic acid or derivatives thereof. Boron compound complexing reagents, boron compound complexes, and methods of synthesizing these reagents and complexes are disclosed. These reagents and complexes include those shown in General Formula (CIII), General formula (CIV), and General Formula (CVI). In one embodiment, the reagents of General formula (CIII) may be used to produce, after condensation with a bioactive species (BAS), the reagent of General Formula (CIV). The reagent of General Formula (CIV) may be used to form a complex with a boron compound, such as a complex shown in General Formula (CVI).

    COATING OF TABLET CORES
    40.
    发明公开
    COATING OF TABLET CORES 无效
    片剂包衣种子的

    公开(公告)号：EP1231903A2

    公开(公告)日：2002-08-21

    申请号：EP00987277.1

    申请日：2000-11-21

    申请人： BIOCHEMIE GESELLSCHAFT M.B.H.

    发明人： ENTNER, Reinhard ,  JENNEWEIN, Herwig

    IPC分类号： A61K9/34 ,  A61K9/36

    CPC分类号： A61K9/286 ,  A61K9/2813 ,  A61K9/2826

    摘要： A process for the coating of tablet cores, said tablet core comprising an effective amount of at least one pharmaceutically active compound, comprising spraying a coating solution or suspension comprising a sugar, or a starch, or a mixture of a sugar and a starch onto the tablets or tablet cores with the proviso that film-forming agents in the coating solution or suspension are excluded, to obtain coated tablets, such coated tablets and corresponding coating mixtures.