公开(公告)号：EP2937356A1

公开(公告)日：2015-10-28

申请号：EP15158675.7

申请日：2008-07-30

申请人： Cipla Limited

发明人： Phull, Manjinder Singh ,  Kankan, Rajendra Narayanrao ,  Rao, Dharmaraj Ramachandra

IPC分类号： C07F9/6561

CPC分类号： C07F9/65616

摘要： Crystalline Form C of tenofovir disoproxil.

摘要翻译： 替诺福韦的晶形C的。

公开(公告)号：EP2921503A1

公开(公告)日：2015-09-23

申请号：EP13855456.3

申请日：2013-11-07

申请人： Shanghai Serum Biotechnology Co., Ltd. ,  Institute of Biotechnology, Academy of Military Medical Sciences, Pla.

发明人： SUN, Zhiwei ,  WANG, Shuang ,  SUN, Jiuru ,  ZHANG, Chang ,  QIU, Weiyi ,  FAN, Tiejiong

IPC分类号： C07K16/28 ,  C07K19/00 ,  C12N15/13 ,  C12N15/63 ,  C12N1/15 ,  C12N1/21 ,  C12N5/10 ,  G01N33/53 ,  C07K1/22 ,  A61K39/395 ,  A61P35/00 ,  A61P29/00 ,  A61P37/02

CPC分类号： C07K16/2863 ,  A61K39/39558 ,  A61K47/6849 ,  A61K47/6851 ,  A61K2039/505 ,  C07K1/22 ,  C07K16/30 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/55 ,  C12N15/1037

摘要： The present invention provides human anti-human epidermal growth factor receptor (EGFR) antibodies and their encoding genes and applications thereof. By gene engineering means and phage surface display technology, the present invention screens anti-human EGFR gene engineering single chain antibody from fully synthetic single chain human antibody library, and obtains the antibody variable gene sequence thereof, and based thereon, constructs intact human monoclonal antibody, to further obtain high-purity antibody protein. The binding affinity of the antibody of the present invention with human EGFR is no more than 1 nM, and the mutants affinity thereof is no more than 10 nM; and the identification of the immunity activity and bioactivity of antibodies protein IgG is completed, confirming that the antibody of the present invention has good bioactivity of inhibiting the tumor growth of EGFR expressing cell A431 tumor-bearing model mouse. The antibodies of the present invention provides specific antibody drugs for preventing and treating EGFR targeted tumor and other diseases such as inflammation and autoimmune diseases.

摘要翻译： 本发明提供了人抗 - 人表皮生长因子受体（EGFR）抗体及其编码基因和它们的应用程序。 通过基因工程手段与噬菌体表面展示技术，本发明的屏幕的抗人EGFR基因工程从完全合成的单链人抗体文库的单链抗体，并且获得其抗体可变基因序列，并且基于此，构建完整的人单克隆抗体 ，つweiterer获得高纯度的抗体蛋白。 与人类EGFR本发明的抗体的结合亲和力是不大于1nM的更多，并且它们的突变体的亲和力是不超过10纳米; 和免疫活性和抗体的IgG蛋白的生物活性的鉴定完毕，确认做了本发明的抗体具有EGFR表达细胞A431荷瘤小鼠模型中的肿瘤生长的良好的生物活性抑制。 本发明的抗体提供特定抗体的药物用于预防和治疗EGFR靶向的肿瘤和其他疾病：如炎症和自身免疫性疾病。

公开(公告)号：EP2910543A1

公开(公告)日：2015-08-26

申请号：EP13849534.6

申请日：2013-10-22

申请人： CJ Cheiljedang Corporation

发明人： GWAK, Won Sik ,  SEO, Yong Bum ,  LEE, Chong Ho ,  LEE, In Sung ,  MURATA, Hideki

IPC分类号： C07C209/84 ,  C07C211/09 ,  C08G69/04

CPC分类号： C07C209/84 ,  C07C211/09 ,  C08G69/26 ,  C12P13/001

摘要： A purification method of 1,4-diaminobutane, 1,4-diaminobutane purified using the purification method, and a polyamide prepared using the purified 1,4-diaminobutane are provided. The purification method of 1,4-diaminobutane includes: concentrating a fermentation solution including at least one of 1,4-diaminobutane and a salt thereof to obtain a concentrate; adding a base to the concentrate of the fermentation solution to prepare an basic composition having a pH 12 or higher; and recovering 1,4-diaminobutane from the basic composition.

摘要翻译： 的1,4- diaminobutanes的纯化方法，1,4- diaminobutanes使用的纯化方法进行纯化，并使用设置在纯化的1,4- diaminobutanes制备的聚酰胺。 的1,4- diaminobutanes的纯化方法包括：浓缩的发酵液包括1,4- diaminobutanes的至少一个和它们的盐，以获得浓缩物; 将碱加入到所述发酵液的浓缩物，以制备具有pH为12或更高的碱性组合物; 并从该基本组成1,4- diaminobutanes。

公开(公告)号：EP2909285A1

公开(公告)日：2015-08-26

申请号：EP13847276.6

申请日：2013-10-11

申请人： Halliburton Energy Services, Inc.

发明人： REDDY, B. Raghava ,  CHUNG, Hsin Chen ,  LUBIS, Wirdansyah

IPC分类号： C09K8/58 ,  C09K8/42 ,  C09K8/50

CPC分类号： E21B43/16 ,  C09K8/502 ,  C09K8/514 ,  E21B21/003

摘要： Additives are used in treatment fluids in subterranean operations to prevent fluid loss within a subterranean formation. A method includes providing a treatment fluid that includes a viscosifying polymer and a solid-liquid phase transition temperature modifier and placing the treatment fluid in a subterranean formation penetrated by a wellbore, wherein the solid-liquid phase temperature modifier is added in an amount to modulate the gelling temperature of the viscosifying polymer to a target temperature.

公开(公告)号：EP2900786A1

公开(公告)日：2015-08-05

申请号：EP13841705.0

申请日：2013-09-27

申请人： Halliburton Energy Services, Inc.

发明人： LENDE, Gunnar ,  KARCHER, Jeffrey, Wayne

IPC分类号： C09K8/40 ,  E21B33/13

CPC分类号： C04B28/18 ,  C04B28/182 ,  C09K8/424 ,  C04B14/16 ,  C04B2103/12

摘要： Methods and compositions for the treatment of subterranean formations, and more specifically, treatment fluids containing pumicite and methods of using these treatment fluids in subterranean formations, are provided. An example of a method is a method of displacing a fluid in a well bore. Another example of a method is a method of separating fluids in a well bore in a subterranean formation. An example of a composition is a settable spacer fluid comprising pumicite, an activating agent, and a base fluid.

公开(公告)号：EP2841925A1

公开(公告)日：2015-03-04

申请号：EP13719654.9

申请日：2013-04-11

申请人： Halliburton Energy Services, Inc.

发明人： FREESE, Robert ,  JONES, Christopher Michael ,  PERKINS, David ,  SIMCOCK, Michael ,  SOLTMANN, William

IPC分类号： G01N21/31 ,  G01J3/02 ,  G06E3/00

CPC分类号： G01N21/17 ,  G01J2003/1213 ,  G01J2003/1226 ,  G01N21/31 ,  G02B27/1006 ,  G02B27/141 ,  G06E3/001

摘要： Optical computing devices are disclosed. One exemplary optical computing device includes an electromagnetic radiation source configured to optically interact with a sample and at least two integrated computational elements. The at least two integrated computational elements are configured to produce optically interacted light and further configured to be associated with a characteristic of the sample. The optical computing device further includes a first detector arranged to receive the optically interacted light from the at least two integrated computational elements and thereby generate a first signal corresponding to the characteristic of the sample.

摘要翻译： 公开了光学计算设备。 一个示例性光学计算设备包括被配置为与样本和至少两个集成的计算元件光学相互作用的电磁辐射源。 所述至少两个集成的计算元件被配置为产生光学相互作用的光，并进一步被配置成与样本的特征相关联。 光学计算设备还包括第一检测器，其布置成接收来自至少两个集成的计算元件的光学相互作用的光，从而产生对应于样本的特性的第一信号。

公开(公告)号：EP2841890A1

公开(公告)日：2015-03-04

申请号：EP13717681.4

申请日：2013-04-08

申请人： Halliburton Energy Services, Inc.

发明人： FREESE, Robert ,  JONES, Christopher, Michael ,  PERKINS, David ,  SIMCOCK, Michael ,  SOLTMANN, William

IPC分类号： G01J3/02 ,  G01N21/31 ,  G06E3/00

CPC分类号： G01N21/17 ,  G01J3/0232 ,  G01J3/36 ,  G01J3/42 ,  G01J2003/1213 ,  G01N21/31 ,  G06E3/001

摘要： Optical computing devices are disclosed. One exemplary optical computing device (300) includes an electromagnetic radiation source (308) configured to optically interact with a sample (306) and at least two integrated computational elements (302, 304). The at least two integrated computational elements are configured to produce optically interacted light (314), and at least one of the at least two integrated computational elements is configured to be disassociated with a characteristic of the sample. The optical computing device further includes a first detector (316) arranged to receive the optically interacted light from the at least two integrated computational elements and thereby generate a first signal corresponding to the characteristic of the sample.

公开(公告)号：EP2841523A1

公开(公告)日：2015-03-04

申请号：EP13720729.6

申请日：2013-04-26

申请人： Halliburton Energy Services, Inc.

发明人： THAEMLITZ, Carl, J. ,  RODDY, Craig, W. ,  COVINGTON, Ricky, L. ,  CHATTERJI, Jiten ,  BRENNEIS, D.. Chad

IPC分类号： C09K8/03 ,  C09K8/502 ,  C09K8/504 ,  C09K8/516 ,  C04B20/00 ,  C04B28/00 ,  C09K8/46 ,  C09K8/48 ,  C09K8/487

CPC分类号： C09K8/032 ,  B82Y30/00 ,  C04B28/02 ,  C04B2111/00008 ,  C09K8/46 ,  C09K8/502 ,  C09K8/5045 ,  C09K8/516 ,  C09K2208/10 ,  C04B14/06 ,  C04B20/008

摘要： Disclosed embodiments relate to well treatment fluids and methods that utilize nano-particles. Exemplary nano-particles are selected from the group consisting of particulate nano-silica, nano-alumina, nano-zinc oxide, nano-boron, nano-iron oxide, and combinations thereof. Embodiments also relate to methods of cementing that include the use of nano-particles. An exemplary method of cementing comprises introducing a cement composition into a subterranean formation, wherein the cement composition comprises cement, water and a particulate nano-silica. Embodiments also relate to use of nano-particles in drilling fluids, completion fluids, simulation fluids, and well clean-up fluids.

公开(公告)号：EP2828350A1

公开(公告)日：2015-01-28

申请号：EP13702720.7

申请日：2013-01-25

申请人： Halliburton Energy Services, Inc.

发明人： LIVANEC, Philip Wayne ,  MILLER, Matthew Lynn

IPC分类号： C09K8/516 ,  C09K8/03 ,  C09K8/487

CPC分类号： C09K8/516 ,  C09K8/03 ,  C09K8/487

摘要： A method of servicing a wellbore in contact with a subterranean formation, comprising placing a wellbore servicing fluid comprising a drilling fluid and lost circulation material into a lost circulation zone within the wellbore, wherein the lost circulation material comprises a polyelectrolyte multilayer material and a first counterion. A wellbore servicing fluid comprising a drilling fluid and a lost circulation material comprising a polyelectrolyte multilayer material and a counterion comprising a halide, wherein the LCM has a first state that is hydrophilic. A tunable lost circulation material comprising a base material, a polyelectrolyte multilayer on said base material, wherein the polyelectrolyte multilayer comprises a first electrolyte layer, a second electrolyte layer, and a charged surface, and a counterion, wherein wettability of the lost circulation material is a function of the counterion.

公开(公告)号：EP2814827A1

公开(公告)日：2014-12-24

申请号：EP13704817.9

申请日：2013-02-08

申请人： Hovione International Ltd.

发明人： SOBRAL, Luis ,  TEMTEM Marcio ,  ANTUNES, Rafael ,  NUNES, Bruna

IPC分类号： C07D451/10

CPC分类号： C07D451/14 ,  C07D451/10

摘要： The present invention relates to a novel process for the preparation of tiotropium bromide there is provided a process for preparing tiotropium bromide comprising (i) reacting scopine oxalate with diethylamine in an inert solvent to form scopine; (ii) reacting scopine and methyl di-(2-dithienyl)glycoIate (MDTG) in the presence of an inorganic base, and in an inert solvent to form N-demethyltiotropium; (iii) reacting N-demethyltiotropium with bromomethane in an inert solvent to form tiotropium bromide; (iv) crystallizing tiotropium bromide in a mixture of methanol and acetone, and optionally thereafter, (v) micronizing the tiotropium bromide so formed.