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    IMMUNOMODULATORY PROPERTIES OF MULTIPOTENT ADULT PROGENITOR CELLS AND USES THEREOF
    31.
    发明公开
    IMMUNOMODULATORY PROPERTIES OF MULTIPOTENT ADULT PROGENITOR CELLS AND USES THEREOF 审中-公开
    免疫调节剂EIGENSCHAFTEN VON MULTIPOTENTEN ADULTENVORLÄUFERZELLENUND IHRE VERWENDUNG

    公开(公告)号：EP1951294A1

    公开(公告)日：2008-08-06

    申请号：EP06837336.4

    申请日：2006-11-09

    申请人： Athersys, Inc. ,  OREGON HEALTH SCIENCE UNIVERSITY

    发明人： DEANS, Robert ,  VAN'T HOF, Wouter ,  MAZIARZ, Richard ,  KOVACSOVICS, Magdalena ,  STREETER, Philip

    IPC分类号： A61K39/00 ,  A61K35/28 ,  A61P37/06

    摘要： Isolated cells are described that are not embryonic stem cells, not embryonic germ cells, and not germ cells. The cells can differentiate into at least one cell type of each of at least two of the endodermal, ectodermal, and mesodermal lineages. The cells do not provoke a harmful immune response. The cells can modulate immune responses. As an example, the cells can suppress an immune response in a host engendered by allogeneic cells, tissues, and organs. Methods are described for using the cells, by themselves or adjunctively, to treat subjects. For instance, the cells can be used adjunctively for immunosuppression in transplant therapy. Methods for obtaining the cells and compositions for using them also are described.

    摘要翻译： 描述了不是胚胎干细胞，而不是胚胎生殖细胞，而不是生殖细胞的分离的细胞。 细胞可以分化为至少两种内胚层，外胚层和中胚层谱系中的至少一种细胞类型。 细胞不会引起有害的免疫反应。 细胞可以调节免疫反应。 作为示例，细胞可以抑制由同种异体细胞，组织和器官产生的宿主中的免疫应答。 描述了使用细胞本身或辅助地治疗受试者的方法。 例如，细胞可以辅助地用于移植治疗中的免疫抑制。 还描述了获得细胞和使用它们的组合物的方法。

    METHODS FOR USING ADAMTS-12, AN INTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS
    34.
    发明公开
    METHODS FOR USING ADAMTS-12, AN INTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS 审中-公开
    使用方法ADAMTS-12，一种整和金属蛋白酶凝血酶敏感动机的

    公开(公告)号：EP1531716A2

    公开(公告)日：2005-05-25

    申请号：EP03734487.6

    申请日：2003-06-06

    申请人： Athersys, Inc.

    发明人： JACKSON, Paul, David ,  TING, Anthony, Eugene ,  FABER, Pieter, W.

    IPC分类号： A61B1/00

    CPC分类号： G01N33/5011 ,  C12N9/6489 ,  C12Q1/37 ,  G01N33/5088 ,  G01N2333/8146 ,  G01N2500/00

    摘要： The present invention relates to methods for using a human A Disintegrin And Metalloprotease containing ThromboSpondin repeats (ADAM-TS). The invention also relates to methods for using polynucleotides encoding the metalloprotease. The invention relates to methods using the ADAM-TS polypeptides and polynucleotides as a target for diagnosis and treatment in metalloprotease-mediated or -related disorders. The invention further relates to drug-screening method using the ADAM-TS polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the ADAM-TS polypeptides and polynucleotides. The invention further relates to antagonists identified by drug screening methods with the ADAM-TS polypeptides and polynucleotides as a target. The invention further related to methods of treating a subject suffering from a ADAM-TS associated disorder.