公开(公告)号：EP4408390A2

公开(公告)日：2024-08-07

申请号：EP22789231.2

申请日：2022-09-27

Applicant: King's College Hospital NHS Foundation Trust

Inventor： DHAWAN, Anil ,  FILIPPI, Celine

IPC: A61K9/00 ,  A61K9/50 ,  A61K35/28 ,  A61K35/407 ,  A61P1/16

CPC classification number: A61K9/5036 ,  A61K9/0019 ,  A61K9/0024 ,  A61P1/16 ,  A61K35/407 ,  A61K35/28

公开(公告)号：EP3401392A1

公开(公告)日：2018-11-14

申请号：EP17736049.2

申请日：2017-01-06

Applicant: National Cancer Center Japan ,  Cynity Co., Ltd

Inventor： OCHIYA, Takahiro ,  KATSUDA, Takeshi

IPC: C12N5/0735 ,  A61K35/407 ,  A61P1/16 ,  C12N5/077 ,  C12Q1/02

CPC classification number: A61K35/407 ,  C12Q1/02

Abstract: The present invention provides a method for producing hepatic stem/progenitor cells from mammal hepatocytes, comprising bringing a TGFβ-receptor inhibitor, and optionally a GSK3 inhibitor and/or a ROCK inhibitor into contact with the hepatocytes in vitro.

公开(公告)号：EP3220925A4

公开(公告)日：2018-07-18

申请号：EP15852175

申请日：2015-10-21

Applicant: INDIANA UNIV RESEARCH & TECHNOLOGY CORPORATION

Inventor： TECTOR JOSEPH A

IPC: A61K35/12 ,  A01K67/027 ,  A61K35/22 ,  A61K35/407

CPC classification number: A01K67/0276 ,  A01K2217/075 ,  A01K2217/15 ,  A01K2227/108 ,  A01K2267/025 ,  A61K35/12 ,  A61K35/22 ,  A61K35/407 ,  C12N2517/02

Abstract: The application provides methods of improving a rejection related symptom, reducing premature separation and methods of producing a compound of interest with an altered epitope profile are provided. Knockout pigs with a disrupted gene or genes, and porcine organs, tissues, and cells therefrom are provided.

公开(公告)号：EP3332798A1

公开(公告)日：2018-06-13

申请号：EP17210060.4

申请日：2011-08-30

Applicant: Generon (Shanghai) Corporation Ltd.

Inventor： YAN, Xiaoqiang ,  HUANG, Zhihua ,  YANG, Hongzhou ,  HUANG, Yuliang

IPC: A61K38/20 ,  A61P31/12 ,  A61P1/16 ,  C07K14/54

CPC classification number: A61K38/20 ,  A61K35/407 ,  C07K14/54 ,  Y02A50/463 ,  Y10S514/883

Abstract: This invention relates to a use of IL-22 in the treatment of viral hepatitis. As illustrated in the examples of this invention, IL-22 can significantly reduce liver damage caused by hepatitis virus, and can significantly reduce the increase of transaminase ALT/AST induced by heptatitis virus. In addition, the IL-22 dimer of this invention can effectively treat viral hepatitis.

公开(公告)号：EP2698365B1

公开(公告)日：2017-12-13

申请号：EP12771389.9

申请日：2012-04-02

Applicant: National University Corporation Tottori University ,  Tokyo Women's Medical University ,  Kanoncure, Inc.

Inventor： SHIOTA, Goshi ,  HOSHIKAWA, Yoshiko ,  MATSUMOTO, Noriko ,  MATSUMI, Yoshiaki ,  MORIMOTO, Minoru ,  TONOI, Takayuki ,  SAIMOTO, Hiroyuki ,  OHASHI, Kazuo ,  OKANO, Teruo

IPC: C07D487/04 ,  C07D307/52 ,  C07C251/86 ,  C07C43/225 ,  A61L27/00 ,  C12N5/071

CPC classification number: A61K35/407 ,  A61L27/3804 ,  A61L27/3834 ,  A61L2430/28 ,  C07C43/225 ,  C07C251/86 ,  C07D307/52 ,  C07D487/04

Abstract: The purpose is to select low-molecular-weight compounds which are effective in inducing differentiation of mesenchymal stem cell into hepatocyte and to develop a safe differentiation-inducing method having excellent efficiency of differentiating mesenchymal stem cell into hepatocyte. Provided are at least one compound selected from the group consisting of compounds represented by formulae (1) and (2), a salt thereof, or a solvate of them; a differentiation inducer comprising at least one compound selected from the group consisting of compounds represented by formulae (1) and (2), a salt thereof, or a solvate of them; and a differentiation inducer comprising a compound represented by formula (8), a salt thereof, or a solvate of them.

公开(公告)号：EP3240893A1

公开(公告)日：2017-11-08

申请号：EP15831197.7

申请日：2015-12-29

Applicant: The Brigham and Women's Hospital, Inc.

Inventor： SACKSTEIN, Robert

IPC: C12N5/0797 ,  C12N5/078 ,  C12N5/0783 ,  C12N5/0784 ,  C12N5/077 ,  A61K35/12

CPC classification number: A61K35/30 ,  A61K35/14 ,  A61K35/28 ,  A61K35/32 ,  A61K35/33 ,  A61K35/34 ,  A61K35/35 ,  A61K35/37 ,  A61K35/407 ,  A61K35/42 ,  A61K2035/124 ,  C12N5/0006 ,  C12N2501/724

Abstract: Methods of treatment are provided herein, including administration of a population cells modified to enforce expression of an E-selectin and/or an L-selectin ligand, the modified cell population having a cell viability of at least 70% after a treatment to enforce such expression.

公开(公告)号：EP3066193A4

公开(公告)日：2017-04-19

申请号：EP14857985

申请日：2014-11-03

Applicant: ISOPOGEN PTY LTD

Inventor： STURM MARLAN JUNE

IPC: C12N5/02 ,  A61K35/30 ,  A61K35/33 ,  A61K35/36 ,  A61K35/407 ,  C12N5/071 ,  C12N5/0775

CPC classification number: C12N5/0652 ,  A61K35/28 ,  A61K35/30 ,  A61K35/33 ,  A61K35/34 ,  A61K35/36 ,  A61K35/407 ,  C12N5/0663 ,  C12N2500/84

Abstract: The present invention is directed towards methods for producing cell and tissue compositions suitable for therapeutic applications to a mammal in need of a therapeutic cell or tissue treatment. In particular, the invention is directed towards a method of culturing cells for use in therapy, which method comprises (i) culturing a sample of cells in a first cell culture medium and (ii) prior to harvesting cells for use in therapy culturing the cells in a second cell culture medium.

Abstract translation: 本发明涉及用于生产适用于需要治疗性细胞或组织治疗的哺乳动物的治疗应用的细胞和组织组合物的方法。 特别地，本发明涉及培养用于治疗的细胞的方法，该方法包括（i）在第一细胞培养基中培养细胞样品，和（ii）在收获用于培养细胞的治疗的细胞之前 在第二细胞培养基中。

公开(公告)号：EP2083835B1

公开(公告)日：2017-03-15

申请号：EP07824439.9

申请日：2007-11-02

Applicant: Systagenix Wound Management IP Co. BV.

Inventor： CLARK, Rachael Louise ,  CULLEN, Breda Mary ,  MATHESON, Lindsay

IPC: A61K35/407 ,  A61K35/14 ,  A61P17/02

CPC classification number: A61L15/40 ,  A61K35/15 ,  A61K35/407 ,  A61L15/28 ,  A61L15/325 ,  A61L15/425 ,  A61L15/64

Abstract: A wound dressing composition comprising a non-viable cell lysate or releasate derived from a hepatocyte cell or an inflammatory cell such as a macrophage. Also provided are wound dressings comprising such compositions, methods of making such compositions, and the use of such compositions for the treatment of wounds.

公开(公告)号：EP3064575A1

公开(公告)日：2016-09-07

申请号：EP13896838.3

申请日：2013-11-05

Applicant: BBHC Co. Ltd.

Inventor： LEE, Sang Yeon ,  JUNG, Won Ju ,  KIM, Ho Bin ,  OH, Min Sun ,  LEE, Kye Ho

IPC: C12N5/02 ,  C12N5/0775

CPC classification number: C12N5/067 ,  A61K35/407 ,  C12N5/0665 ,  C12N2500/25 ,  C12N2500/76 ,  C12N2501/10 ,  C12N2501/12 ,  C12N2501/30 ,  C12N2501/33 ,  C12N2501/999 ,  C12N2502/137 ,  C12N2506/13 ,  C12N2506/1369 ,  C12N2506/45

Abstract: The present invention relates to a medium composition containing an Ecklonia cava extract for dedifferentiation an induced pluripotent stem cell. Also, the present invention relates to a method for differentiating an induced pluripotent stem cell produced by using the medium composition into hepatocytes. When using the medium composition according to the present invention, induced pluripotent stem cells using mesenchymal stem cells can be produced efficiently, and the pluripotent stem cells which have been produced can be useful as a cell treatment agent by being capable of being differentiated into hepatocytes.

Abstract translation: 本发明涉及一种介质组合物在用于诱导多能干细胞的去分化Ecklonia静脉提取包含。 所以，本发明涉及一种用于区分在通过使用介质组合物成肝细胞产生诱导性多能干细胞的方法。 当使用介质组合物雅丁在本发明中，使用间充质干细胞诱导多能干细胞可以有效地制造，并已生产出的多能干细胞可以通过能够被分化成肝细胞是作为细胞治疗剂是有用的。

公开(公告)号：EP2233150B1

公开(公告)日：2016-09-07

申请号：EP10005293.5

申请日：2004-12-30

Applicant: Bader, Augustinus

Inventor： Bader, Augustinus

IPC: A61K38/18 ,  A61K35/407 ,  A61K35/12 ,  A61P17/02 ,  A61P1/16

CPC classification number: A61K38/1816 ,  A61K35/407 ,  A61K38/196 ,  A61L27/3804 ,  A61L27/54 ,  A61L2300/414 ,  A61K2300/00