公开(公告)号：EP4370099A1

公开(公告)日：2024-05-22

申请号：EP22842957.7

申请日：2022-07-15

申请人： Celator Pharmaceuticals, Inc.

发明人： TARDI, Paul ,  WAN, Leon ,  GARG, Shyam Madhusudan ,  GAO, Jun ,  LEGROS, Philippe

IPC分类号： A61K9/127 ,  A61K9/10 ,  A61K9/00 ,  A61K31/00

CPC分类号： A61K9/1272 ,  A61K31/635 ,  A61K45/06 ,  A61P35/00

公开(公告)号：EP4370098A1

公开(公告)日：2024-05-22

申请号：EP22842954.4

申请日：2022-07-15

申请人： Celator Pharmaceuticals, Inc.

发明人： TARDI, Paul ,  WAN, Leon ,  GARG, Shyam Madhusudan ,  GAO, Jun ,  LEGROS, Philippe

IPC分类号： A61K9/127 ,  A61K9/10 ,  A61K31/015 ,  A61K31/00

CPC分类号： A61K9/1272 ,  A61K31/635 ,  A61K45/06 ,  A61P35/00

公开(公告)号：EP4309657A3

公开(公告)日：2024-02-28

申请号：EP23202449.7

申请日：2014-02-03

申请人： Celator Pharmaceuticals, Inc.

发明人： HAYES, Mark E. ,  NOBLE, Charles O. ,  SZOKA, Francis C., Jr.

IPC分类号： A61K9/127 ,  A61K9/19 ,  A61K31/4196 ,  A61K31/496 ,  A61K31/5377

摘要： The present invention provides liposome compositions containing sparingly soluble drugs that are used to treat life-threatening diseases. A preferred method of encapsulating a drug inside a liposome is by remote or active loading. Remote loading of a drug into liposomes containing a transmembrane electrochemical gradient is initiated by co-mixing a liposome suspension with a solution of drug, whereby the neutral form of the compound freely enters the liposome and becomes electrostatically charged thereby preventing the reverse transfer out of the liposome. There is a continuous build-up of compound within the liposome interior until the electrochemical gradient is dissipated or all the drug is encapsulated in the liposome. However, this process as described in the literature has been limited to drugs that are freely soluble in aqueous solution or solubilized as a water-soluble complex. This invention describes compositions and methods for remote loading drugs with low water solubility (

公开(公告)号：EP3856198A1

公开(公告)日：2021-08-04

申请号：EP19864378.5

申请日：2019-09-25

申请人： Celator Pharmaceuticals, Inc.

发明人： WANG, Qi ,  CHEUNG, Ronald ,  FADERL, Stefan

IPC分类号： A61K31/704 ,  A61K31/7068 ,  A61K9/127 ,  A61K39/395 ,  A61P35/02

公开(公告)号：EP3322404A1

公开(公告)日：2018-05-23

申请号：EP16825199.9

申请日：2016-07-14

申请人： Celator Pharmaceuticals, Inc.

发明人： WAN, Leon ,  LUI, Winnie ,  TARDI, Paul ,  MAYER, Lawrence

IPC分类号： A61K9/00

CPC分类号： A61K9/5153 ,  A61K9/0019 ,  A61K9/5192 ,  A61K31/337 ,  A61K31/4184 ,  A61K31/517 ,  A61K31/5377 ,  A61K47/554

摘要： Nanopaiticle compositions described herein comprise combinations of prodrugs of therapeutic agents that achieve enhanced therapeutic effects as compared to those observed when combinations of free forms of these therapeutic agents are administered.

公开(公告)号：EP2120568B1

公开(公告)日：2017-11-15

申请号：EP08730048.9

申请日：2008-02-15

申请人： Celator Pharmaceuticals, Inc.

发明人： LOUIE, Arthur ,  SWENSON, Christine ,  MAYER, Lawrence ,  JANOFF, Andrew

IPC分类号： A01N43/04 ,  A61K31/70 ,  A61K9/127 ,  A61K9/00

CPC分类号： A61K31/70 ,  A61K9/0019 ,  A61K9/127 ,  Y10T436/143333

公开(公告)号：EP2222278B1

公开(公告)日：2015-04-08

申请号：EP08855240.1

申请日：2008-11-26

申请人： Celator Pharmaceuticals, Inc.

发明人： ANSELL, Steven, M. ,  JOHNSTONE, Sharon ,  TARDI, Paul ,  MAYER, Lawrence

IPC分类号： A61K9/107 ,  A61K31/337 ,  A61K47/48 ,  C07D305/14

CPC分类号： A61K9/1075 ,  A61K9/5123 ,  A61K9/5146 ,  A61K31/337 ,  A61K47/543 ,  C07D305/14

公开(公告)号：EP2768484A1

公开(公告)日：2014-08-27

申请号：EP12841616.1

申请日：2012-10-15

申请人： Celator Pharmaceuticals, Inc.

发明人： CABRAL-LILLY, Donna ,  MAYER, Lawrence ,  TARDI, Paul ,  WATKINS, David ,  ZENG, Yi

IPC分类号： A61K9/127

CPC分类号： A61K9/127 ,  A61K9/1277 ,  A61K9/19 ,  A61K31/4745 ,  A61K31/704 ,  A61K31/7068 ,  A61K31/7072 ,  A61K45/06 ,  A61K47/26

摘要： Lyophilized liposomal formulations with two or more encapsulated drugs are disclosed. These formulations display superior drug retention profiles and also maintain size distribution following lyophilization and reconstitution.

公开(公告)号：EP1432403B1

公开(公告)日：2010-07-28

申请号：EP02766998.5

申请日：2002-10-03

申请人： Celator Pharmaceuticals, Inc.

发明人： TARDI, Paul ,  JOHNSTONE, Sharon ,  WEBB, Murray ,  BALLY, Marcel ,  ABRAHAM, Sheela

IPC分类号： A61K9/127

CPC分类号： A61K31/7072 ,  A61K9/127 ,  A61K9/1271 ,  A61K9/1272 ,  A61K31/00 ,  A61K31/4745 ,  A61K31/704 ,  A61K31/7048 ,  A61K31/7076 ,  A61K33/24 ,  A61K45/06 ,  A61K2300/00

公开(公告)号：EP2187869A1

公开(公告)日：2010-05-26

申请号：EP08871849.9

申请日：2008-08-14

申请人： Celator Pharmaceuticals, Inc.

发明人： TARDI, Paul ,  JOHNSTONE, Sharon ,  MAYER, Lawrence

IPC分类号： A61K9/127

CPC分类号： A61K9/127 ,  A61K9/0019 ,  A61K31/4745 ,  A61K31/555 ,  A61K33/24

摘要： Compositions which comprise liposomes having controlled release of a platinum agent are useful in achieving enhanced therapeutic effects particularly when these drugs are administered in combination with other therapeutic agents.