公开(公告)号：EP0605536A4

公开(公告)日：1994-07-20

申请号：EP92919974

申请日：1992-09-08

申请人： SCIOS NOVA INC

发明人： DOMB ABRAHAM J ,  MANIAR MANOJ

IPC分类号： A61K9/22 ,  A61K6/00 ,  A61K9/20 ,  A61K47/30 ,  A61K47/48 ,  A61L31/06 ,  A61L31/16 ,  C08G63/00 ,  C08G67/00 ,  C08G67/04 ,  C08G69/10 ,  C08G69/48

CPC分类号： A61L27/16 ,  A61K9/2031 ,  A61K47/59 ,  A61L27/18 ,  A61L31/06 ,  A61L31/16 ,  A61L2300/00 ,  C08G67/04 ,  C08L73/02

摘要： Fatty acid terminated polyanhydrides suitable for use as controlled release matrices in biodegradable sustained release drug delivery systems and methods for making thereof as described. The polymers are more soluble in organic solvents, and have a lower melting point than the corresponding non-fatty acid terminated polyanhydrides. The fatty acid terminated polyanhydrides are also more hydrophobic than the corresponding polyanhydrides that are not terminated with a fatty acid, and combine the properties of thermodynamic and hydrolytic stability, and easy storage. The polymers can be produced with a controlled and low molecular weight. The polyanhydrides are useful in a number of applications, including as a matrix in biodegradable drug delivery systems.

公开(公告)号：EP0647268A4

公开(公告)日：1993-05-27

申请号：EP91912653

申请日：1991-06-17

申请人： SCIOS NOVA INC

发明人： CORDELL BARBARA

IPC分类号： A01K67/027 ,  C07K14/47 ,  C12N15/09 ,  C12N15/85 ,  C12P21/02 ,  C12R1/91 ,  C12N15/00 ,  C12N15/12 ,  C12N15/18

CPC分类号： C12N15/85 ,  A01K67/0278 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/0312 ,  C07K14/4711 ,  C12N15/8509 ,  C12N2830/002 ,  C12N2830/008 ,  C12N2830/15 ,  C12N2830/42 ,  C12N2830/85

摘要： Cloned recombinant or synthetic DNA sequences related to the pathology of Alzheimer's disease are injected into fertilized mammalian eggs (preferably mice eggs). The injected eggs are implanted in pseudo pregnant females and are grown to term to provide transgenic mice whose cells express proteins related to the pathology of Alzheimer's disease. The injected sequences are constructed having promoter sequences connected so as to express the desired protein in specific tissues of the transgenic mammal (most notably in nerve tissue). The proteins which are preferably ubiquitously expressed include (1) β-amyloid core precursor proteins; and (2) β-amyloid related precursor proteins; and (3) serine protease inhibitor. The transgenic mice provide useful models for studying compounds being tested for their usefulness in treating Alzheimer's disease, and for studying the in vivo interrelationships of these proteins to each other.

公开(公告)号：EP0527763A1

公开(公告)日：1993-02-24

申请号：EP91907322.0

申请日：1991-03-28

申请人： SCIOS NOVA INC.

发明人： SCHEUERMANN, Trina, A. ,  TARNOWSKI, S., Joseph ,  THOMPSON, Stewart, A. ,  SILVERNESS, Kate, Baptie

IPC分类号： C12N15 ,  C07K1 ,  C07K14 ,  C12P21 ,  C12R1

CPC分类号： C07K14/503 ,  B01D15/3828

摘要： Procédé d'isolation et de purification de protéines telles que le facteur de croissance de fibroblaste utilisant la chromatographie en colonne par affinité de chélates métalliques, et sans l'emploi d'héparine.