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公开(公告)号:EP3845687A1
公开(公告)日:2021-07-07
申请号:EP19855515.3
申请日:2019-08-23
申请人: Tosoh Corporation
发明人: SUZUKI, Naoto , ESHITA, Akinori
摘要: To provide electrolytic manganese dioxide excellent in low rate characteristics and middle rate characteristics when used as a cathode material for alkaline manganese dry cells, and a method for its production.
Electrolytic manganese dioxide of which the apparent density is at least 4.0 g/cm 3 and at most 4.3 g/cm 3 , and the mode particle size is at least 30 µm and at most 100 µm; a method for its production and its application.-
公开(公告)号:EP3839048A1
公开(公告)日:2021-06-23
申请号:EP19850701.4
申请日:2019-08-08
发明人: HAYASHI, Masahiro , MARUYAMA, Takahiro , ITO, Hiroyuki , ASAGOSHI, Aya , HATAYAMA, Kouta , HOYA, Megumi
IPC分类号: C12N15/31 , B01D15/38 , B01J20/24 , B01J20/30 , C07K14/195 , C12N1/21 , C12N15/70 , C12P21/02 , C07K17/08
摘要: The present invention aims to provide a fucose-binding protein that shows improved productivity in cases of expression in a host such as Escherichia coli, improved binding affinity to a fucose-containing sugar chain such as a sugar chain containing a structure composed of Fucα1-2Galβ1-3GlcNAc and/or Fucα1-2Galβ1-3GalNAc, and/or improved thermal stability. The above object is achieved by deleting a plurality of amino acid residues in the C-terminal side of the amino acid sequence of the fucose-binding protein BC2LCN of SEQ ID NO: 1, and, when necessary, substituting the glycine residue at position 36 in SEQ ID NO: 1 with a cysteine residue, substituting the glutamine residue at position 39 in SEQ ID NO: 1 with a leucine residue or methionine residue, substituting the glutamine residue at position 65 in SEQ ID NO: 1 with a leucine residue, substituting the cysteine residue at position 72 in SEQ ID NO: 1 with a glycine residue or alanine residue, substituting the glutamic acid residue at position 81 in SEQ ID NO: 1 with a cysteine residue, glutamine residue, histidine residue, or methionine residue, and/or substituting the glycine residue identified as the residue at position 36 in SEQ ID NO: 1 with a cysteine residue.
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公开(公告)号:EP3812759A1
公开(公告)日:2021-04-28
申请号:EP19822237.4
申请日:2019-06-18
申请人: Tosoh Corporation
IPC分类号: G01N30/88 , B01J20/26 , B01J20/281 , B01J20/30 , B01J20/34 , G01N33/50 , G01N33/53 , C07K1/22 , C07K14/705 , C12N15/12 , C12N15/63 , C12Q1/686 , C12Q1/6876
摘要: An object of the present invention is to provide a method for detecting the presence or absence of a disease, the risk of developing a disease, the degree of progression of a disease and/or the degree of progression of aging, in a subject. The present invention achieves the above described object by a method including the following steps (a) to (c): (a) adding a solution containing an antibody obtained from a subject to a column filled with an insoluble carrier on which an Fc-binding protein is immobilized, to allow the antibody to be adsorbed on the carrier; (b) eluting the antibody adsorbed on the carrier using an eluent, to obtain data of a separation pattern of the antibody; and (c) detecting the presence or absence of a disease, the risk of developing a disease, the degree of progression of a disease and/or the degree of progression of aging, in the subject, using the data as an indicator.
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公开(公告)号:EP3742166A1
公开(公告)日:2020-11-25
申请号:EP18901702.3
申请日:2018-12-26
IPC分类号: G01N33/68 , G01N27/62 , G01N33/574
摘要: An object of the present invention is to provide a method for detecting renal cancer, and a reagent that can be used for the method. Provided is a method for detecting renal cancer, which includes measuring the amount of TFPI2 in a sample derived from a patient. An antibody that specifically recognizes NT-TFPI2 and intact TFPI2 is included in a detection reagent for renal cancer.
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公开(公告)号:EP3725743A1
公开(公告)日:2020-10-21
申请号:EP18889743.3
申请日:2018-12-12
申请人: Tosoh Corporation
发明人: CHEN Ning , NARAKI Yusuke
摘要: Provided is a β-zeolite that has an SiO 2 /Al 2 O 3 ratio of less than 20 but yet is comparable or superior in heat resistance to conventional β-zeolites having SiO 2 /Al 2 O 3 ratio of 20 or greater. This β-zeolite is characterized in that: in powder X-ray diffractometry using a CuKα-ray as a ray source, the full width at half maximum of a powder X-ray diffraction peak on the (302) plane is 0.15-0.50 inclusive; and the molar ratio of silica to alumina is less than 20.0. Preferably, the β-zeolite is obtained by a production method which comprises a crystallization step for crystallizing a composition comprising an alumina source, a silica source, an alkali source, a tetraethylammonium cation source and water, characterized in that the composition contains potassium and the molar ratio of potassium to silica exceeds 0.04.
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公开(公告)号:EP3708667A1
公开(公告)日:2020-09-16
申请号:EP18875049.1
申请日:2018-11-08
申请人: TOSOH CORPORATION
发明人: YAMANAKA, Naoki , UCHIDA, Yukie , TERAO, Yosuke
摘要: The invention aims to provide an immunoglobulin-binding protein having improved chemical stability, especially stability against alkali. The object can be achieved by improving stability against alkali by substituting an amino acid residue(s) at a particular position(s) in an immunoglobulin-binding domain such as domain C of protein A derived from a bacterium belonging to the genus Staphylococcus, to another/other particular amino acid residue(s).
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公开(公告)号:EP2650271B1
公开(公告)日:2020-09-09
申请号:EP11846891.7
申请日:2011-11-25
申请人: Tosoh Corporation
发明人: MESUDA Masami , KURAMOCHI Hideto , IIGUSA Hitoshi , OMI Kenji , SHIBUTAMI Tetsuo
IPC分类号: C04B35/453 , C23C14/08 , C23C14/34 , H01L21/363
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公开(公告)号:EP3702462A1
公开(公告)日:2020-09-02
申请号:EP18871565.0
申请日:2018-10-26
申请人: Tosoh Corporation
发明人: WATANABE, Ryoko , ENDO, Satoshi , TERAO, Yosuke , OE, Seigo
摘要: The present invention relates to an Fc-binding protein exhibiting improved alkaline resistance, a method for producing said protein, an antibody adsorbent obtained by immobilizing said protein on a carrier, and a method for separating an antibody using said adsorbent.
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公开(公告)号:EP3176197B1
公开(公告)日:2020-05-06
申请号:EP15826315.2
申请日:2015-07-28
申请人: Tosoh Corporation
IPC分类号: C08G18/76 , C08G18/10 , C08J9/28 , C08G101/00 , C08G18/48
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