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31.发明公开INTRAVENOUS ACCESS DEVICE HAVING INTEGRATED HEMODYNAMIC RESUSCITATION SYSTEM AND RELATED METHODS 审中-公开一个集成的血流动力学复兴系统及相关方法静脉接入设备
公开(公告)号：EP2892582A4
公开(公告)日：2016-11-09
申请号：EP13835216
申请日：2013-09-10
申请人： UNIV VANDERBILT
发明人： SEXTON KEVIN , EAGLE SUSAN , HOCKING KYLE , BAUDENBACHER FRANZ , BROPHY COLLEEN , BOYER RICHARD
CPC分类号： A61M5/1723 , A61B5/0002 , A61B5/0205 , A61B5/02152 , A61B17/1355 , A61M2005/14208 , A61M2205/3344 , A61M2205/3561 , A61M2205/3584 , A61M2205/3592 , A61M2205/50 , A61M2205/502 , A61M2230/30
摘要： One aspect of the present disclosure is a system for hemodynamic resuscitation. The system includes an intravenous access device having a pressure sensor element configured to detect a peripheral venous pressure value in response to an occlusion of a peripheral vein. The system also includes a controller device that is configured to receive a signal from the pressure sensor comprising the peripheral venous pressure value, to process the signal to determine a hemodynamic parameter based on the peripheral venous pressure value, and to generate a resuscitation score based on the hemodynamic parameter.
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32.发明公开METHODS AND COMPOSITIONS COMPRISING AKT INHIBITORS AND/OR PHOSPHOLIPASE D INHIBITORS 审中-公开方法和组合物与AKT抑制剂和/或磷脂酶D抑制剂
公开(公告)号：EP2931277A4
公开(公告)日：2016-07-27
申请号：EP13863529
申请日：2013-12-11
申请人： UNIV VANDERBILT
发明人： BROWN H ALEX , LINDSLEY CRAIG W
IPC分类号： A61K31/4468 , A61K31/435 , A61K31/436 , A61K31/438 , A61K31/454 , A61K31/713 , A61K45/00 , A61P35/00
CPC分类号： A61K31/713 , A61K31/435 , A61K31/436 , A61K31/438 , A61K31/454 , A61K45/06 , A61K2300/00
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33.发明公开METHODS AND SYSTEMS FOR CUSTOMIZING COCHLEAR IMPLANT STIMULATION AND APPLICATIONS OF SAME 有权个性化人工耳蜗植入的刺激与方法和系统及其用途
公开(公告)号：EP2833833A4
公开(公告)日：2015-12-30
申请号：EP13772589
申请日：2013-04-03
申请人： UNIV VANDERBILT
IPC分类号： A61F2/18 , A61B5/00 , A61B5/03 , A61B5/12 , A61B6/00 , A61B6/03 , A61B19/00 , A61F2/02 , A61F2/76 , A61N1/05 , A61N1/36 , G06F19/00 , G06T7/00 , H04R25/00
CPC分类号： A61N1/36032 , A61B5/12 , A61B5/4893 , A61B6/032 , A61B6/501 , A61B6/5235 , A61B34/10 , A61B2034/104 , A61B2034/105 , A61N1/0541 , A61N1/36036 , A61N1/36185 , G06T7/12 , G06T7/149 , G06T7/30 , G06T7/337 , G06T7/74 , G06T2207/10081 , G06T2207/20124 , G06T2207/20128 , G06T2207/30052 , G16H50/50 , H04R25/50 , H04R25/606
摘要： One aspect of the invention provides a method for customizing cochlear implant stimulation of a living subject. The cochlear implant includes an electrode array having a plurality of electrodes implanted in a cochlea of the living subject. The method includes determining a position for each of the plurality of electrodes and spiral ganglion nerves that the electrode array stimulates, determining a geometric relationship between neural pathways within the cochlea and the electrode array implanted therein, and using one or more electrodes of the electrode array to stimulate a group of SG neural pathways of the cochlea based on the location of the one or more electrodes and their geometric relationship with the neural pathways.
摘要翻译： 本发明的一个方面提供了一种用于定制活体的耳蜗植入物的刺激的方法。 耳蜗植入体包括在具有在所述活体的耳蜗植入电极的多根电极阵列。 该方法包括确定挖掘用于每个电极和螺旋神经节神经做了电极阵列刺激的，确定性的采矿耳蜗及所植入的电极阵列内的神经通路之间的几何关系的多个位置，以及使用该电极阵列的一个或多个电极 刺激一组基于所述一个或多个电极的位置及其与神经通路的几何关系耳蜗的SG神经通路。
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34.发明公开SUBSTITUTED BICYCLIC ALKOXY PYRAZOLE ANALOGS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS 审中-公开的mGluR5受体的取代的二环ALKOXYPYRAZOLANALOGA ALS变构调节剂
公开(公告)号：EP2863922A4
公开(公告)日：2015-11-04
申请号：EP13806565
申请日：2013-06-19
申请人： UNIV VANDERBILT
发明人： CONN JEFFREY P , LINDSLEY CRAIG W , STAUFFER SHAUN R , BARTOLOMÉ-NEBREDA JOSE MANUEL , MACDONALD GREGOR JAMES , CONDE-CEIDE SUSANA , TONG HAN MIN , PENA-PINON MIGUEL ANGEL , ALCÁZAR-VACA MANUEL JESUS , ANDRÉS-GIL JOSE IGNACIO
IPC分类号： C07D487/04 , A61K31/55 , A61P25/00
CPC分类号： C07D487/04
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35.发明公开SUBSTITUTED BICYCLIC ALKOXY PYRAZOLE ANALOGS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS 审中-公开的mGluR5受体的取代的二环ALKOXYPYRAZOLANALOGA ALS变构调节剂
公开(公告)号：EP2863912A4
公开(公告)日：2015-11-04
申请号：EP13807306
申请日：2013-06-19
申请人： UNIV VANDERBILT
发明人： CONN P JEFFREY , LINDSLEY CRAIG W , STAUFFER SHAUN R , BARTOLOME-NEBREDA JOSE MANUEL , MACDONALD GREGOR JAMES , CONDE-CEIDE SUSANA , TONG HAN MIN , ALCAZAR-VACA MANUEL JESUS , ANDRÉS-GIL JOSÉ IGNACIO , PENA-PIÑON MIGUEL ANGEL
IPC分类号： C07D487/04 , A61K31/4985 , A61K31/551 , A61P25/00
CPC分类号： A61K31/4985 , A61K31/506 , A61K31/551 , C07D487/04
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公开(公告)号：EP2760447A4
公开(公告)日：2015-10-21
申请号：EP12835711
申请日：2012-09-30
申请人： UNIV VANDERBILT
发明人： LINDSLEY CRAIG W , BROWN H ALEX
IPC分类号： A61K31/05 , A61K31/138 , A61K31/231 , A61K31/4535 , A61K31/454 , A61K31/661 , A61K45/06 , A61P31/16 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D471/10
CPC分类号： C07D471/10 , A61K31/05 , A61K31/138 , A61K31/231 , A61K31/435 , A61K31/4535 , A61K31/454 , A61K31/4709 , A61K31/498 , A61K31/661 , A61K45/06 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , A61K2300/00 , A61K31/683
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37.发明公开
公开(公告)号：EP2791569A4
公开(公告)日：2015-09-30
申请号：EP11877244
申请日：2011-12-16
申请人： UNIV VANDERBILT
发明人： BARTH ERIC J , TUCKER JOHN M
CPC分类号： F16L55/05 , B60T1/10 , B60Y2400/14 , F15B1/24 , F15B2201/20 , F15B2201/31 , Y02E60/15
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公开(公告)号：EP2756103A4
公开(公告)日：2015-06-03
申请号：EP12832172
申请日：2012-09-12
申请人： UNIV VANDERBILT
发明人： AUNE THOMAS M , CROOKE PHILIP S , OLSEN NANCY J , TOSSBERG JOHN T
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/158
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39.发明公开
公开(公告)号：EP2593029A4
公开(公告)日：2015-03-04
申请号：EP11807487
申请日：2011-07-13
发明人： MABARY JERRY E , VAEZI MICHAEL F , STUEBE THOMAS D
CPC分类号： A61B5/4233 , A61B5/037 , A61B5/0538 , A61B5/4211 , A61B5/6853 , A61B5/687 , A61B5/6885 , A61B5/7282 , A61B2562/0209 , A61B2562/046 , A61B2562/168
摘要： A mucosal impedance measuring system that is capable of direct and accurate impedance measurements of esophageal mucosa includes example multi-channel intraluminal impedance catheters with inflatable and deflatable components for positioning the impedance sensor electrodes in direct contact with the esophageal mucosa on the inside surface of the esophagus. Impedance measurements from multiple locations in the esophagus are processed for indications of mucosal damage that are indicative of damage due to gastrointestinal reflux disease (GERD), non-erosive reflux disease (NERD), and Barrett's esophagus.
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40.发明公开6-ALKYL-N-(PYRIDIN-2-YL)-4-ARYLOXYPICOLINAMIDE ANALOGS AS MGLUR5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME 审中-公开1-6 - 烷基-N-（吡啶-2-基）-4- aryloxypicolinamide类似物作为阴性的mGluR5变构调节剂及其制备方法和使用
公开(公告)号：EP2680849A4
公开(公告)日：2015-02-18
申请号：EP12752374
申请日：2012-03-05
申请人： UNIV VANDERBILT
发明人： CONN P JEFFREY , LINDSLEY CRAIG W , EMMITTE KYLE A , RODRIGUEZ ALICE L , FELTS ANDREW S , JONES CARRIE K , BATES BRITTNEY S , CHAUDER BRIAN A
IPC分类号： A61K31/513 , C07D401/14
CPC分类号： C07D401/14 , A61K31/513 , C07D213/81 , C07D401/12
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