公开(公告)号：EP2834245B1

公开(公告)日：2017-12-13

申请号：EP13712784.1

申请日：2013-03-27

申请人： Bayer Pharma Aktiengesellschaft

发明人： EIS, Knut ,  PÜHLER, Florian ,  ZORN, Ludwig ,  SCHULZE, Volker ,  SÜLZLE, Detlev ,  LIENAU, Philip ,  HÄGEBARTH, Andrea ,  PETERSEN, Kirstin ,  BÖMER, Ulf

IPC分类号： C07D487/04 ,  A61K31/5025 ,  A61P35/00

CPC分类号： C07D405/04 ,  A61K31/5025 ,  A61K31/5377 ,  A61K45/06 ,  C07D487/04

公开(公告)号：EP3224254A1

公开(公告)日：2017-10-04

申请号：EP15800828.4

申请日：2015-11-25

申请人： Bayer Pharma Aktiengesellschaft

发明人： BOTHE, Ulrich ,  SIEBENEICHER, Holger ,  SCHMIDT, Nicole ,  NUBBEMEYER, Reinhard ,  BÖMER, Ulf ,  GÜNTHER, Judith ,  STEUBER, Holger ,  LANGE, Martin ,  STEGMANN, Christian ,  SUTTER, Andreas ,  RAUSCH, Alexandra ,  HAUFF, Peter ,  FRIEDRICH, Christian

IPC分类号： C07D401/12 ,  A61K31/4439 ,  A61P9/00 ,  A61P17/00 ,  A61P29/00 ,  A61P35/00

摘要： The invention relates to new substituted indazoles, to methods for the production thereof, to the use thereof alone or in combinations to treat and/or prevent diseases, and to use thereof to produce drugs for treating and/or preventing diseases, in particular for treating and/or preventing endometriosis and endometriosis-associated pain and other symptoms associated with endometriosis such as dysmenorrhea, dyspareunia, dysuria, and dyschezia, lymphomas, rheumatoid arthritis, spondyloarthritides (in particular psoriatic spondyloarthritis and Bekhterev's disease), lupus erythematosus, multiple sclerosis, macular degeneration, COPD, gout, fatty liver diseases, insulin resistance, tumor diseases, and psoriasis.

摘要翻译： 本发明涉及新的取代的吲唑，其制备方法，其单独或组合使用以治疗和/或预防疾病，以及其用于制备用于治疗和/或预防疾病的药物，特别是用于治疗 和/或预防与子宫内膜异位症相关的子宫内膜异位症和子宫内膜异位相关疼痛和其他症状，例如痛经，性交痛，排尿困难和排便困难，淋巴瘤，类风湿性关节炎，脊柱关节炎（特别是银屑病性脊柱关节炎和贝赫特列夫氏病），红斑狼疮，多发性硬化症， 变性，COPD，痛风，脂肪肝疾病，胰岛素抵抗，肿瘤疾病和牛皮癣。

公开(公告)号：EP2920176B1

公开(公告)日：2017-09-13

申请号：EP13795702.3

申请日：2013-11-14

申请人： Bayer Pharma Aktiengesellschaft

发明人： ZORN, Ludwig ,  EIS, Knut ,  SCHULZE, Volker ,  SÜLZLE, Detlev ,  PÜHLER, Florian ,  LIENAU, Philip ,  BÖMER, Ulf ,  PETERSEN, Kirstin ,  HÄGEBARTH, Andrea

IPC分类号： C07D487/04 ,  A61K31/4355 ,  A61P35/00

CPC分类号： C07D487/04 ,  A61K31/5025 ,  A61K45/06 ,  C07D519/00

公开(公告)号：EP3004092B1

公开(公告)日：2017-03-22

申请号：EP14727534.1

申请日：2014-06-03

申请人： Bayer Pharma Aktiengesellschaft

发明人： SCHIROK, Hartmut ,  SCHULZE, Volker ,  KOSEMUND, Dirk ,  BRIEM, Hans ,  BADER, Benjamin ,  BÖMER, Ulf ,  WENGNER, Antje, Margret ,  SIEMEISTER, Gerhard ,  LIENAU, Philip

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P35/00

CPC分类号： C07D471/04 ,  A61K31/496 ,  A61K31/5377 ,  A61K45/06

公开(公告)号：EP2852596B1

公开(公告)日：2016-06-22

申请号：EP13725935.4

申请日：2013-05-17

申请人： Bayer Pharma Aktiengesellschaft

发明人： KETTSCHAU, Georg ,  PÜHLER, Florian ,  EIS, Knut ,  KLAR, Ulrich ,  KOSEMUND, Dirk ,  SÜLZLE, Detlev ,  LIENAU, Philip ,  HÄGEBARTH, Andrea ,  BÖMER, Ulf ,  WORTMANN, Lars ,  GRAHAM, Keith ,  WENGNER, Antje Margret

IPC分类号： C07D495/04 ,  C07D519/00 ,  A61K31/519 ,  A61P35/00

CPC分类号： C07D495/04 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/5513 ,  A61K45/06 ,  C07D519/00

公开(公告)号：EP3004092A1

公开(公告)日：2016-04-13

申请号：EP14727534.1

申请日：2014-06-03

申请人： Bayer Pharma Aktiengesellschaft

发明人： SCHIROK, Hartmut ,  SCHULZE, Volker ,  KOSEMUND, Dirk ,  BRIEM, Hans ,  BADER, Benjamin ,  BÖMER, Ulf ,  WENGNER, Antje, Margret ,  SIEMEISTER, Gerhard ,  LIENAU, Philip

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P35/00

CPC分类号： C07D471/04 ,  A61K31/496 ,  A61K31/5377 ,  A61K45/06

摘要： The present invention relates to substituted triazolopyridine compounds of general formula (I); in which R
1 , R
2 , R
3 , R
4 , and R
5 are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.

公开(公告)号：EP2928878A1

公开(公告)日：2015-10-14

申请号：EP13792885.9

申请日：2013-11-12

申请人： Bayer Pharma Aktiengesellschaft

发明人： LÜCKING, Ulrich ,  BÖHNKE, Niels ,  SCHOLZ, Arne ,  LIENAU, Philip ,  SIEMEISTER, Gerhard ,  BÖMER, Ulf ,  KOSEMUND, Dirk ,  BOHLMANN, Rolf ,  ZORN, Ludwig

IPC分类号： C07D401/12 ,  A61K31/44 ,  A61P35/00

CPC分类号： A61K31/444 ,  C07D213/72 ,  C07D401/12

摘要： The present invention relates to 5-fluoro-N-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfoximine group of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).

公开(公告)号：EP2909183A1

公开(公告)日：2015-08-26

申请号：EP13777039.2

申请日：2013-10-15

申请人： Bayer Pharma Aktiengesellschaft

发明人： LÜCKING, Ulrich ,  BOHLMANN, Rolf ,  KOSEMUND, Dirk ,  SCHOLZ, Arne ,  LIENAU, Philip ,  SIEMEISTER, Gerhard ,  BÖMER, Ulf

IPC分类号： C07D239/42 ,  A61K31/505 ,  A61P35/00

CPC分类号： C07D239/42 ,  A61K31/505 ,  C07D239/26

摘要： The present invention relates to 4-(ortho)-fluorophenyl-5-fluoropyrimidin-2-yl amine derivatives of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).

公开(公告)号：EP2909176A2

公开(公告)日：2015-08-26

申请号：EP13782670.7

申请日：2013-10-15

申请人： Bayer Pharma Aktiengesellschaft

发明人： LÜCKING, Ulrich ,  BÖHNKE, Niels ,  SCHOLZ, Arne ,  LIENAU, Philip ,  SIEMEISTER, Gerhard ,  BÖMER, Ulf ,  KOSEMUND, Dirk ,  BOHLMANN, Rolf ,  ZORN, Ludwig

IPC分类号： C07D213/74 ,  C07D405/14 ,  A61K31/506 ,  A61P9/00 ,  A61P31/12 ,  A61P35/00

CPC分类号： C07D213/74 ,  A61K31/444 ,  C07D405/14

摘要： The present invention relates to 5-fluoro-N-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfone group of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).

摘要翻译： 本发明涉及含有本文所述和定义的通式（I）的砜基的5-氟-N-（吡啶-2-基）吡啶-2-胺衍生物及其制备方法，其用于 治疗和/或预防疾病，特别是高增殖性疾病和/或病毒诱导的传染病和/或心血管疾病。 本发明还涉及可用于制备所述通式（I）化合物的中间体化合物。

公开(公告)号：EP2852595A1

公开(公告)日：2015-04-01

申请号：EP13723163.5

申请日：2013-05-17

申请人： Bayer Pharma Aktiengesellschaft

发明人： KLAR, Ulrich ,  KETTSCHAU, Georg ,  KOSEMUND, Dirk ,  PÜHLER, Florian ,  EIS, Knut ,  LIENAU, Philip ,  BÖMER, Ulf ,  SÜLZLE, Detlev ,  WORTMANN, Lars

IPC分类号： C07D495/04 ,  A61K31/38 ,  A61P35/00

CPC分类号： C07D495/04 ,  A61K31/38 ,  A61K31/519 ,  A61K45/06 ,  C07D519/00

摘要： The present invention relates to substituted benzothienopyrimidine compounds of general formula I: in which R
1a , R
1b , R
2a , R
2b , and R
2c are as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.

摘要翻译： 本发明涉及通式I的取代的苯并噻吩并嘧啶化合物：其中R 1a，R 1b，R 2a，R 2b和R 2c如本文所述和定义，涉及制备所述化合物的方法，涉及用于制备 所述化合物，含有所述化合物的药物组合物和组合以及所述化合物在制备用于治疗或预防疾病，特别是过度增殖和/或血管生成障碍的药物组合物中的用途，或作为 与其他活性成分组合。