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公开(公告)号：EP2499132B1
公开(公告)日：2017-02-15
申请号：EP10779401.8
申请日：2010-11-10
发明人： LAVOIE, Rico , BENDER, John A. , ROMINE, Jeffrey Lee , RUEDIGER, Edward H. , BACHAND, Carol , LOPEZ, Omar D. , CHEN, Qi , BELEMA, Makonen , KADOW, John F. , HAMANN, Lawrence G.
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D403/14 , C07D409/14 , C07D417/14 , C07D493/08
CPC分类号： C07D417/14 , C07D401/14 , C07D403/06 , C07D403/10 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/10 , C07D419/10 , C07D493/08
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公开(公告)号：EP2331502B1
公开(公告)日：2016-03-02
申请号：EP09792143.1
申请日：2009-09-02
发明人： PRACITTO, Richard , KADOW, John F. , BENDER, John A. , BENO, Brett R. , GRANT-YOUNG, Katharine A. , HAN, Ying , HEWAWASAM, Piyasena , NICKEL, Andrew , PARCELLA, Kyle E. , YEUNG, Kap-Sun , CHUPAK, Louis S.
IPC分类号： C07D209/42 , C07D333/68 , C07D471/04 , C07D491/048 , A61K31/4745 , A61K31/4741 , A61K31/381
CPC分类号： C07D471/04 , C07D209/42 , C07D333/68 , C07D491/048
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公开(公告)号：EP2912031A1
公开(公告)日：2015-09-02
申请号：EP12781012.5
申请日：2012-10-24
发明人： ROMINE, Jeffrey Lee , YANG, Zhong , WANG, Gan , NGUYEN, Van N. , BENDER, John A. , ST.LAURENT, Denis R. , BELEMA, Makonen
IPC分类号： C07D405/14 , A61K31/4178 , A61P31/14
CPC分类号： A61K31/4178 , A61K45/06 , C07D403/14 , C07D405/14
摘要： The present disclosure relates to compounds, compositions and methods for the treatment of Hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
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公开(公告)号：EP2419433B1
公开(公告)日：2015-03-11
申请号：EP10714135.0
申请日：2010-04-08
IPC分类号： C07D513/04 , A61K31/428 , A61P31/14
CPC分类号： C07D513/04
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公开(公告)号：EP2603504A1
公开(公告)日：2013-06-19
申请号：EP11750005.8
申请日：2011-08-10
申请人： Bristol-Myers Squibb Company , Srinivasu, Pothukanuri , Gupta, Samayamunthula Venkata Satya Arun Kumar
发明人： SRINIVASU, Pothukanuri , GUPTA, Samayamunthula Venkata Satya Arun Kumar , BELEMA, Makonen , BENDER, John A. , LOPEZ, Omar D. , CHEN, Qi , RAMPULLA, Richard A. , MEANWELL, Nicholas A.
IPC分类号： C07D403/14 , C07D405/14 , C07D413/14 , C07D487/04 , A61K31/4178 , A61K31/433 , A61P31/12
CPC分类号： C07D403/14 , C07D405/14 , C07D413/14 , C07D487/04
摘要： The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
摘要翻译： 本公开涉及用于治疗丙型肝炎病毒（HCV）感染的化合物，组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。
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公开(公告)号：EP2499132A1
公开(公告)日：2012-09-19
申请号：EP10779401.8
申请日：2010-11-10
发明人： LAVOIE, Rico , BENDER, John A. , ROMINE, Jeffrey Lee , RUEDIGER, Edward H. , BACHAND, Carol , LOPEZ, Omar D. , CHEN, Qi , BELEMA, Makonen , KADOW, John F. , HAMANN, Lawrence G.
IPC分类号： C07D403/06 , C07D403/10 , C07D417/10 , C07D419/10 , C07D417/02 , C07D419/02 , A61K31/4178
CPC分类号： C07D417/14 , C07D401/14 , C07D403/06 , C07D403/10 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/10 , C07D419/10 , C07D493/08
摘要： This disclosure concerns novel compounds of Formula (I) or as defined in the specification and compositions comprising such novel compounds. These compounds are useful antiviral agents, especially in inhibiting the function of the NS5A protein encoded by Hepatitis C virus (HCV). Thus, the disclosure also concerns a method of treating HCV related diseases or conditions by use of these novel compounds or a composition comprising such novel compounds.
摘要翻译： 本公开涉及式（I）的新化合物或如说明书中定义的新化合物和包含此类新化合物的组合物。 这些化合物是有用的抗病毒剂，特别是在抑制由丙型肝炎病毒（HCV）编码的NS5A蛋白的功能中。 因此，本公开还涉及通过使用这些新化合物或包含这种新化合物的组合物来治疗HCV相关疾病或病症的方法。
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公开(公告)号：EP2209784B1
公开(公告)日：2012-08-01
申请号：EP08852063.0
申请日：2008-11-19
发明人： HEWAWASAM, Piyasena , TU, Yong , BENDER, John A. , YANG, Zhong
IPC分类号： C07D471/08 , C07D487/04
CPC分类号： C07D487/04 , C07D519/00
摘要： The invention encompasses compounds of formula (I) as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
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公开(公告)号：EP2398794A1
公开(公告)日：2011-12-28
申请号：EP10704290.5
申请日：2010-02-09
发明人： ROMINE, Jeffrey Lee , ST. LAURENT, Denis R. , BELEMA, Makonen , SNYDER, Lawrence B. , HAMANN, Lawrence G. , KADOW, John F. , KAPUR, Jayne , GOOD, Andrew C. , LOPEZ, Omar D. , LAVOIE, Rico , BENDER, John A.
IPC分类号： C07D403/14 , A61K31/4184 , A61K31/4178 , A61P31/12 , C07D413/14
CPC分类号： C07D403/14 , A61K31/4184 , A61K31/422 , A61K31/454 , A61K31/4725 , A61K31/7056 , A61K38/2013 , A61K38/204 , A61K38/208 , A61K38/21 , A61K38/212 , A61K45/06 , C07D405/14 , C07D413/14
摘要： The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
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39.发明授权CYCLOPROPYL FUSED INDOLOBENZAZEPINE HCV NS5B INHIBITORS 有权CYCLOPROPYLKONDENSIERTE INDOLOBENZAZEPINE AS HCV NS5B抑制剂
公开(公告)号：EP2209789B1
公开(公告)日：2011-11-16
申请号：EP07874300.2
申请日：2007-11-20
IPC分类号： C07D487/08 , A61K31/55 , A61P31/12
CPC分类号： C07D487/08
摘要： The invention encompasses compounds of formula (I) as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
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公开(公告)号：EP2331502A2
公开(公告)日：2011-06-15
申请号：EP09792143.1
申请日：2009-09-02
发明人： PRACITTO, Richard , KADOW, John F. , BENDER, John A. , BENO, Brett R. , GRANT-YOUNG, Katharine A. , HAN, Ying , HEWAWASAM, Piyasena , NICKEL, Andrew , PARCELLA, Kyle E. , YEUNG, Kap-Sun , CHUPAK, Louis S.
IPC分类号： C07D209/42 , C07D333/68 , C07D471/04 , C07D491/048 , A61K31/4745 , A61K31/4741 , A61K31/381
CPC分类号： C07D471/04 , C07D209/42 , C07D333/68 , C07D491/048
摘要： The disclosure provides compounds of formula I, II, III, IV, and V, including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.
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