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33 条记录 (耗时 0.012 秒)

    USE OF 4-IMIDAZOLE DERIVATIVES FOR CNS DISORDERS
    31.
    发明公开
    USE OF 4-IMIDAZOLE DERIVATIVES FOR CNS DISORDERS 有权
    4-咪唑衍生物用于CNS疾病中的用途

    公开(公告)号：EP1981880A2

    公开(公告)日：2008-10-22

    申请号：EP07703939.4

    申请日：2007-01-17

    申请人： F.HOFFMANN-LA ROCHE AG

    发明人： GALLEY, Guido ,  GROEBKE ZBINDEN, Katrin ,  HOENER, Marius ,  NORCROSS, Roger ,  STALDER, Henri

    IPC分类号： C07D405/06 ,  C07D233/54 ,  A61K31/4174 ,  A61K31/4178 ,  A61P25/00

    CPC分类号： C07D233/64 ,  C07D405/06

    摘要： The present invention relates to the use of compounds of formula (I) wherein R is hydrogen, halogen, lower alkyl, lower alkoxy, hydroxy, phenyl, S-phenyl or O-phenyl, which are optionally substituted by lower alkoxy or halogen, or is benzyloxy, C(O)O-lower alkyl, cycloalkyl, or is lower alkyl or lower alkoxy substituted by halogen; Ar is aryl or heteroaryl, selected from the group consisting of phenyl, naphthyl, pyridinyl, benzofuranyl, dihydrobenzofuranyl or pyrazole; R1/R1' are independently from each other hydrogen, hydroxy, lower alkyl, lower alkoxy or are phenyl or benzyl, which are optionally substituted by halogen; R2 is hydrogen or lower alkyl; n is 1, 2, 3 or 4; and to their pharmaceutically active salts, racemic mixtures, enantiomers, optical isomers and tautomeric forms for the preparation of medicaments for the treatment of depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder, stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinson's disease, neurodegenerative disorders such as Alzheimer's disease, epilepsy, migraine, hypertension, substance abuse and metabolic disorders such as eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.

    USE OF 2-IMIDAZOLES FOR THE TREATMENT OF CNS DISORDERS
    32.
    发明公开
    USE OF 2-IMIDAZOLES FOR THE TREATMENT OF CNS DISORDERS 审中-公开
    2-咪唑用于治疗中枢神经系统病症的用途

    公开(公告)号：EP1981499A1

    公开(公告)日：2008-10-22

    申请号：EP07703942.8

    申请日：2007-01-17

    申请人： F.HOFFMANN-LA ROCHE AG

    发明人： GALLEY, Guido ,  GROEBKE ZBINDEN, Katrin ,  NORCROSS, Roger ,  STALDER, Henri

    IPC分类号： A61K31/4166 ,  A61K31/4174 ,  A61K31/4709 ,  C07D233/06 ,  C07D233/54 ,  C07D401/04 ,  C07D405/04 ,  A61P25/18

    CPC分类号： C07D233/56 ,  A61K31/4166 ,  A61K31/4174 ,  A61K31/4709 ,  C07D233/06 ,  C07D233/20 ,  C07D233/22 ,  C07D233/64 ,  C07D401/04 ,  C07D401/06 ,  C07D405/04

    摘要： The present invention relates to the use of compounds of formula (I) R1 is hydrogen, tritium, hydroxy, lower alkyl, lower alkoxy, halogen, nitro, amino or lower alkyl substituted by halogen; R2 is hydrogen, hydroxy or lower alkyl; X is N and Y is CH or CH2 or CH-lower alkyl or X is CH and Y is N; Q is CH2, O, NH, N-alkyl or N-SO2-alkyl or N-SO2-toluen-4-yl; W is CH2 or a bond are independently from one another 1, 2 or 3; when m is 2 or 3, R2 may m, n be the same or not; when n is 2 or 3, R1 may be the same or not; the dotted lines may each be independently from one another a bond or not; and to their pharmaceutically active salts, racemic mixtures, enantiomers, optical isomers and tautomeric forms of compounds of formula (I) for the preparation of medicaments for the treatment of depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder, stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinson's disease, neurodegenerative disorders such as Alzheimer's disease, epilepsy, migraine, hypertension, substance abuse and metabolic disorders such as eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.

    摘要翻译： 本发明涉及式（I）化合物的用途，R 1是氢，氚，羟基，低级烷基，低级烷氧基，卤素，硝基，氨基或被卤素取代的低级烷基; R2是氢，羟基或低级烷基; X是N且Y是CH或CH 2或CH-低级烷基或X是CH且Y是N; Q为CH 2，O，NH，N-烷基或N-SO 2 - 烷基或N-SO 2 - 甲苯-4-基; W是CH 2或键彼此独立地是1,2或3; 当m是2或3时，R2可以是m，n可以相同或不同; 当n是2或3时，R1可​​以相同或不同; 虚线可以各自彼此独立地键合或不键合; （I）化合物的药物活性盐，外消旋混合物，对映异构体，旋光异构体和互变异构形式，用于制备用于治疗抑郁症，焦虑症，双相性精神障碍，注意力缺陷多动障碍，应激相关障碍 ，精神障碍如精神分裂症，神经疾病如帕金森病，神经变性疾病如阿尔茨海默病，癫痫，偏头痛，高血压，物质滥用和代谢障碍如进食障碍，糖尿病，糖尿病并发症，肥胖症，血脂异常，能量紊乱 和身体体温平衡的紊乱和失调，睡眠和昼夜节律失调以及心血管疾病。