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公开(公告)号：EP2630123A1
公开(公告)日：2013-08-28
申请号：EP11778520.4
申请日：2011-10-19
申请人： Grünenthal GmbH
IPC分类号： C07D213/82 , C07D401/04 , C07D401/14 , C07D405/12 , C07D413/04 , A61K31/4427 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/553 , A61P25/00 , C07D413/14
CPC分类号： C07D401/04 , C07D213/82 , C07D401/14 , C07D405/12 , C07D413/04 , C07D413/14
摘要： The invention relates to substituted 6 -amino-nicotinamides of general formula (I) to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
摘要翻译： 取代的6-氨基烟酰胺，含有这些化合物的药物组合物，以及这些化合物在治疗和/或预防疼痛和其它疾病和/或病症中的用途。
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32.发明公开SUBSTITUTED 1-OXO-DIHYDROISOQUINOLINE-3-CARBOXAMIDES AS KCNQ2/3 MODULATORS 审中-公开替代1-氧代二氢吲哚-3-羧酸盐KCNQ2 / 3调节剂
公开(公告)号：EP2611780A1
公开(公告)日：2013-07-10
申请号：EP11757547.2
申请日：2011-08-31
申请人： Grünenthal GmbH
IPC分类号： C07D217/26 , A61K31/472 , A61P25/00
CPC分类号： C07D217/26 , A61K31/472
摘要： The invention relates to substituted 1-oxo-dihydroisoquinoline-3-carboxamides, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
摘要翻译： 本发明涉及取代的1-氧代 - 二氢异喹啉-3-甲酰胺，含有这些化合物的药物组合物以及这些化合物用于治疗和/或预防疼痛和其它疾病和/或病症。
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33.发明公开SUBSTITUTED 2-OXO- AND 2-THIOXO-DIHYDROQUINOLINE-3-CARBOXAMIDES AS KCNQ2/3 MODULATORS 有权取代的2-氧代和-2-硫代二氢喹啉-3-羧酰胺AS KCNQ调节剂的2/3
公开(公告)号：EP2609086A1
公开(公告)日：2013-07-03
申请号：EP11754836.2
申请日：2011-08-26
申请人： Grünenthal GmbH
IPC分类号： C07D215/54 , A61K31/4704 , A61P25/00
CPC分类号： C07D215/54 , C07D405/04
摘要： The invention relates to substituted 2-oxo- and 2-thioxo-dihydroquinoline-3-carboxamides to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
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34.发明公开SUBSTITUTED QUINOLINE-3-CARBOXAMIDES AS KCNQ2/3 MODULATORS 审中-公开SUBSTITUIERTE CHINOLIN-3-CARBOXAMIDE ALS KCNQ-2/3-MODULATOREN
公开(公告)号：EP2609085A1
公开(公告)日：2013-07-03
申请号：EP11754835.4
申请日：2011-08-26
申请人： Grünenthal GmbH
IPC分类号： C07D215/54 , C07D409/12 , A61K31/47 , A61K31/4709 , A61P25/00
CPC分类号： C07D215/54 , C07D409/12
摘要： The invention relates to substituted quinoline-3-carboxamides of formula (I) as KCNQ2/3 modulators for use in the treatment and/or prophylaxis of pain and relates diseases and/or disorders.
摘要翻译： 本发明涉及取代的喹啉-3-羧酰胺，含有这些化合物的药物组合物以及这些化合物用于治疗和/或预防疼痛和其它疾病和/或病症。
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35.发明授权VERWENDUNG VON 2,5-DISUBSTITUIERTEN THIAZOL-4-ON-DERIVATEN IN ARZNEIMITTELN 有权维也纳冯二代V TEN TEN TEN TEN TEN N N N N N N N N N N N N
公开(公告)号：EP1890695B1
公开(公告)日：2013-02-20
申请号：EP06753682.1
申请日：2006-05-17
申请人： Grünenthal GmbH
发明人： FRANK, Robert , KLESS, Achim , JOSTOCK, Ruth
IPC分类号： A61K31/426 , A61K31/427 , A61K31/454 , A61K31/5377 , A61K31/541 , A61K31/55 , C07D277/34 , C07D417/06 , C07D277/42 , C07D277/54 , C07D417/12
CPC分类号： C07D277/34 , C07D277/42 , C07D277/54 , C07D417/12
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36.发明公开
公开(公告)号：EP2406224A1
公开(公告)日：2012-01-18
申请号：EP10708140.8
申请日：2010-03-11
申请人： Grünenthal GmbH
IPC分类号： C07D213/75 , C07D409/12 , A61K31/44 , A61K31/4427 , A61P25/08
CPC分类号： C07D213/75 , C07D409/12
摘要： The invention relates to substituted 2-mercapto-3-aminopyridines, methods for the production thereof, medicaments containing said compounds, and the use of said compounds for producing medicaments.
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37.发明授权GESÄTTIGTE UND UNGESÄTTIGTE HETEROARYLCYCLOALKYMETHYL-AMINE ALS ANTIDEPRESSIVA 有权饱和和非饱和HETEROARYLCYCLOALKYMETHYL胺抗抑郁药
公开(公告)号：EP1572653B1
公开(公告)日：2007-11-21
申请号：EP03815065.2
申请日：2003-12-19
申请人： Grünenthal GmbH
发明人： BLOMS-FUNKE, Petra , PÜTZ, Claudia , GRAUDUMS, Ivars , KLESS, Achim , GRIEBEL, Carsten , HENNIES, Hagen-Heinrich , KAULARTZ, Dagmar , REINARDY, Sabine , SAUNDERS, Derek , SCHIENE, Klaus , ENGLBERGER, Werner , ZIMMER, Oswald ,
IPC分类号： C07D213/38 , C07D213/61 , C07D213/65 , C07D405/04 , A61K31/4433 , A61K31/44 , A61P25/24 , A61P29/00
CPC分类号： C07D405/04 , C07D213/38 , C07D213/61 , C07D213/65
摘要： The invention relates to saturated and unsaturated heteroarylcycloalkylmethyl amines of general formula (I) wherein W is equal to CH2, O, S, SO or SO2, and n is equal to a number between 0 and 3. The invention also relates to a method for the production of said compounds, to medicaments containing the same, to the use of said compounds for producing medicaments, and to methods for treating depression, anxiety disorders and/or pain.
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公开(公告)号：EP3402781B1
公开(公告)日：2020-03-04
申请号：EP17700389.4
申请日：2017-01-13
申请人： Grünenthal GmbH
发明人： KÜHNERT, Sven , KOENIGS, René Michael , KLESS, Achim , WEGERT, Anita , KONETZKI, Ingo , RATCLIFFE, Paul , JOSTOCK, Ruth , KOCH, Thomas , LINZ, Klaus , SCHRÖDER, Wolfgang
IPC分类号： C07D235/02 , A61K31/4166 , A61P25/00
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公开(公告)号：EP3402785B1
公开(公告)日：2020-02-26
申请号：EP17702003.9
申请日：2017-01-13
申请人： Grünenthal GmbH
发明人： KÜHNERT, Sven , KOENIGS, René Michael , JAKOB, Florian , KLESS, Achim , RATCLIFFE, Paul , JOSTOCK, Ruth , KOCH, Thomas , LINZ, Klaus , SCHRÖDER, Wolfgang , SCHIENE, Klaus , WEGERT, Anita
IPC分类号： C07D235/02 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/12 , C07D487/04 , C07K5/062 , A61K31/4184 , A61P25/04
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公开(公告)号：EP3402783A1
公开(公告)日：2018-11-21
申请号：EP17700474.4
申请日：2017-01-13
申请人： Grünenthal GmbH
发明人： KÜHNERT, Sven , KOENIGS, René Michael , JAKOB, Florian , KLESS, Achim , WEGERT, Anita , RATCLIFFE, Paul , JOSTOCK, Ruth , KOCH, Thomas , LINZ, Klaus , SCHRÖDER, Wolfgang
IPC分类号： C07D235/02 , A61K31/4166 , A61P25/00
摘要： The invention relates to 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.
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