公开(公告)号：EP1383796B2

公开(公告)日：2012-08-22

申请号：EP02759815.0

申请日：2002-04-04

申请人： INSTITUT PASTEUR ,  Kimron Veterinary Institute

发明人： DESPRES, Philippe ,  DEUBEL, Vincent ,  GUENET, Jean-Louis ,  DROUET, Marie-Thérèse, Institut Pasteur ,  MALKINSON, Mertyn, Kimron Veterinary Institute ,  BANET, Caroline, Kimron Veterinary Institute ,  FRENKIEL, Marie-Pascale ,  COURAGEOT, Marie-Pierre ,  COULIBALY, Fasséli ,  CATTEAU, Adeline ,  FLAMAND, Marie ,  WEBER, Patrick ,  CECCALDI, Pierre-Emmanuel

IPC分类号： C12N7/00

CPC分类号： C07K14/005 ,  A61K39/00 ,  C12N7/00 ,  C12N2770/24121 ,  C12N2770/24122 ,  Y02A50/394

摘要： The invention relates to a neuroinvasive and neurovirulent strain of the West Nile virus, known as IS-98-ST1, nucleic acid molecules originating from the genome thereof, proteins and peptides coded by said nucleic acid molecules. The invention also relates to the applications of same.

公开(公告)号：EP2001900A2

公开(公告)日：2008-12-17

申请号：EP07734896.9

申请日：2007-03-15

申请人： INSTITUT PASTEUR

发明人： DESPRES, Philippe ,  BREHIN, Anne-Claire ,  MARECHAL, Valérie ,  CHARNEAU, Pierre ,  SOUQUE, Philippe

IPC分类号： C07K14/18

CPC分类号： G01N33/56983 ,  A61K38/00 ,  A61K39/00 ,  C07K14/005 ,  C07K16/1081 ,  C12N7/00 ,  C12N2770/36121 ,  C12N2770/36122 ,  C12N2770/36131 ,  G01N2333/181 ,  G01N2800/32 ,  Y02A50/383 ,  Y02A50/51

摘要： The present invention concerns wild-strains of Chikungunya virus isolated from patients exhibiting severe forms of infection and stemming from a human arbovirosis epidemy. The present invention also concerns polypeptide sequences and fragment thereof derived from their genome, the polynucleotide encoding same and their use as diagnostic products, as vaccine and/or as immunogenic compositions.

公开(公告)号：EP1893228A2

公开(公告)日：2008-03-05

申请号：EP06778626.9

申请日：2006-06-20

申请人： INSTITUT PASTEUR ,  Centre National de la Recherche Scientifique

发明人： TANGY, Frédéric ,  LUCAS-HOURANI, Marianne ,  NAVARRO-SANCHEZ, Erika ,  FRENKIEL, Marie-Pascale ,  BEDOUELLE, Hugues ,  COMBREDET, Chantal ,  DESPRES, Philippe

IPC分类号： A61K38/16 ,  C07K14/18 ,  C12N15/09 ,  C12N15/62 ,  C12N15/86 ,  C07K16/10

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/12 ,  A61K39/165 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/55 ,  A61K2039/55505 ,  C07K2319/00 ,  C07K2319/04 ,  C12N7/00 ,  C12N15/86 ,  C12N2760/18434 ,  C12N2760/18443 ,  C12N2770/24122 ,  C12N2770/24134 ,  C12N2770/24171 ,  Y02A50/386 ,  Y02A50/388 ,  Y02A50/39 ,  Y02A50/394

摘要： The invention relates to building a chimeric polypeptide used for preventing or treating a Flaviviridae infection. The use of the inventive chimeric polypeptide for producing recombinant viral vectors such as a measles living viral vector is also disclosed.

公开(公告)号：EP1311539A2

公开(公告)日：2003-05-21

申请号：EP01961004.7

申请日：2001-06-18

申请人： INSTITUT PASTEUR

发明人： DESPRES, Philippe ,  COURAGEOT, Marie-Pierre ,  DEUBEL, Vincent ,  CATTEAU, Adeline

IPC分类号： C07K14/18

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C12N2770/24122 ,  Y02A50/386 ,  Y02A50/394

摘要： The present invention relates to pro-apoptotic fragments of the Dengue virus pRM and E glycoproteins, methods of screening for molecules capable of inducing apoptosis and methods of inducing apoptosis in a cell.