公开(公告)号：EP2374816A1

公开(公告)日：2011-10-12

申请号：EP10305353.4

申请日：2010-04-07

申请人： Humalys ,  Singapore Immunology Network (SlgN)

发明人： Warter, Lucile ,  Abastado, Jean-Pierre ,  Nardin, Alessandra ,  Wang, Cheng-I

IPC分类号： C07K16/10 ,  C12N15/13 ,  C12N5/12 ,  A61K39/395

CPC分类号： C07K16/1081 ,  A61K2039/505 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  G01N2333/181 ,  Y02A50/383

摘要： The invention relates to binding molecules against Chikungunya virus, which are able of neutralizing Chikungunya virus infectivity, and which can be used with therapeutic, diagnosis or research purposes, as well as to a pharmaceutical composition comprising said binding molecules.

摘要翻译： 本发明涉及能够中和基孔肯雅病毒感染性并可用于治疗，诊断或研究目的的基孔肯雅病毒的结合分子以及包含所述结合分子的药物组合物。

公开(公告)号：EP2720715A1

公开(公告)日：2014-04-23

申请号：EP12741389.6

申请日：2012-06-18

申请人： Bharat Biotech International Limited

发明人： ELLA, Krishna Murthy ,  KANDASWAMY, Sumathy

IPC分类号： A61K39/12 ,  C07K14/18

CPC分类号： A61K39/12 ,  A61K2039/5252 ,  A61K2039/55505 ,  A61K2039/55566 ,  A61K2039/55583 ,  A61K2039/70 ,  C12N2770/24134 ,  C12N2770/36121 ,  C12N2770/36122 ,  C12N2770/36123 ,  C12N2770/36134 ,  G01N2333/181 ,  G01N2333/185 ,  G01N2469/20 ,  G01N2800/26 ,  Y02A50/383 ,  Y02A50/39

摘要： A vaccine composition for prophylaxis and treatment of Chikungunya virus infections is disclosed which is capable of conferring immunity against any genotypic variants of the Chikungunya virus. More particularly the invention discloses particular nucleotide sequences and their translated proteins thereof, which may be expressed as Virus Like Particles which for use as a vaccine antigens against Chikungunya virus infections. The compositions disclosed in this invention are also protective against any genotypic variants of the Chikungunya virus which may be propagated by any suitable vector of the disease including Aedis albopictus and Aedis aegypti.

公开(公告)号：EP3283101A2

公开(公告)日：2018-02-21

申请号：EP16780715.5

申请日：2016-04-14

申请人： Vanderbilt University

发明人： CROWE, James, E. ,  SMITH, Scott, A. ,  DERMODY, Terence ,  SILVA, Laurie

IPC分类号： A61K39/00 ,  A61K39/395 ,  C07K16/10 ,  C12N5/12 ,  C12N15/13

CPC分类号： C07K16/1081 ,  A61K39/00 ,  A61K39/12 ,  A61K39/395 ,  A61K2039/505 ,  A61K2039/507 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C12Q1/70 ,  G01N33/56983 ,  G01N2333/181 ,  Y02A50/383 ,  Y02A50/51

摘要： The present disclosure is directed to antibodies binding to and neutralizing Chikungunya virus (CHIKV) and methods for use thereof.

公开(公告)号：EP2374816B1

公开(公告)日：2016-09-28

申请号：EP10305353.4

申请日：2010-04-07

申请人： Agency for Science, Technology and Research

发明人： Warter, Lucile ,  Abastado, Jean-Pierre ,  Nardin, Alessandra ,  Wang, Cheng-I

IPC分类号： A61K39/00 ,  C07K16/10

CPC分类号： C07K16/1081 ,  A61K2039/505 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  G01N2333/181 ,  Y02A50/383

摘要： The invention relates to binding molecules against Chikungunya virus, which are able of neutralizing Chikungunya virus infectivity, and which can be used with therapeutic, diagnosis or research purposes, as well as to a pharmaceutical composition comprising said binding molecules.

公开(公告)号：EP2720715B1

公开(公告)日：2017-08-09

申请号：EP12741389.6

申请日：2012-06-18

申请人： Bharat Biotech International Limited

发明人： ELLA, Krishna Murthy ,  KANDASWAMY, Sumathy

IPC分类号： A61K39/12 ,  C07K14/18

CPC分类号： A61K39/12 ,  A61K2039/5252 ,  A61K2039/55505 ,  A61K2039/55566 ,  A61K2039/55583 ,  A61K2039/70 ,  C12N2770/24134 ,  C12N2770/36121 ,  C12N2770/36122 ,  C12N2770/36123 ,  C12N2770/36134 ,  G01N2333/181 ,  G01N2333/185 ,  G01N2469/20 ,  G01N2800/26 ,  Y02A50/383 ,  Y02A50/39

摘要： A vaccine composition for prophylaxis and treatment of Chikungunya virus infections is disclosed which is capable of conferring immunity against any genotypic variants of the Chikungunya virus. More particularly the invention discloses particular nucleotide sequences and their translated proteins thereof, which may be expressed as Virus Like Particles which for use as a vaccine antigens against Chikungunya virus infections. The compositions disclosed in this invention are also protective against any genotypic variants of the Chikungunya virus which may be propagated by any suitable vector of the disease including Aedis albopictus and Aedis aegypti.

摘要翻译： 公开了用于预防和治疗基孔肯雅病毒感染的疫苗组合物，其能够赋予针对基孔肯雅病毒的任何基因型变体的免疫性。 更具体地说，本发明公开了特定的核苷酸序列及其翻译的蛋白质，其可以表达为用作针对基孔肯雅病毒感染的疫苗抗原的病毒样颗粒。 本发明公开的组合物还可以保护免受基孔肯雅病毒的任何基因型变体的侵袭，所述基孔肯雅病毒可以通过包括白纹伊蚊和埃及伊蚊在内的任何合适的疾病载体繁殖。

公开(公告)号：EP2001900B1

公开(公告)日：2015-04-29

申请号：EP07734896.9

申请日：2007-03-15

申请人： INSTITUT PASTEUR

发明人： DESPRES, Philippe ,  BREHIN, Anne-Claire ,  MARECHAL, Valérie ,  CHARNEAU, Pierre ,  SOUQUE, Philippe

IPC分类号： C07K14/18

CPC分类号： G01N33/56983 ,  A61K38/00 ,  A61K39/00 ,  C07K14/005 ,  C07K16/1081 ,  C12N7/00 ,  C12N2770/36121 ,  C12N2770/36122 ,  C12N2770/36131 ,  G01N2333/181 ,  G01N2800/32 ,  Y02A50/383 ,  Y02A50/51

摘要： The present invention concerns wild-strains of Chikungunya virus isolated from patients exhibiting severe forms of infection and stemming from a human arbovirosis epidemy. The present invention also concerns polypeptide sequences and fragment thereof derived from their genome, the polynucleotide encoding same and their use as diagnostic products, as vaccine and/or as immunogenic compositions.

公开(公告)号：EP2460822A3

公开(公告)日：2012-09-26

申请号：EP12153717.9

申请日：2007-03-15

申请人： INSTITUT PASTEUR

发明人： Despres, Philippe ,  Brehin, Anne-Claire ,  Marechal, Valérie ,  Charneau, Pierre ,  Souque, Philippe

IPC分类号： C07K14/18 ,  C12N7/00 ,  G01N33/569 ,  C07K14/005

CPC分类号： G01N33/56983 ,  A61K38/00 ,  A61K39/00 ,  C07K14/005 ,  C07K16/1081 ,  C12N7/00 ,  C12N2770/36121 ,  C12N2770/36122 ,  C12N2770/36131 ,  G01N2333/181 ,  G01N2800/32 ,  Y02A50/383 ,  Y02A50/51

摘要： The present invention concerns wild-strains of Chikungunya virus isolated from patients exhibiting severe forms of infection and stemming from a human arbovirosis epidemy. The present invention also concerns polypeptide sequences and fragment thereof derived from their genome, the polynucleotide encoding same and their use as diagnostic products, as vaccine and/or as immunogenic compositions.

公开(公告)号：EP2460822A2

公开(公告)日：2012-06-06

申请号：EP12153717.9

申请日：2007-03-15

申请人： INSTITUT PASTEUR

发明人： Despres, Philippe ,  Brehin, Anne-Claire ,  Marechal, Valérie ,  Charneau, Pierre ,  Souque, Philippe

IPC分类号： C07K14/18 ,  C12N7/00 ,  G01N33/569

CPC分类号： G01N33/56983 ,  A61K38/00 ,  A61K39/00 ,  C07K14/005 ,  C07K16/1081 ,  C12N7/00 ,  C12N2770/36121 ,  C12N2770/36122 ,  C12N2770/36131 ,  G01N2333/181 ,  G01N2800/32 ,  Y02A50/383 ,  Y02A50/51

摘要： The present invention concerns wild-strains of Chikungunya virus isolated from patients exhibiting severe forms of infection and stemming from a human arbovirosis epidemy. The present invention also concerns polypeptide sequences and fragment thereof derived from their genome, the polynucleotide encoding same and their use as diagnostic products, as vaccine and/or as immunogenic compositions.

摘要翻译： 本发明涉及从患者参展感染的严重形式和来自人arbovirosis epidemy词干分离屈曲病毒的野生菌株。 因此，本发明关注的多肽序列和其片段从它们的基因组，所述多核苷酸编码相同和它们作为诊断产品使用衍生，如疫苗和/或免疫原性组合物作为。

公开(公告)号：EP2001900A2

公开(公告)日：2008-12-17

申请号：EP07734896.9

申请日：2007-03-15

申请人： INSTITUT PASTEUR

发明人： DESPRES, Philippe ,  BREHIN, Anne-Claire ,  MARECHAL, Valérie ,  CHARNEAU, Pierre ,  SOUQUE, Philippe

IPC分类号： C07K14/18

CPC分类号： G01N33/56983 ,  A61K38/00 ,  A61K39/00 ,  C07K14/005 ,  C07K16/1081 ,  C12N7/00 ,  C12N2770/36121 ,  C12N2770/36122 ,  C12N2770/36131 ,  G01N2333/181 ,  G01N2800/32 ,  Y02A50/383 ,  Y02A50/51

摘要： The present invention concerns wild-strains of Chikungunya virus isolated from patients exhibiting severe forms of infection and stemming from a human arbovirosis epidemy. The present invention also concerns polypeptide sequences and fragment thereof derived from their genome, the polynucleotide encoding same and their use as diagnostic products, as vaccine and/or as immunogenic compositions.