公开(公告)号：EP2763696B1

公开(公告)日：2018-09-19

申请号：EP12781027.3

申请日：2012-10-05

申请人： iSD Immunotech ApS

发明人： RYTTERGÅRD DUCH, Mogens ,  BAHRAMI, Shervin

IPC分类号： A61K39/12 ,  C07K4/02 ,  C07K14/08

CPC分类号： C07K14/005 ,  A61K39/12 ,  C07K1/00 ,  C07K4/02 ,  C07K7/08 ,  C07K14/08 ,  C12N7/00 ,  C12N2760/12121 ,  C12N2760/12122 ,  C12N2760/12221 ,  C12N2760/12222 ,  C12N2760/16121 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16221 ,  C12N2760/16222 ,  C12N2760/16234 ,  C12N2760/16321 ,  C12N2760/16322 ,  C12N2770/24121 ,  C12N2770/24122 ,  C12N2770/24134 ,  C12N2770/24221 ,  C12N2770/24222 ,  C12N2770/24234 ,  C12N2770/24321 ,  C12N2770/24322 ,  C12N2770/28021 ,  C12N2770/28034 ,  C12N2770/36121 ,  C12N2770/36122 ,  C12N2770/36221 ,  C12N2770/36222

摘要： The present invention relates to enveloped RNA viruses. The invention in particular relates to the generation of superior antigens for mounting an immune response by first identifying then mutating the immunosuppressive domains in fusion proteins of enveloped RNA viruses resulting in decreased immunosuppressive properties of viral envelope proteins from the viruses.

公开(公告)号：EP1907535A2

公开(公告)日：2008-04-09

申请号：EP06778633.5

申请日：2006-06-21

申请人： INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA)

发明人： LEBERRE, Monique ,  MORIETTE, Coralie ,  BREMONT, Michel

IPC分类号： C12N7/00

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K2039/53 ,  A61K2039/552 ,  C12N7/00 ,  C12N15/1131 ,  C12N15/86 ,  C12N2310/121 ,  C12N2310/127 ,  C12N2770/36121 ,  C12N2770/36122 ,  C12N2770/36134 ,  C12N2770/36151

摘要： The invention concerns recombinant DNA's comprising cDNA of genomic RNA of a Salmonidae alphavirus preceded by a spacer sequence, under the control of a suitable promoter. Said recombinant DNA's are useful for obtaining expression vectors, producing recombinant Salmonidae alphavirus, and for obtaining vaccines.

公开(公告)号：EP0712926A2

公开(公告)日：1996-05-22

申请号：EP95202771.2

申请日：1995-10-13

申请人： Akzo Nobel N.V.

发明人： McLoughlin, Marian F. ,  Nelson, Robert Thomas

IPC分类号： C12N7/00 ,  C07K14/18 ,  C12N15/40 ,  C12N7/02 ,  A61K39/12 ,  G01N33/48

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K39/12 ,  A61K2039/5252 ,  A61K2039/552 ,  C12N7/00 ,  C12N2720/10022 ,  C12N2720/10034 ,  C12N2770/36022 ,  C12N2770/36121 ,  C12N2770/36122 ,  C12N2770/36134 ,  G01N33/56983

摘要： There is described a novel virus which is the causative agent of fish pancreatic disease, which is a serious disease affecting Atlantic salmon. A method of isolating the virus through co-cultivation of infected tissues following by passage is described and an isolated strain of the virus has been deposited.
The use of the virus, or proteins or polypeptide derived therefrom as a vaccine or in diagnosis is described, together with genetically engineered constructs.

摘要翻译： 描述了一种新型病毒，它是影响大西洋鲑鱼的严重疾病鱼胰腺疾病的病原体。 描述通过传代后感染组织的共同培养来分离病毒的方法，并且已经沉积了病毒的分离菌株。 描述病毒或其衍生自其的蛋白质或多肽作为疫苗或诊断的用途，以及遗传工程构建体。

公开(公告)号：EP1907535B1

公开(公告)日：2012-09-12

申请号：EP06778633.5

申请日：2006-06-21

申请人： INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA)

发明人： LEBERRE, Monique ,  MORIETTE, Coralie ,  BREMONT, Michel

IPC分类号： C12N7/00 ,  C12N15/86 ,  A61K39/12 ,  C07K14/18 ,  C12N15/113

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K2039/53 ,  A61K2039/552 ,  C12N7/00 ,  C12N15/1131 ,  C12N15/86 ,  C12N2310/121 ,  C12N2310/127 ,  C12N2770/36121 ,  C12N2770/36122 ,  C12N2770/36134 ,  C12N2770/36151

公开(公告)号：EP1997900A3

公开(公告)日：2010-10-06

申请号：EP08075018.5

申请日：1997-04-04

申请人： Novartis Vaccines and Diagnostics, Inc. ,  Washington University

发明人： Dubensky, Thomas W., Jr. ,  Polo, John M. ,  Belli, Barbara A. ,  Schlesinger, Sondra ,  Dryga, Sergey A. ,  Frolov, Ilya

IPC分类号： C12N15/86 ,  C07K14/18 ,  C12N7/04 ,  C12N7/00

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K48/00 ,  C12N7/00 ,  C12N15/86 ,  C12N2770/36121 ,  C12N2770/36122 ,  C12N2770/36143 ,  C12N2770/36162 ,  C12N2830/003 ,  C12N2830/006 ,  C12N2830/15 ,  C12N2830/32 ,  C12N2830/42 ,  C12N2830/48 ,  C12N2840/203 ,  C12N2840/44

摘要： Isolated nucleic acid molecules are disclosed, comprising an alphavirus nonstructural protein gene which, when operably incorporated into a recombinant alphavirus particle, eukaryotic layered vector initiation system, or RNA vector replicon, has a reduced level of vector-specific RNA synthesis, as compared to wild-type, and the same or greater level of proteins encoded by RNA transcribed from the viral junction region promoter, as compared to a wild-type recombinant alphavirus particle. Also disclosed are RNA vector replicons, alphavirus vector constructs, and eukaryotic layered vector initiation systems which contain the above-identified nucleic acid molecules.

公开(公告)号：EP1029068A2

公开(公告)日：2000-08-23

申请号：EP98953276.7

申请日：1998-10-06

申请人： CHIRON CORPORATION ,  WASHINGTON UNIVERSITY

发明人： DUBENSKY, Thomas, W., Jr. ,  POLO, John, M. ,  BELLI, Barbara, A. ,  SCHLESINGER, Sondra ,  DRYGA, Sergey, A. ,  FROLOV, Ilya

IPC分类号： C12N15/86 ,  C12N15/40 ,  C12N7/01 ,  C12N15/79 ,  C12N5/10 ,  A61K48/00

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K48/00 ,  C12N7/00 ,  C12N15/79 ,  C12N15/86 ,  C12N2770/36121 ,  C12N2770/36122 ,  C12N2770/36143 ,  C12N2770/36162 ,  C12N2830/005 ,  C12N2830/006 ,  C12N2830/42 ,  C12N2830/48 ,  C12N2840/20 ,  C12N2840/203 ,  C12N2840/44

摘要： Isolated nucleic acid molecules are disclosed, comprising an alphavirus nonstructural protein gene which, when operably incorporated into a recombinant alphavirus particle, eukaryotic layered vector initiation system, or RNA vector replicon, has a reduced level of vector-specific RNA synthesis, as compared to wild-type, and the same or greater level of proteins encoded by RNA transcribed from the viral junction region promoter, as compared to a wild-type recombinant alphavirus particle. Also disclosed are RNA vector replicons, alphavirus vector constructs, and eukaryotic layered vector initiation systems which contain the above-identified nucleic acid molecules.

公开(公告)号：EP2519266B1

公开(公告)日：2017-07-26

申请号：EP11728540.3

申请日：2011-01-03

申请人： Medigen, Inc.

发明人： PUSHKO, Peter ,  TRETYAKOVA, Irina ,  LUKASHEVICH, Igor

IPC分类号： A61K39/12 ,  C12N7/00

CPC分类号： A61K39/12 ,  A61K49/0004 ,  A61K2039/5254 ,  A61K2039/53 ,  C07K14/005 ,  C12N7/00 ,  C12N2770/36121 ,  C12N2770/36122 ,  C12N2770/36134 ,  C12N2770/36151 ,  Y02A50/383

摘要： Described herein are i-DNA™ vectors and vaccines and methods for using the same. The i-DNA™ generates live attenuated vaccines in eukaryotic cells in vitro or in vivo for pathogenic RNA viruses, particularly chikungunya virus (CHIKV). When iDNA is injected into the vaccine recipient, RNA of live attenuated virus is generated by in vivo transcription in the recipient's tissues. This initiates production of progeny attenuated viruses in the tissues of the vaccine recipient, as well as elicitation of an effective immune response protecting against wild-type, non-attenuated virus.

摘要翻译： 本文描述了i-DNA™载体和疫苗以及使用它们的方法。 i-DNA™在真核细胞中体外或体内产生致病RNA病毒，特别是基孔肯雅病毒（CHIKV）的减毒活疫苗。 当iDNA被注射到疫苗接受者体内时，活的减毒病毒的RNA通过在受体组织中的体内转录产生。 这启动了疫苗接受者组织中子代减毒病毒的产生，以及引发针对野生型非减毒病毒的有效免疫应答。

公开(公告)号：EP0907746A2

公开(公告)日：1999-04-14

申请号：EP97922294.0

申请日：1997-04-04

申请人： CHIRON CORPORATION ,  WASHINGTON UNIVERSITY

发明人： DUBENSKY, Thomas, W., Jr. ,  POLO, John, M. ,  BELLI, Barbara, A. ,  SCHLESINGER, Sondra ,  DRYGA, Sergey A. ,  FROLOV, Ilya

IPC分类号： C12N15 ,  C07K14 ,  C12N5 ,  C12N7 ,  C12P21 ,  A61K39 ,  A61K48

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K48/00 ,  C12N7/00 ,  C12N15/86 ,  C12N2770/36121 ,  C12N2770/36122 ,  C12N2770/36143 ,  C12N2770/36162 ,  C12N2830/003 ,  C12N2830/006 ,  C12N2830/15 ,  C12N2830/32 ,  C12N2830/42 ,  C12N2830/48 ,  C12N2840/203 ,  C12N2840/44

摘要： Isolated nucleic acid molecules are disclosed, comprising an alphavirus nonstructural protein gene which, when operably incorporated into a recombinant alphavirus particle, eukaryotic layered vector initiation system, or RNA vector replicon, has a reduced level of vector-specific RNA synthesis, as compared to wild-type, and the same or greater level of proteins encoded by RNA transcribed from the viral junction region promoter, as compared to a wild-type recombinant alphavirus particle. Also disclosed are RNA vector replicons, alphavirus vector constructs, and eukaryotic layered vector initiation systems which contain the above-identified nucleic acid molecules.

公开(公告)号：EP0755440A4

公开(公告)日：1998-08-19

申请号：EP95914815

申请日：1995-03-21

申请人： RES DEV FOUNDATION

发明人： BROWN DENNIS T

IPC分类号： C12N15/09 ,  A61K31/00 ,  A61K31/095 ,  A61K31/70 ,  A61K39/00 ,  A61K39/12 ,  A61P31/12 ,  C07H21/04 ,  C07K14/18 ,  C12N5/10 ,  C12N7/00 ,  C12N15/33 ,  C12N15/50 ,  C12R1/93 ,  C12N1/19 ,  C12N1/21

CPC分类号： C12N7/00 ,  A61K31/00 ,  A61K31/095 ,  A61K39/00 ,  C07K14/005 ,  C12N2770/36121 ,  C12N2770/36122

公开(公告)号：EP0712926A3

公开(公告)日：1996-07-03

申请号：EP95202771.2

申请日：1995-10-13

申请人： Akzo Nobel N.V.

发明人： McLoughlin, Marian F. ,  Nelson, Robert Thomas

IPC分类号： C12N7/00 ,  C07K14/18 ,  C12N15/40 ,  C12N7/02 ,  A61K39/12 ,  G01N33/48

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K39/12 ,  A61K2039/5252 ,  A61K2039/552 ,  C12N7/00 ,  C12N2720/10022 ,  C12N2720/10034 ,  C12N2770/36022 ,  C12N2770/36121 ,  C12N2770/36122 ,  C12N2770/36134 ,  G01N33/56983

摘要： There is described a novel virus which is the causative agent of fish pancreatic disease, which is a serious disease affecting Atlantic salmon. A method of isolating the virus through co-cultivation of infected tissues following by passage is described and an isolated strain of the virus has been deposited. The use of the virus, or proteins or polypeptide derived therefrom as a vaccine or in diagnosis is described, together with genetically engineered constructs.

摘要翻译： 描述了一种新型病毒，它是鱼类胰腺疾病的病原体，它是影响大西洋鲑鱼的严重疾病。 描述了通过随后通过共同培养受感染组织来分离病毒的方法，并且已经沉积了病毒的分离株。 描述了该病毒或由其衍生的蛋白质或多肽作为疫苗或用于诊断的用途，以及基因工程构建体。