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公开(公告)号：EP3740490A1
公开(公告)日：2020-11-25
申请号：EP19703591.8
申请日：2019-01-18
发明人： BLAKE, James F. , DAI, Donghua , HAAS, Julia , JIANG, Yutong , KOLAKOWSKI,, Gabrielle R. , METCALF, Andrew T. , MORENO, David A. , PRIGARO, Brett , REN, Li
IPC分类号： C07D487/04 , A61P35/00 , A61K31/519
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公开(公告)号：EP3322706B1
公开(公告)日：2020-11-11
申请号：EP16741825.0
申请日：2016-07-15
发明人： ANDREWS, Steven W. , BLAKE, James F. , CHICARELLI, Mark J. , GOLOS, Adam , HAAS, Julia , JIANG, Yutong , KOLAKOWSKI, Gabrielle R.
IPC分类号： A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/499 , A61K31/506 , A61K31/5377 , A61K31/55 , C07D519/00 , A61P1/00 , A61P35/04 , A61P43/00 , C07D471/04 , A61P29/00 , A61P35/00
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公开(公告)号：EP3694854A1
公开(公告)日：2020-08-19
申请号：EP18796243.6
申请日：2018-10-10
发明人： METCALF, Andrew T. , FRY, David , MCFADDIN, Elizabeth A. , KOLAKOWSKI, Gabrielle R. , HAAS, Julia , TANG, Tony P. , JIANG, Yutong
IPC分类号： C07D471/04 , A61P35/00 , A61K31/437
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公开(公告)号：EP3595651A1
公开(公告)日：2020-01-22
申请号：EP18716714.3
申请日：2018-03-16
申请人： Array Biopharma Inc.
IPC分类号： A61K31/395 , G01N33/574
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35.发明公开INTERMEDIATE COMPOUNDS FOR THE PREPARATION OFSUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS 审中-公开用于制备作为TRK激酶抑制剂的取代的吡唑并[1,5-A]嘧啶化合物的中间体化合物
公开(公告)号：EP3299372A1
公开(公告)日：2018-03-28
申请号：EP17199899.0
申请日：2010-07-09
发明人： ALLEN, Shelley , ANDREWS, Stephen, S. , CONDROSKI, Kevin Ronald , HAAS, Julia , HUANG, Lily , JIANG, Yutong , KERCHER, Timothy , SEO, Jeongbeob
IPC分类号： C07D487/04 , A61K31/519 , C07D519/00 , C07D498/22 , C07D471/22 , C07D453/02 , A61K31/5377
摘要： Compounds of Formula II, III and IV, wherein R 3 , R 4 , Y and n are defined in the claims.
摘要翻译： 式II，III和IV化合物，其中R3，R4，Y和n如权利要求中所定义。
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36.发明授权SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS 有权作为TRK激酶抑制剂的取代的吡唑并[1,5-a]嘧啶化合物
公开(公告)号：EP2451812B1
公开(公告)日：2017-11-08
申请号：EP10732606.8
申请日：2010-07-09
发明人： ALLEN, Shelley , ANDREWS, Steven S. , CONDROSKI, Kevin Ronald , HAAS, Julia , HUANG, Lily , JIANG, Yutong , KERCHER, Timothy , SEO, Jeongbeob
IPC分类号： C07D487/04 , A61K31/519 , C07D519/00 , C07D453/02 , C07D471/22 , C07D498/22 , A61K31/5377
CPC分类号： C07D487/04 , A61K31/519 , A61K31/5377 , C07D453/02 , C07D471/22 , C07D498/22 , C07D519/00
摘要： Compounds of Formula II, III and IV, wherein R 3 , R 4 , Y and n are defined in the claims.
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公开(公告)号：EP3205654A1
公开(公告)日：2017-08-16
申请号：EP17163978.4
申请日：2011-05-13
发明人： ANDREWS, Steven Wade , CONDROSKI, Kevin Ronald , HAAS, Julia , JIANG, Yutong , KOLAKOWSKI, Gabrielle R. , SEO, Jeongbeob , YANG, Hong-Woon , ZHAO, Qian
IPC分类号： C07D487/04 , A61K31/519 , C07D519/00 , C07D498/22 , C07D487/22 , C07D471/22
CPC分类号： C07D498/22 , A61K31/519 , C07D471/22 , C07D487/04 , C07D487/22 , C07D519/00 , Y02A50/414
摘要： Compounds of Formula I:
and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R 2 , R 2a , R 3 , R 3a , and Z are as defined herein, are inhibitors of Trk kinases and are useful in the treatment of pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.摘要翻译： 其中环A，环B，W，m，D，R2，R2a，R3，R3a和Z如本文所定义的式I化合物及其药学上可接受的盐为Trk激酶的抑制剂并且可用于治疗 疼痛，癌症，炎症，神经退行性疾病和某些传染病。
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38.发明授权PYRROLIDINYL UREA, PYRROLIDINYL THIOUREA AND PYRROLIDINYL GUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS 有权作为TRKA激酶抑制剂的吡咯烷基脲，吡咯烷基硫代脲和吡咯烷基胍的化合物
公开(公告)号：EP2712358B1
公开(公告)日：2016-12-21
申请号：EP12743553.5
申请日：2012-05-09
发明人： ALLEN, Shelley , ANDREWS, Steven, W. , BLAKE, James, F. , CONDROSKI, Kevin, R. , HAAS, Julia , HUANG, Lily , JIANG, Yutong , KERCHER, Timothy , KOLAKOWSKI, Gabrielle R. , SEO, Jeongbeob
IPC分类号： A61K31/4375 , A61K31/454 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377
CPC分类号： C07D403/12 , A61K31/4155 , A61K31/4162 , A61K31/4178 , A61K31/4192 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/4375 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/048 , C07D495/04 , Y02A50/414
摘要： Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, or solvates or prodrugs thereof, where R1, R2, Ra, Rb, Rc, Rd, X, Y, B, and Ring C are as defined herein, and wherein the Y—B moiety and the NH—C(═X)—NH moiety are in the trans configuration, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.
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39.发明授权SUBSTITUTED IMIDAZO[1,2B]PYRIDAZINE COMPOUNDS AS TRK KINASE INHIBITORS 有权替补咪咪唑[1,2B]吡啶并吡啶EN嗪TRK-激酶抑制剂
公开(公告)号：EP2350075B1
公开(公告)日：2014-03-05
申请号：EP09792796.6
申请日：2009-09-21
发明人： ANDREWS, Steven, W. , HAAS, Julia , JIANG, Yutong , ZHANG, Gan
IPC分类号： C07D471/04 , A61K31/5025 , A61P29/00
CPC分类号： C07D487/04 , A61K31/5025 , A61K31/5377 , A61K31/541 , C07C51/412 , C07C53/18 , C07D471/04 , C07D519/00
摘要： Compounds of Formula (I): in which R1, R2, R3, R4, X, Y and n have the meanings given in the specification, are inhibitors of Trk kinases and are useful in the treatment of diseases which can be treated with a Trk kinase inhibitor.
摘要翻译： 其中R1，R2，R3，R4，X，Y和n具有说明书中给出的含义。
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