-
公开(公告)号：EP4216951A1
公开(公告)日：2023-08-02
申请号：EP21873279.0
申请日：2021-09-21
发明人： WANG, Xiaolun , MARX, Matthew Arnold , ALLEN, Shelley , CHICARELLI, Mark Joseph , DAHLKE, Joshua Ryan , DAI, Donghua , FELL, Jay Bradford , FISCHER John, Peter , HILTON, Michael Christopher , KAHN, Dean Russell , MEJIA, Macedonio Junior , NGUYEN, Phong , PAJK, Spencer , RODRIGUEZ, Martha E. , SAVECHENKOV, Pavel Yu , TANG, Tony Pisal
IPC分类号： A61K31/4353 , A61K31/519 , C07D471/04
-
公开(公告)号：EP4021444A1
公开(公告)日：2022-07-06
申请号：EP20859068.7
申请日：2020-08-27
发明人： WANG, Xiaolun , BURNS, Aaron Craig , CHRISTENSEN, James Gail , KETCHAM, John Michael , LAWSON, John David , MARX, Matthew Arnold , SMITH, Christopher Ronald , ALLEN, Shelley , BLAKE, James Francis , CHICARELLI, Mark Joseph , DAHLKE, Joshua Ryan , DAI, Donghua , FELL, Jay Bradford , FISCHER, John Peter , MEJIA, Macedonio J. , NEWHOUSE, Brad , NGUYEN, Phong , O'LEARY, Jacob Matthew , PAJK, Spencer , RODRIGUEZ, Martha E. , SAVECHENKOV, Pavel , TANG, Tony P. , VIGERS, Guy P. A. , ZHAO, Qian , KAHN, Dean Russell , GAUDINO, John , HILTON, Michael Christopher
IPC分类号： A61K31/435 , A61K31/4375 , A61K31/517 , C07D471/00 , C07D471/02 , C07D471/04
-
公开(公告)号：EP3409670A1
公开(公告)日：2018-12-05
申请号：EP17210335.0
申请日：2013-11-12
发明人： ALLEN, Shelley , BRANDHUBER, Barbara, J. , KERCHER, Timothy , KOLAKOWSKI, Gabrielle, R. , WINSKI, Shannon, L.
IPC分类号： C07D403/12 , C07D401/14 , C07D403/14 , A61K31/4155 , A61P35/00 , A61P29/00 , A61P31/00 , A61P27/02
摘要： Compounds of Formula I:
or stereoisomers, tautomers, or pharmaceutically acceptable salts, or solvates or prodrugs thereof, where R 1 , R 2 , R a , R b , R c , R d , X, Ring B, and Ring C are as defined herein, and wherein Ring B and the NH-C(=X)-NH moiety are in the trans configuration, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis or pelvic pain syndrome.-
公开(公告)号：EP3409670B1
公开(公告)日：2020-09-09
申请号：EP17210335.0
申请日：2013-11-12
发明人： ALLEN, Shelley , BRANDHUBER, Barbara, J. , KERCHER, Timothy , KOLAKOWSKI, Gabrielle, R. , WINSKI, Shannon, L.
IPC分类号： C07D403/12 , C07D401/14 , C07D403/14 , A61K31/4155 , A61P35/00 , A61P29/00 , A61P31/00 , A61P27/02
-
5.发明公开N-PYRROLIDINYL, N'-PYRAZOLYL- UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS 有权N-吡咯烷基 - ，N' - 吡唑并 - 硬脂酰 - ，噻唑烷基 - ，胍基 - 联氨基甘氨酸二亚氨基酯TRKA-激酶基因
公开(公告)号：EP2922844A1
公开(公告)日：2015-09-30
申请号：EP13795946.6
申请日：2013-11-12
发明人： ALLEN, Shelley , BRANDHUBER, Barbara, J. , KERCHER, Timothy , KOLAKOWSKI, Gabrielle, R. , WINSKI, Shannon, L.
IPC分类号： C07D403/12 , C07D401/14 , C07D403/14 , A61K31/4155 , A61P35/00 , A61P29/00 , A61P31/00 , A61P27/02
CPC分类号： C07D401/14 , C07D403/12 , C07D403/14
摘要： Compounds of Formula (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts, or solvates or prodrugs thereof, where R1, R2, Ra, Rb, Rc, Rd, X, Ring B, and Ring C are as defined herein, and wherein Ring B and the NH-C(=X)-NH moiety are in the trans configuration, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis or pelvic pain syndrome.
摘要翻译： 其中R 1，R 2，R a，R b，R c，R d，X，环B和环C如本文所定义的式（I）化合物或其立体异构体，互变异构体或其药学上可接受的盐或溶剂合物或前药， 环B和NH-C（= X）-NH部分是反式构型，是TrkA激酶的抑制剂，可用于治疗可用TrkA激酶抑制剂治疗的疾病，例如疼痛，癌症，炎症/ 炎症性疾病，神经变性疾病，某些传染病，干燥综合征，子宫内膜异位症，糖尿病性周围神经病变，前列腺炎或骨盆疼痛综合征。
-
6.发明公开BICYCLIC UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF PAIN 有权疼痛条件的适当双环脲，硫脲，胍和双氰胺的处理
公开(公告)号：EP2920166A1
公开(公告)日：2015-09-23
申请号：EP13795960.7
申请日：2013-11-13
发明人： ALLEN, Shelley , ANDREWS, Steven, Wade , BLAKE, James, F. , BRANDHUBER, Barbara, J. , HAAS, Julia , JIANG, Yutong , KERCHER, Timothy , KOLAKOWSKI, Gabrielle, R. , THOMAS, Allen, A. , WINSKI, Shannon, L.
IPC分类号： C07D401/14 , C07D405/14 , C07D231/40 , C07D231/54 , C07D401/12 , C07D403/02 , C07D403/04 , C07D403/14 , C07D405/12 , C07D413/12 , C07D453/02 , A61K31/4155 , A61K31/416 , A61K31/4162 , A61P25/00
CPC分类号： C07D491/048 , C07D231/40 , C07D231/52 , C07D231/54 , C07D231/56 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/02 , C07D403/04 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D453/02 , C07D471/08
摘要： Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis and pelvic pain syndrome.
-
7.发明公开PYRROLIDINYL UREA, PYRROLIDINYL THIOUREA AND PYRROLIDINYL GUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS 有权作为TRKA激酶抑制剂的吡咯烷基脲，吡咯烷基硫代脲和吡咯烷基胍的化合物
公开(公告)号：EP2712358A2
公开(公告)日：2014-04-02
申请号：EP12743553.5
申请日：2012-05-09
发明人： ALLEN, Shelley , ANDREWS, Steven, W. , BLAKE, James, F. , CONDROSKI, Kevin, R. , HAAS, Julia , HUANG, Lily , JIANG, Yutong , KERCHER, Timothy , KOLAKOWSKI, Gabrielle R. , SEO, Jeongbeob
IPC分类号： C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04 , A61K31/4155 , A61K31/4162 , A61K31/4178 , A61K31/4192 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/4439
CPC分类号： C07D403/12 , A61K31/4155 , A61K31/4162 , A61K31/4178 , A61K31/4192 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/4375 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/048 , C07D495/04 , Y02A50/414
摘要： Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, or solvates or prodrugs thereof, where R1, R2, Ra, Rb, Rc, Rd, X, Y, B, and Ring C are as defined herein, and wherein the Y—B moiety and the NH—C(═X)—NH moiety are in the trans configuration, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.
摘要翻译： 式I化合物或其立体异构体，互变异构体或药学上可接受的盐或溶剂合物或前药：其中R 1，R 2，R a，R b，R c，R d，X，Y，B和环C为 如本文所定义，并且其中YB部分和NH-C（= X）-NH部分处于反式构型，是TrkA激酶的抑制剂并且可用于治疗可用TrkA激酶抑制剂治疗的疾病， 如疼痛，癌症，炎症，神经退行性疾病和某些传染病。
-
公开(公告)号：EP1879886A1
公开(公告)日：2008-01-23
申请号：EP06758821.0
申请日：2006-05-01
发明人： HANS, Jeremy , WALLACE, Eli M. , ZHAO, Qian , ALLEN, Shelley , LAIRD, Ellen , LYSSIKATOS, Joseph P. , ROBINSON, John E. , CORRETTE, Christopher P. , DELISLE, Robert Kirk , VOEGTLI, Walter Charles
IPC分类号： C07D417/04
CPC分类号： C07D513/04 , C07D285/12 , C07D417/04 , C07D417/14 , C07D419/04 , C07D471/04 , C07D487/04 , C07D495/04 , C07D497/04 , C07F9/65395
摘要： This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
-
9.发明公开MITOTIC KINESIN INHIBITORS AND METHODS OF USE THEREOF 有权MITOTISCHE KINESINHEMMER UND VERFAHREN ZU IHRER VERWENDUNG
公开(公告)号：EP1809280A2
公开(公告)日：2007-07-25
申请号：EP05819172.7
申请日：2005-10-18
发明人： HANS, Jeremy , WALLACE, Eli M. , ZHAO, Qian , LYSSIKATOS, Joseph P. , AICHER, Tom , LAIRD, Ellen , ROBINSON, John , ALLEN, Shelley
IPC分类号： A61K31/4245 , C07D417/00 , C07D413/00
CPC分类号： C07D285/12 , C07D271/107 , C07D401/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07F9/201 , C07F9/65392
摘要： This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
摘要翻译： 本发明涉及有丝分裂驱动蛋白抑制剂，特别是KSP，以及生产这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用抑制剂和药物组合物治疗和预防各种疾病的方法。
-
公开(公告)号：EP3564236A1
公开(公告)日：2019-11-06
申请号：EP19163878.2
申请日：2019-03-19
发明人： ALLEN, Shelley , ANDREWS, Steven W. , BAER, Brian , CRANE, Zackary , LIU, Weidong , WATSON, Daniel John
IPC分类号： C07D403/12 , C07D401/14 , C07D405/14 , C07D403/14 , A61K31/4155 , A61K45/06 , A61K9/00 , C07D207/16 , A61K31/506
摘要： Provided is Compound 1
or a pharmaceutically acceptable salt thereof, which is an inhibitor of TrkA kinase and is useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation and inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis, pelvic pain syndrome, diseases related to an imbalance of the regulation of bone remodeling, and diseases resulting from Connective Tissue Growth Factor aberrant signaling.
-
-
-
-
-
-
-
-
-
搜索结果
30 条记录 (耗时 0.046 秒)
