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公开(公告)号：EP2721181B1
公开(公告)日：2019-12-18
申请号：EP12801070.9
申请日：2012-06-15
IPC分类号： C12Q1/6827 , C12Q1/6858 , C12Q1/6883 , C12Q1/6874 , G16B30/00
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公开(公告)号：EP3400312A1
公开(公告)日：2018-11-14
申请号：EP17736421.3
申请日：2017-01-06
发明人： FLAKE, Darl , GUTIN, Alexander , ADAMS, Douglas
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/158
摘要： Panels of biomarkers, methods and systems are disclosed for determining gene expression, and diagnosing and treating melanoma.
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公开(公告)号：EP3327148A1
公开(公告)日：2018-05-30
申请号：EP17194403.6
申请日：2011-06-17
IPC分类号： C12Q1/6886 , C12Q1/6827 , C12N15/11 , C12N5/09 , G06F19/18
CPC分类号： C12Q1/6886 , C12Q1/6827 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G06F19/18 , C12Q2537/16
摘要： This document provides methods and materials involved in assessing samples (e.g., cancer cells) for the presence of a loss of heterozygosity (LOH) signature. For example, methods and materials for determining whether or not a cell (e.g., a cancer cell) contains an LOH signature are provided. Materials and methods for identifying cells (e.g., cancer cells) having a deficiency in homology directed repair (HDR) as well as materials and methods for identifying cancer patients likely to respond to a particular cancer treatment regimen also are provided.
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34.发明公开METHODS AND MATERIALS FOR ASSESSING LOSS OF HETEROZYGOSITY 有权VERFAHREN UND MATERIALIEN ZUR BEWERTUNG DES VERLUSTS DER HETEROZYGOTIE
公开(公告)号：EP3012329A1
公开(公告)日：2016-04-27
申请号：EP15189527.3
申请日：2011-06-17
申请人： Myriad Genetics, Inc. , Abkevich, Victor , Gutin, Alexander , Timms, Kirsten , Lanchbury, Jerry
CPC分类号： C12Q1/6886 , C12Q1/6827 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G06F19/18 , C12Q2537/16
摘要： This document provides methods and materials involved in assessing samples (e.g., cancer cells) for the presence of a loss of heterozygosity (LOH) signature. For example, methods and materials for determining whether or not a cell (e.g., a cancer cell) contains an LOH signature are provided. Materials and methods for identifying cells (e.g., cancer cells) having a deficiency in homology directed repair (HDR) as well as materials and methods for identifying cancer patients likely to respond to a particular cancer treatment regimen also are provided.
摘要翻译： 本文件提供了评估样品（例如癌细胞）中存在杂合性（LOH）特征丧失的方法和材料。 例如，提供了用于确定细胞（例如癌细胞）是否含有LOH特征的方法和材料。 还提供了用于鉴定具有同源性定向修复（HDR）缺陷的细胞（例如癌细胞）的材料和方法以及用于鉴定可能对特定癌症治疗方案作出反应的癌症患者的材料和方法。
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公开(公告)号：EP2739753A2
公开(公告)日：2014-06-11
申请号：EP12819493.3
申请日：2012-08-03
申请人： Myriad Genetics, Inc. , Gutin, Alexander , Jammulapati, Srikanth , Wagner, Susanne , Reid, Julia E. , Flake, Darl
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158
摘要： Biomarkers, particularly hypoxia-related genes, and methods using the biomarkers for molecular detection and classification of disease are provided.
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公开(公告)号：EP2721181A2
公开(公告)日：2014-04-23
申请号：EP12801070.9
申请日：2012-06-15
摘要： Methods and systems for detecting allelic imbalance using nucleic acid sequencing are provided.
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公开(公告)号：EP2475790A1
公开(公告)日：2012-07-18
申请号：EP10816163.9
申请日：2010-09-10
申请人： Myriad Genetics, Inc. , Board of Regents of the University of Texas System , Stone, Steve , Gutin, Alexander , Flake, Darl , Esteva, Francisco , Yu, Dihua
发明人： STONE, Steven , GUTIN, Alexander , FLAKE, Darl , ESTEVA, Francisco , YU, Dihua
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158
摘要： The invention generally relates to molecular diagnostics, and particularly to molecular markers for cancer therapy response and methods of use thereof.
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公开(公告)号：EP2382331A1
公开(公告)日：2011-11-02
申请号：EP10729525.5
申请日：2010-01-07
发明人： STONE, Steve , GUTIN, Alexander , WAGNER, Susanne , REID, Julia
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/154 , C12Q2600/158 , C12Q2600/178 , G01N33/574 , G01N2800/56
摘要： Biomarkers and methods using the biomarkers for the prediction of the recurrence risk of cancer in a patient are provided.
摘要翻译： 提供了使用生物标志物预测患者癌症复发风险的生物标志物和方法。
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39.发明公开
公开(公告)号：EP4444914A1
公开(公告)日：2024-10-16
申请号：EP22905049.7
申请日：2022-12-06
IPC分类号： C12Q1/6886 , G01N33/574
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