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31.发明公开DIARYL UREA DERIVATIVES IN THE TREATMENT OF PROTEIN KINASE DEPENDENT DISEASES 审中-公开蛋白激酶依赖性疾病治疗的二芳基脲衍生物
公开(公告)号：EP1689376A2
公开(公告)日：2006-08-16
申请号：EP04798101.4
申请日：2004-11-26
申请人： Novartis AG , Novartis Pharma GmbH
发明人： BOLD, Guido , CARAVATTI, Giorgio , FLOERSHEIMER, Andreas , GUAGNANO, Vito , IMBACH, Patricia , MASUYA, Keiichi , ROESEL, Johannes , VAUPEL, Andrea , GARCIA-ECHEVERRIA, Carlos
IPC分类号： A61K31/00
CPC分类号： C04B35/632 , C07D239/34 , C07D239/47 , C07D401/12 , C07D403/12
摘要： The invention relates to the use of diaryl urea derivatives for the manufacture of pharmaceutical compositions for the treatment of RET dependent disorders, especially RET dependent tumor diseases. The invention further relates to novel N-[4-(pyrimidin-4-yloxy)-phenyl]-N’-phenyl-urea derivatives and their use in the treatment of the animal or human body, especially in the treatment of a protein kinase dependent disease, to pharmaceutical compositions comprising such novel N-[4-pyrimidin-4-yloxy)-phenyl]-N’-phenyl-urea derivatives and to the use of such novel N-[4-(pyrimidin-4-yloxy)-phenyl]-N’-phenyl-urea derivatives for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as tumour diseases.
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公开(公告)号：EP1572686A1
公开(公告)日：2005-09-14
申请号：EP03785795.0
申请日：2003-12-11
申请人： Novartis AG , Novartis Pharma GmbH
IPC分类号： C07D409/04 , C07D213/64 , C07D405/04 , C07D417/04 , C07D213/74 , C07D401/12 , C07D213/61 , C07D213/38 , C07D213/50 , A61K31/443 , A61K31/4436 , A61K31/4439 , A61K31/4412 , A61K31/44 , A61P35/00
CPC分类号： C07D405/04 , C07D213/38 , C07D213/50 , C07D213/61 , C07D213/64 , C07D213/74 , C07D401/12 , C07D409/04 , C07D417/04
摘要： The present invention relates to new anthranilic acid amide derivatives, processes for the preparation thereof, the application thereof in a process for the treatment of the human or animal body, the use thereof - alone or in combination with one or more other pharmaceutically active compounds.
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公开(公告)号：EP0929553B1
公开(公告)日：2005-03-16
申请号：EP97911163.0
申请日：1997-09-30
申请人： Novartis AG , Novartis Pharma GmbH
发明人： BOLD, Guido , FREI, Jörg , LANG, Marc , TRAXLER, Peter
IPC分类号： C07D487/04 , A61K31/505
CPC分类号： C07D487/04
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34.发明公开OXAZOLO-AND FUROPYRIMIDINES AND THEIR USE IN MEDICAMENTS AGAINST TUMORS 有权唑及其作为药物FUROPYRIMIDINE和抗肿瘤
公开(公告)号：EP1390371A1
公开(公告)日：2004-02-25
申请号：EP02740590.1
申请日：2002-05-13
申请人： Novartis AG , Novartis Pharma GmbH
IPC分类号： C07D498/04 , C07D493/04 , A61K31/519 , A61P35/00
CPC分类号： C07D491/04
摘要： The invention relates to pharmaceutically acceptable compounds of formula I, wherein the radicals have the significances given in the description. Compounds of formula I are useful against tumor diseases.
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公开(公告)号：EP1140944B1
公开(公告)日：2003-08-27
申请号：EP99969216.3
申请日：1999-12-20
申请人： Novartis AG , Novartis Pharma GmbH
IPC分类号： C07D493/04 , C07D491/04 , C07D413/04 , C07D417/04 , C07D405/04 , C07D401/04 , C07D403/04 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/4709 , A61P35/00
CPC分类号： C07D405/04 , C07D413/04 , C07D417/04 , C07D493/04
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