-
1.发明授权INTERMEDIATES FOR THE SYNTHESIS OF EPOTHILONES AND METHODS FOR THEIR PREPARATION 有权中间体埃博霉素用于合成和方法及其
公开(公告)号：EP1080082B1
公开(公告)日：2004-10-06
申请号：EP99952092.7
申请日：1999-05-14
申请人： Novartis AG , Novartis Pharma GmbH
IPC分类号： C07D277/24 , C07F7/18 , C07D307/32 , C07D417/06 , C07D263/32
CPC分类号： C07D307/33 , C07D263/26 , C07D263/32 , C07D277/24 , C07D319/06 , C07D417/06 , C07F7/1852 , C07F7/1856 , Y02P20/55
摘要： The invention relates to a method of synthesis for a compound of formula (I), wherein R is a heterocyclyl moiety and X1, X2, X3 and X4 are, independently of each other, protecting groups, which is appropriate for the synthesis of epothilone B and desoxyepothilone B.
-
公开(公告)号：EP1730138A1
公开(公告)日：2006-12-13
申请号：EP05716085.5
申请日：2005-03-15
申请人： Novartis AG , Novartis Pharma GmbH
发明人： ALTMANN, Karl-Heinz
IPC分类号： C07D405/04 , C07D417/06 , C07D493/04 , A61K31/427 , A61P35/00
CPC分类号： C07D493/04
摘要： Epothilone derivatives of Formula (I) and their use as a pharmaceutical.
-
公开(公告)号：EP1198225B1
公开(公告)日：2006-01-11
申请号：EP00949439.4
申请日：2000-08-02
申请人： Novartis AG , Novartis Pharma GmbH
IPC分类号： A61K9/127 , A61K31/425
CPC分类号： A61K9/127 , A61K9/1271 , A61K31/427
摘要： This invention provides liposomal compositions comprising an epothilone.
-
公开(公告)号：EP0970070B1
公开(公告)日：2004-10-06
申请号：EP98908086.6
申请日：1998-02-11
申请人： Novartis AG , Novartis Pharma GmbH
发明人： BOLD, Guido , FREI, Jörg , TRAXLER, Peter , ALTMANN, Karl-Heinz , METT, Helmut , STOVER, David, Raymond , WOOD, Jeanette
IPC分类号： C07D401/06 , A61K31/50 , C07D401/12 , C07D403/06 , C07D401/14 , C07F5/02 , C07D413/14 , C07D405/14 , C07D471/04
CPC分类号： C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D405/14 , C07D413/14 , C07D471/04
-
公开(公告)号：EP1420780A2
公开(公告)日：2004-05-26
申请号：EP02767418.3
申请日：2002-08-22
申请人： Novartis AG , Novartis Pharma GmbH
发明人： NICOLAOU, Kyriacos, Costa , NAMOTO, Kenji , RITZEN, Andreas , ULVEN, Trond , SHOJI, Mutsuru , ALTMANN, Karl-Heinz
IPC分类号： A61K31/365 , C07D313/00 , C07D417/06 , C07D407/04 , A61P35/02
CPC分类号： C07D495/08 , C07D313/00 , C07D405/06 , C07D405/12 , C07D417/06 , C07D417/12
摘要： The invention relates to cis- and trans-12, 13-cyclopropyl and 12, 13-cyclobutyl epothilones of formula (I) to (IV), wherein Ar is a radical represented by the following structure:, and the other radicals and symbols have the meanings as defined herein; to their chemical synthesis and biological evaluation; their use in the treatment of neoplastic diseases and to pharmaceutical preparations containing such compounds. The compounds described herein are potent tubulin polymerization promoters and cytotoxic agents.
-
公开(公告)号：EP0906329B1
公开(公告)日：2003-10-08
申请号：EP97924997.6
申请日：1997-05-27
申请人： Novartis AG , Novartis Pharma GmbH
CPC分类号： C07H21/00
-
公开(公告)号：EP1140944B1
公开(公告)日：2003-08-27
申请号：EP99969216.3
申请日：1999-12-20
申请人： Novartis AG , Novartis Pharma GmbH
IPC分类号： C07D493/04 , C07D491/04 , C07D413/04 , C07D417/04 , C07D405/04 , C07D401/04 , C07D403/04 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/4709 , A61P35/00
CPC分类号： C07D405/04 , C07D413/04 , C07D417/04 , C07D493/04
-
公开(公告)号：EP1420780B1
公开(公告)日：2008-10-01
申请号：EP02767418.3
申请日：2002-08-22
申请人： Novartis AG , Novartis Pharma GmbH
发明人： NICOLAOU, Kyriacos, Costa , NAMOTO, Kenji , RITZEN, Andreas , ULVEN, Trond , SHOJI, Mutsuru , ALTMANN, Karl-Heinz
IPC分类号： A61K31/365 , C07D313/00 , C07D417/06 , C07D407/04 , A61P35/02
CPC分类号： C07D495/08 , C07D313/00 , C07D405/06 , C07D405/12 , C07D417/06 , C07D417/12
摘要： The invention relates to cis- and trans-12, 13-cyclopropyl and 12, 13-cyclobutyl epothilones of formula (I) to (IV), wherein Ar is a radical represented by the following structure:, and the other radicals and symbols have the meanings as defined herein; to their chemical synthesis and biological evaluation; their use in the treatment of neoplastic diseases and to pharmaceutical preparations containing such compounds. The compounds described herein are potent tubulin polymerization promoters and cytotoxic agents.
-
9.发明公开INTERMEDIATES FOR THE SYNTHESIS OF EPOTHILONES AND METHODS FOR THEIR PREPARATION 有权中间体埃博霉素用于合成和方法及其
公开(公告)号：EP1080082A1
公开(公告)日：2001-03-07
申请号：EP99952092.7
申请日：1999-05-14
IPC分类号： C07D277/24 , C07F7/18 , C07D307/32 , C07D417/06 , C07D263/32
CPC分类号： C07D307/33 , C07D263/26 , C07D263/32 , C07D277/24 , C07D319/06 , C07D417/06 , C07F7/1852 , C07F7/1856 , Y02P20/55
摘要： The invention relates to a method of synthesis for a compound of formula (I), wherein R is a heterocyclyl moiety and X1, X2, X3 and X4 are, independently of each other, protecting groups, which is appropriate for the synthesis of epothilone B and desoxyepothilone B.
-
公开(公告)号：EP0906327A2
公开(公告)日：1999-04-07
申请号：EP97924155.0
申请日：1997-06-03
申请人： Novartis AG
摘要： A compound of formula (I) where B1 is a radical of a nucleoside base, R1 is hydrogen or a hydroxy-protecting group, R2 is hydrogen, hydroxy or a 2' nucleoside-modifying atom or group, R3 is an unsubstituted or substituted C¿1? to C10 alkyl, C2 to C10 alkenyl, C4 to C10 cycloalkylalkyl, C6 to C10 aryl or C7 to C13 aralkyl group, and Z is halogen or a group of formula (II) where R?4 and R5¿ are each independently an unsubstituted or substituted C¿1? to C10 alkyl, C2 to C10 alkenyl, C4 to C10 cycloalkylalkyl, C6 to C10 aryl or C7 to C13 aralkyl group, or R?4¿ is said group and R5 is hydrogen, or R?4 and R5¿ together with the nitrogen atom to which they are attached denote a five- to thirteen-membered heterocyclic ring, or Z is a group of formula (III): Nuc-¿O?-, where Nuc is the residue of a natural or synthetic nucleoside or oligonucleotide after removal of a 5'-hydroxyl group therefrom attached through a 5' methylene thereof to the indicated oxygen atom.
-
-
-
-
-
-
-
-
-
搜索结果
24 条记录 (耗时 0.018 秒)
