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42 条记录 (耗时 0.039 秒)

    NOUVEAUX DERIVES DE (PIPERAZINYL PONTE)-1-ALCANONE ET LEUR UTILISATION COMME INHIBITEURS DE p75
    33.
    发明授权
    NOUVEAUX DERIVES DE (PIPERAZINYL PONTE)-1-ALCANONE ET LEUR UTILISATION COMME INHIBITEURS DE p75 有权
    NOUVEAUX DERIVES DE（哌嗪基戊酸酯）-1-ALCANONE ET LEURUTILIZATION COMME INHIBITEURS DE p75

    公开(公告)号：EP2297148B8

    公开(公告)日：2012-03-28

    申请号：EP09761939.9

    申请日：2009-06-12

    申请人： SANOFI

    发明人： BARONI, Marco ,  BONO, Françoise ,  DELBARY-GOSSART, Sandrine

    IPC分类号： C07D471/08 ,  C07D487/08 ,  A61K31/529 ,  A61P25/00 ,  A61P29/00 ,  A61P35/00

    CPC分类号： C07D471/08

    摘要： The invention relates to derivatives of ((phenyl)-3,6-dihydropyridin-1 yl)- (bridged piperazinyl)-1 -alkanone and ((phenyl)-2,5-dihydro-pyrrol-1 yl)-(bridged piperazinyl)-1 – alkanone derivatives of the general formula (I) where A, B, m, W, n, and R5 are such as defined in Claim 1, to a method for preparing the same, and to the therapeutic application thereof.

    摘要翻译： （（苯基）-3,6-二氢吡啶-1-基） - （桥连哌嗪基）-1-链烷酮和（（苯基）-2,5-二氢 - 吡咯-1-基） - （桥连哌嗪基 ）-1-其中A，B，m，W，n和R5如权利要求1中定义的通式（I）的链烷酮衍生物及其制备方法，及其治疗应用。

    4-ARYL-1-PHENYLALKYL-1,2,3,6-TETRAHYDROPYRIDINES AYANT UNE ACTIVITE NEUROTROPHIQUE ET NEUROPROTECTRICE
    38.
    发明授权
    4-ARYL-1-PHENYLALKYL-1,2,3,6-TETRAHYDROPYRIDINES AYANT UNE ACTIVITE NEUROTROPHIQUE ET NEUROPROTECTRICE 失效
    4-芳基-1-苯基-1,2,3,6-四氢吡啶ALS NEUROTHOPHE和神经保护ACTIVE

    公开(公告)号：EP0837848B1

    公开(公告)日：2002-09-11

    申请号：EP96924023.3

    申请日：1996-06-26

    申请人： SANOFI-SYNTHELABO

    发明人： BADONE, Domenico ,  BARONI, Marco ,  CARDAMONE, Rosanna ,  FOURNIER, Jacqueline ,  GUZZI, Umberto ,  IELMINI, Alessandra

    IPC分类号： C07D211/70 ,  C07D401/04 ,  C07D211/52 ,  A61K31/445

    CPC分类号： C07D401/04 ,  C07D211/52 ,  C07D211/70

    摘要： Compounds of formula (I), wherein Y is -CH- or -N-; R1 is hydrogen, halogen, a CF3 group, (C3-4) alkyl or (C1-4) alkoxyl; R2 is hydrogen, halogen, hydroxyl, a CF3 group, (C3-4) alkyl or (C1-4) alkoxyl; each of R3 and R4 is hydrogen or (C1-3) alkyl; X is (a) (C3-6) alkyl, (C3-6) alkoxyl, (C3-7) carboxyalkyl, (C1-4)alkoxycarbonyl(C3-6)alkyl, (C3-7) carboxyalkoxyl or (C1-4)alkoxycarbonyl(C3-6)alkoxyl; (b) a radical selected from (C3-7) cycloalkyl, (C3-7) cycloalkyloxy, (C3-7) cycloalkylmethyl, (C3-7) cycloalkylamino and cyclohexenyl, said radical being optionally substituted by halogen, hydroxy, (C1-4) alkoxy, carboxy, (C1-4) alkoxycarbonyl, amino, mono- or di-(C1-4)alkylamino; or (c) a group selected from phenyl, phenoxy, phenylamino, N-(C1-3) alkyl-phenylamino, phenylmethyl, phenylethyl, phenylcarbonyl, phenylthio, phenylsulphonyl, phenylsulphinyl or styryl, said group being optionally mono- or polysubstituted on the phenyl group by halogen, CF3, (C1-4)alkyl, (C1-4)alkoxy, cyano, amino, mono- or di-(C1-4)alkylamino, (C1-4)acylamino, carboxy, (C1-4)alkoxycarbonyl, aminocarbonyl, mono- or di-(C1-4)alkylaminocarbonyl, amino(C1-4)alkyl, hydroxy(C1-4)alkyl or halo(C1-4)alkyl; and salts, solvates and quaternary ammonium salts thereof; a method for preparing said compounds; and pharmaceutical compositions containing same, are disclosed. Said compounds have neurotrophic and neuroprotective activity.

    1-PHENYLALKYL-1,2,3,6-TETRAHYDROPYRIDINES POUR LE TRAITEMENT DE LA MALADIE D'ALZHEIMER
    40.
    发明授权
    1-PHENYLALKYL-1,2,3,6-TETRAHYDROPYRIDINES POUR LE TRAITEMENT DE LA MALADIE D'ALZHEIMER 失效
    1-苯基-1,2,3,6-四氢吡啶的阿尔茨海默病的治疗

    公开(公告)号：EP0950048B1

    公开(公告)日：2001-06-27

    申请号：EP97951323.1

    申请日：1997-12-12

    申请人： SANOFI-SYNTHELABO

    发明人： BARONI, Marco ,  CARDAMONE, Rosanna ,  FOURNIER, Jacqueline ,  GUZZI, Umberto

    IPC分类号： C07D211/70 ,  C07D401/04 ,  A61K31/445

    CPC分类号： C07D401/04 ,  C07D211/70

    摘要： The invention concerns compounds of formula (I) in which Y represents -CH- or -N-; R1 represents hydrogen, a halogen, a CF3 group, (C1-C4)alkyl or (C1-C4)alcoxyl; R2 represents a methyl or ethyl group; R3 and R4 each represent hydrogen or a (C1-C3)alkyl; X represents (a) a (C1-C6)alkyl; a (C1-C6)alcoxyl; a (C3-C7)carboxyalkyl; a (C1-C4)alcoxycarbonyl(C1-C6)alkyl; a (C3-C7)carboxyalcoxyl; or a (C1-C4)alcoxycarbonyl(C1-C6)alcoxyl; (b) a radical selected among a (C3-C7)cycloalkyl, (C3-C7)cycloalkyloxy, (C3-C7)cycloalkylmethyl, (C3-C7)cycloalkylamino and cyclohexenyl, said radical can be substituted by a halogen, hydroxy, (C1-C4)alcoxy, carboxy, (C1-C4)alcoxycarbonyl, amino, mono- or di-(C1-C4) alkylamino; or (c) a group selected among a phenyl, phenoxy, phenylamino, N-(C1-C3)alkylphenylamino, phenylmethyl, phenylethyl, phenylcarbonyl, phenylthio, phenylsuphonyl, phenylsulphinyl or styryl, said group can be mono- or poly-substituted by a halogen, CF3, (C1-C4)alkyl, (C1-C4)alcoxy, cyano, amino, mono- or di-(C1-C4)alkylamino, (C1-C4)acylamino, carboxy, (C1-C4)alcoxycarbonyl, aminocarbonyl, mono- or di-(C1-C4)alkylaminocarbonyl, amino(C1-C4)alkyl, hydroxy(C1-C4)alkyl or halogeno(C1-C4)alkyl. The invention also concerns a method for preparing them and the pharmaceutical compositions containing them. These compounds have a neurotrophic and neuroprotecting activity.