公开(公告)号：EP2310383B8

公开(公告)日：2012-04-11

申请号：EP09761938.1

申请日：2009-06-12

申请人： SANOFI

发明人： BARONI, Marco ,  BONO, Françoise ,  DELBARY-GOSSART, Sandrine

IPC分类号： C07D401/14 ,  A61K31/496 ,  A61P35/00 ,  A61P29/00 ,  A61P25/00

CPC分类号： C07D401/14

摘要： The invention relates to derivatives of 4-{2-[phenyl-3,6- dihydro-pyridin-1-yl]-2-oxo-alkyl}-1-piperazin-2-one and 4-{2-[phenyl-2,5-dihydro-pyrrol-1- yl]-2-oxo-alkyl}-1 -piperazin-2-one having general formula (I), wherein: A, B, m, R3 and n are as defined in claim 1. The invention also relates to the preparation thereof and to the therapeutic use of same.

公开(公告)号：EP2315781A2

公开(公告)日：2011-05-04

申请号：EP09784478.1

申请日：2009-07-07

申请人： Sanofi-Aventis

发明人： BAURIN, Nicolas ,  BERNE, Pierre-François ,  BLANCHE, Francis ,  BONO, Françoise ,  CAMERON, Béatrice ,  DABDOUBI, Tarik ,  HERBERT, Corentin ,  MIKOL, Vincent ,  REMY, Elisabeth

IPC分类号： C07K16/28 ,  C12N15/13 ,  C12N5/18 ,  A61K39/395 ,  A61P35/00

CPC分类号： C07K16/2863 ,  A61K2039/505 ,  C07K16/303 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30

摘要： The present invention relates to FGF-R4 receptor-specific antagonist molecules enabling the inhibition of the activity of said receptor. Said antagonists are, particularly, FGF-R4-specific antibodies enabling the inhibition of the activity of said receptor. The present invention also relates to the therapeutic use of said antibodies, particularly in the field of angiogenesis and in the treatment of certain types of cancer.

公开(公告)号：EP2018165A1

公开(公告)日：2009-01-28

申请号：EP07717861.4

申请日：2007-01-12

申请人： Sanofi-Aventis

发明人： BONO, Françoise ,  GUILLO, Nathalie ,  MAFFRAND, Jean-Pierre ,  FONS, Pierre ,  OLSEN, Jacob-Alsboek ,  ANNE-ARCHARD, Gilles

IPC分类号： A61K31/435 ,  A61P9/00 ,  A61P11/00 ,  C07D519/00

CPC分类号： C07D519/00 ,  A61K31/435 ,  A61K47/55 ,  C07D209/02 ,  C07D221/02

摘要： FGF receptor agonist compounds corresponding to the general formula: M1-L-M2 in which M1 and M2, which may be identical or different, each represent, independently of one another, a monomer unit M, and L represents a linker group which covalently links M1 and M2, wherein said monomer unit corresponds to the general formula M which follows: (I). Preparation process and therapeutic use.

公开(公告)号：EP1017385A1

公开(公告)日：2000-07-12

申请号：EP98925747.2

申请日：1998-05-20

申请人： Sanofi-Synthélabo

发明人： BONO, Françoise ,  FOURNIER, Jacqueline ,  HERBERT, Jean-Marc ,  LAMARCHE, Isabelle ,  GUZZI, Umberto

IPC分类号： A61K31/44

CPC分类号： A61K31/4418

摘要： The invention concerns a compound of formula (I) for preparing pharmaceutical compositions designed to increase the proportions of circulating, cellular and extracellular TGF-β1.

公开(公告)号：EP2513088B1

公开(公告)日：2015-07-01

申请号：EP10801663.5

申请日：2010-12-13

申请人： SANOFI

发明人： BARONI, Marco ,  BONO, Françoise ,  DELBARY-GOSSART, Sandrine ,  VERCESI, Valentina

IPC分类号： C07D401/14 ,  C07D403/14 ,  C07D407/14 ,  C07D409/14 ,  C07D495/04 ,  A61K31/496 ,  A61K31/497 ,  A61K31/4995 ,  A61K31/506 ,  A61K31/551 ,  A61P25/00 ,  C07D401/04 ,  C07D407/04 ,  C07D409/04

CPC分类号： C07D487/08 ,  C07D401/04 ,  C07D401/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D495/04

公开(公告)号：EP2513108A1

公开(公告)日：2012-10-24

申请号：EP10801662.7

申请日：2010-12-13

申请人： SANOFI

发明人： BARONI, Marco ,  BONO, Françoise ,  DELBARY-GOSSART, Sandrine ,  VERCESI, Valentina

IPC分类号： C07D471/04 ,  C07D495/04 ,  C07D513/04 ,  A61K31/429 ,  A61K31/381

CPC分类号： C07D487/08 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04

摘要： The disclosure relates to (heterocycle-fused piperidine)-(piperazinyl)-1-alkanone derivatives and (heterocycle-fused pyrrolidine)-(piperazinyl)-1-alkanone derivatives of formula (I): wherein A, W, R2 and n are as defined in the disclosure, to the method of preparation thereof and the therapeutic use thereof.

公开(公告)号：EP2158194B1

公开(公告)日：2011-05-18

申请号：EP08826271.2

申请日：2008-06-11

申请人： Sanofi-Aventis

发明人： ALAM, Antoine ,  BONO, Françoise ,  DUCLOS, olivier ,  MC CORT, Gary

IPC分类号： C07D401/02 ,  C07D471/04 ,  C07D403/02 ,  A61K31/495 ,  A61P35/00

CPC分类号： C07D471/04

摘要： The invention relates to compounds having formula (I), in which: R
1 and R
2 represent, independently of each other, a hydrogen atom, an alkyl group at C1-C7, optionally substituted by one or more alkoxy groups; R
3 represents an alkyl group at C1-C7; R
4 represents a hydrogen atom, an alkyl group at C1-C4; Y represents an alkoxy group at C1-C4, a group -NRR', -O(CH
2 )
n -C(O)- NRR', wherein R and R' are as defined below and n is an integer equal to 1 or 2; R' represents an alkyl group at C1-C4; and R and R' represent, independently of each other, a hydrogen atom, a -CO-alkyl group at C1-C4 or a -COO' group, wherein R' is as defined above. The invention also relates to the preparation method thereof and to the use of same in therapeutics.

公开(公告)号：EP2158201B1

公开(公告)日：2011-04-13

申请号：EP08826268.8

申请日：2008-06-11

申请人： Sanofi-Aventis

发明人： ALAM, Antoine ,  BISCARRAT, Sandrine ,  BLANC, Isabelle ,  BONO, Françoise ,  DUCLOS, Olivier ,  MC CORT, Gary

IPC分类号： C07D471/04

CPC分类号： C07D213/73 ,  C07D213/82 ,  C07D471/04

摘要： The invention relates to derivatives of 7-alkynyl-1,8-naphthyridones having general formula (I), in which R1, R2, R3 and R4 are as defined in the description. The invention also relates to the preparation method thereof and to the use of same in therapeutics.

摘要翻译： 本发明涉及具有通式（I）的7-炔基-1,8-萘啶酮的衍生物，其中R 1，R 2，R 3和R 4如说明书中所定义。 本发明还涉及其制备方法和其在治疗中的用途。

公开(公告)号：EP1513835B1

公开(公告)日：2006-08-16

申请号：EP03757108.0

申请日：2003-06-05

申请人： Sanofi-Aventis

发明人： BONO, Françoise ,  BOSCH, Michael ,  DOS SANTOS, Victor ,  HERBERT, Jean, Marc ,  NISATO, Dino ,  TONNERRE, Bernard ,  WAGNON, Jean

IPC分类号： C07D417/14 ,  C07D401/14 ,  A61K31/497 ,  A61P25/28

CPC分类号： C07D417/14 ,  C07D401/14

摘要： The invention concerns 1-substituted piperazinylacylpiperidine derivatives of general formula (I), wherein: n is 1 or 2; p is 1 or 2; R1 represents a halogen atom, a trifluoromethyl radical, C1-C4 alkyl, a C1-C4 alkoxy, a trifluoromethoxy radical; R2 represents a hydrogen atom or a halogen atom; R3 represents a hydrogen atom, an -OR5 group, a -CH2OR5 group, a -NR6R7 group; a -NR8COR9 group; a -NR8CONR10R11 group; a -CH2NR12R13 group; a -CH2NR8CONR14R15 group; a C1-C4 alkoxycarbonyl; a -CONR16R17 group; or R3 forms a double bond between the carbon atom whereto it is bound and the neighbouring carbon atom of the piperidine cycle; R4 represents an aromatic group selected among (II), said aromatic groups being unsubstituted, monosubstituted or disubstituted by a substituent selected independently among a halogen atom, a C1-C4 alkyl, a C1-C4 alkoxy, a trifluoromethyl radical. The invention also concerns a method for preparing said compounds and their therapeutic use.

公开(公告)号：EP1513836A1

公开(公告)日：2005-03-16

申请号：EP03757109.8

申请日：2003-06-05

申请人： Sanofi-Aventis

发明人： BONO, Françoise ,  BOSCH, Michael ,  DOS SANTOS, Victor ,  HERBERT, Jean, Marc ,  NISATO, Dino ,  TONNERRE, Bernard ,  WAGNON, Jean

IPC分类号： C07D417/14 ,  C07D401/14 ,  A61K31/497 ,  A61P25/28

CPC分类号： C07D417/14 ,  C07D401/14

摘要： The invention concerns 1-substituted piperazinylacylpiperidine derivatives, of general formula (I), wherein: n is 1 or 2; R1 represents a halogen atom, a trifluoromethyl radical, a C1-C4 alkyl, a C1-C4 alkoxy, a trifluoromethoxy radical; R2 represents a hydrogen atom or a halogen atom; R3 represents a hydrogen atom, an -OR5 group; a -CH2OR5 group; a -NR6R7 group; a -NR8COR9 group; a -NR8CONR10R11 group; a -CH2NR12R13 group; a -CH2NR8CONR14R15 group; a C1-C4 alkoxycarbonyl; a -CONR16R17 group; or R3 forms a double bond between the carbon atom whereto it is bound and the neighbouring carbon atom of the piperidine cycle; R4 represents the aromatic 1,3-thiazol-2-yl group of formula (II). The invention also concerns a method for preparing said compounds and their therapeutic use.