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1.发明授权NOUVEAUX DÉRIVÉS (HÉTÉROCYCLE-TÉTRAHYDRO-PYRIDINE)-(PIPERAZINYL)-1-ALCANONE ET (HÉTÉROCYCLE-DIHYDRO-PYRROLIDINE)-(PIPÉRAZINYL)-1-ALCANONE ET LEUR UTILISATION COMME INHIBITEURS DE P75 有权NEW（杂环/四氢吡啶） - （哌嗪基）-1-AlcañónAND（杂环/ dihydropyrrolidine） - （哌嗪基）-1-Alcañón衍生物及其作为P75抑制剂
公开(公告)号：EP2513088B1
公开(公告)日：2015-07-01
申请号：EP10801663.5
申请日：2010-12-13
申请人： SANOFI
IPC分类号： C07D401/14 , C07D403/14 , C07D407/14 , C07D409/14 , C07D495/04 , A61K31/496 , A61K31/497 , A61K31/4995 , A61K31/506 , A61K31/551 , A61P25/00 , C07D401/04 , C07D407/04 , C07D409/04
CPC分类号： C07D487/08 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D495/04
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2.发明公开NOUVEAUX DERIVES D' (HETEROCYCLE-PIPERIDINE CONDENSEE)-(PIPERAZINYL)-1-ALCANONE OU D' (HETEROCYCLE-PYRROLIDINE CONDENSEE)-(PIPERAZINYL)-1-ALCANONE ET LEUR UTILISATION COMME INHIBITEURS DE p75 有权NEW（杂环/稠合哌啶） - （哌嗪基）-1- ALCANON- OR（杂环/冷凝吡咯烷） - （哌嗪基）-1-Alcañón衍生物及其作为P75抑制剂
公开(公告)号：EP2513108A1
公开(公告)日：2012-10-24
申请号：EP10801662.7
申请日：2010-12-13
申请人： SANOFI
IPC分类号： C07D471/04 , C07D495/04 , C07D513/04 , A61K31/429 , A61K31/381
CPC分类号： C07D487/08 , C07D471/04 , C07D495/04 , C07D513/04
摘要： The disclosure relates to (heterocycle-fused piperidine)-(piperazinyl)-1-alkanone derivatives and (heterocycle-fused pyrrolidine)-(piperazinyl)-1-alkanone derivatives of formula (I): wherein A, W, R2 and n are as defined in the disclosure, to the method of preparation thereof and the therapeutic use thereof.
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3.发明公开ARALKYL-TETRAHYDRO-PYRIDINES, LEUR PREPARATION ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT 有权ARALKYLTETRAHYDROPYRIDINE，生产，药品成分含
公开(公告)号：EP1438291A1
公开(公告)日：2004-07-21
申请号：EP02795311.6
申请日：2002-10-14
申请人： SANOFI-SYNTHELABO
IPC分类号： C07D211/70 , C07D401/04 , A61K31/444 , A61P29/00
CPC分类号： C07D401/04 , C07D211/70
摘要： The invention concerns compounds of formula (I), wherein: X represents N or CH; R1 represents a hydrogen or halogen atom of a CF3 group; n is an integer from 1 to 5; A represents a partly saturated bicyclic or tricyclic carbon compound, as well as their salts or solvates, their N-oxides, pharmaceutical compositions containing them, a method for preparing them and synthesis intermediates in said method.
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4.发明公开PHENYL- ET PYRIDYL-TETRAHYDRO-PYRIDINES POSSEDANT UNE ACTIVITE INHIBITRICE DE FNT 有权苯基和吡啶TETRA HYDRO-吡啶与TNF抑制作用
公开(公告)号：EP1226137A1
公开(公告)日：2002-07-31
申请号：EP00969646.9
申请日：2000-10-19
申请人： SANOFI-SYNTHELABO
IPC分类号： C07D401/06 , A61K31/4709 , A61K31/4725 , A61P9/00 , C07D401/14 , C07D217/02 , C07D215/14
CPC分类号： C07D401/06 , A43B7/125 , A43B9/02 , B29C2045/14844 , B29D35/0045 , B29D35/06 , B29D35/062 , B29D35/122 , B29D35/128 , B29D35/142 , C07D215/14 , C07D217/02 , C07D401/14
摘要： The invention concerns compounds of formula (I) wherein: X represents N or CH; R1 represents a hydrogen or halogen atom, or a CF3 group; R2 and R3 independently represent a hydrogen atom or a methyl group; n is 0 or 1; A represents a group of formula (a) or (b) wherein: R4 represents a hydrogen or halogen atom, a C1-C4 alkyl group, a CF3 group, an amino, mono(C1-C4)alkylamino, di(C1-C4)alkylamino; R5 represents a hydrogen or halogen atom, a (C1-C4)alkoxy group, a (C1-C4)alkyl group or a CF3 group; R6 represents a hydrogen atom, a (C1-C4)alkyl group or a (C1-C4)alkoxy group; and their salts or solvates, pharmaceutical compositions containing them, a method for preparing them and the synthesis intermediates in said method.
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5.发明公开NOVEL THERAPEUTIC USE OF P75 RECEPTOR ANTAGONISTS 审中-公开神经阻滞剂VERWENDUNG VON P75-REZEPTORANTAGONISTEN
公开(公告)号：EP2793889A1
公开(公告)日：2014-10-29
申请号：EP12806060.5
申请日：2012-12-20
申请人： SANOFI
发明人： AVALLONE, Roberta , BARONI, Marco , CROCI, Tiziano
IPC分类号： A61K31/497 , A61K31/498 , A61K31/506 , A61P13/10
CPC分类号： A61K31/4995 , A61K31/46 , A61K31/496 , A61K31/506 , A61K31/55
摘要： The present invention provides for the use of a p75 receptor antagonist or its pharmaceutically acceptable salts for the preparation of a medicament for use in the treatment and/or prevention of overactive bladder.
摘要翻译： 本发明提供了p75受体拮抗剂或其药学上可接受的盐在制备用于治疗和/或预防膀胱过度活动的药物中的用途。
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6.发明公开NOUVEAUX DERIVES (HETEROCYCLE-TETRAHYDRO-PYRIDINE)-(PIPERAZINYL)-1-ALCANONE ET (HETEROCYCLE-DIHYDRO-PYRROLIDINE)-(PIPERAZINYL)-1-ALCANONE ET LEUR UTILISATION COMME INHIBITEURS DE p75 有权NEW（杂环/四氢吡啶） - （哌嗪基）-1-AlcañónAND（杂环/ dihydropyrrolidine） - （哌嗪基）-1-Alcañón衍生物及其作为P75抑制剂
公开(公告)号：EP2513088A1
公开(公告)日：2012-10-24
申请号：EP10801663.5
申请日：2010-12-13
申请人： SANOFI
IPC分类号： C07D401/14 , C07D403/14 , C07D407/14 , C07D409/14 , C07D495/04 , A61K31/496 , A61K31/497 , A61K31/4995 , A61K31/506 , A61K31/551 , A61P25/00 , C07D401/04 , C07D407/04 , C07D409/04
CPC分类号： C07D487/08 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D495/04
摘要： The invention relates to (heterocycle/tetrahydropyridine)-(piperazinyl)-1-alcanone and (heterocycle/dihydropyrrolidine)-(piperazinyl)-1-alcanone derivatives of the general formula (I), where A, W, n, and R2 are as defined in claim 1. The invention moreover relates to the method for preparing said derivatives and to the therapeutic use of said derivatives.
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7.发明授权Dérivés de l'indol-2-one disubstitués en 3, leur préparation et leur application en thérapeutique 有权在位置3二取代的吲哚-2-酮 - 吡啶衍生物，其制备方法及其治疗应用
公开(公告)号：EP2188253B1
公开(公告)日：2012-03-07
申请号：EP08845678.5
申请日：2008-08-14
申请人： SANOFI , Puleo, Letizia
发明人： BARONI, Marco , PULEO, Letizia
IPC分类号： C07D209/40 , C07D401/12 , A61K31/454 , A61K31/496 , A61P3/00 , C07D401/14
CPC分类号： C07D209/40 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14
摘要： The subject of the present invention is indol-2-one derivatives disubstituted in the 3-position, of general formula (I): in which ~, R1, R2, R3, R4, R5, Ar and n are as defined in claim 1, the method for preparing said compounds and the therapeutic use of said compounds.
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8.发明授权NOUVEAUX DERIVES DE (PIPERAZINYL PONTE)-1-ALCANONE ET LEUR UTILISATION COMME INHIBITEURS DE p75 有权作者（桥接哌嗪基）新的衍生-1-Alcañón及其作为P75抑制剂
公开(公告)号：EP2297148B1
公开(公告)日：2012-01-04
申请号：EP09761939.9
申请日：2009-06-12
申请人： SANOFI
IPC分类号： C07D471/08 , C07D487/08 , A61K31/529 , A61P25/00 , A61P29/00 , A61P35/00
CPC分类号： C07D471/08
摘要： The invention relates to derivatives of ((phenyl)-3,6-dihydropyridin-1 yl)- (bridged piperazinyl)-1 -alkanone and ((phenyl)-2,5-dihydro-pyrrol-1 yl)-(bridged piperazinyl)-1 – alkanone derivatives of the general formula (I) where A, B, m, W, n, and R5 are such as defined in Claim 1, to a method for preparing the same, and to the therapeutic application thereof.
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9.发明授权
公开(公告)号：EP1248785B1
公开(公告)日：2005-06-15
申请号：EP00990851.8
申请日：2000-12-29
申请人： Sanofi-Aventis
IPC分类号： C07D409/06 , C07D405/06 , A61K31/4525 , A61K31/4535 , A61P25/28 , A61P25/16 , A61P37/00
CPC分类号： C07D405/06 , C07D409/06
摘要： The invention concerns compounds of formula (I) wherein: R1 represents a hydrogen or halogen atom or a CF3 group; R2 and R3 independently represent a hydrogen atom or a methyl group; n and n' each independently represent 0 or 1;* represents the binding positions; A represents N or CH; X represents a sulphur or oxygen atom; R4 and R5 independently represent a hydrogen atom or a (C1-C6) alkyl group, as well as their salts or solvates. The invention also concerns a method for preparing said compounds and pharmaceutical compositions containing them.
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10.发明公开TETRAHYDROPYRIDYL-ALKYL-HETEROCYCLES, PROCEDE POUR LEUR PREPARATION ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANTS 有权四氢吡啶ALKYL HETEROZYKLE，PROCESS FOR THEIR和药物组合物含幽
公开(公告)号：EP1383762A1
公开(公告)日：2004-01-28
申请号：EP02727676.5
申请日：2002-04-19
申请人： SANOFI-SYNTHELABO
IPC分类号： C07D401/06
CPC分类号： C07D401/06 , C07D401/14
摘要： The invention concerns compounds of formula (I), wherein: X represents N or CH; R1 represents a hydrogen or halogen atom or a CF3 group; R2 and R3 independently represent a hydrogen atom or a methyl group; n is 0 or 1; A represents a nitrogenous heterocycle optionally substituted; and their N-oxides and their salts or solvates, pharmaceutical compositions and medicines containing same and a method for preparing same.
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